30 results on '"Renal oncocytoma"'
Search Results
2. PD11-01 LONG TERM ONCOLOGIC OUTCOMES OF SURGICALLY TREATED RENAL ONCOCYTOMA
- Author
-
Svetlana Avulova, Christine M. Lohse, John C. Cheville, Matvey Tsivian, Vignesh T. Packiam, Stephen A. Boorjian, Bradley C. Leibovich, and R. Houston Thompson
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,medicine ,Long term outcomes ,urologic and male genital diseases ,business ,Renal oncocytoma ,medicine.disease ,Surgery ,Term (time) - Abstract
INTRODUCTION AND OBJECTIVE:The available data on long term outcomes of surgically treated renal oncocytoma (RO) are scant and largely outdated. Herein we describe our institutional outcomes of surg...
- Published
- 2020
3. MP19-01 USE OF AUTOMATION AND COMPUTER VISION IN DIFFERENTIATING BENIGN RENAL ONCOCYTOMA FROM CHROMOPHOBE RENAL CELL CARCINOMA: PROOF OF CONCEPT
- Author
-
Naif A. Aldhaam, Ahmed A. Hussein, Lora Cavuoto, Khurshid A. Guru, Ahmed Elsayed, Eric Kauffman, and Amir Baghdadi
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,Chromophobe Renal Cell Carcinoma ,medicine ,Radiology ,urologic and male genital diseases ,medicine.disease ,Renal oncocytoma ,business ,Kidney cancer - Abstract
INTRODUCTION AND OBJECTIVES:Among the >65,000 new kidney cancer cases in the U.S., about 10% of these patients turn out to have benign renal cell oncocytomas (Onco). They face a 30% risk of complic...
- Published
- 2019
4. MP48-20 CONTEMPORARY SURGICAL MANAGEMENT OF RENAL ONCOCYTOMA: A NATION’S OUTCOME
- Author
-
Maxine Gb Tran, Timothy O'Brien, Ravi Barod, Michael Aitchison, John Withington, Axel Bex, Faiz Mumtaz, Sarah Fowler, Prasad Patki, and Joana B. Neves
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,General surgery ,medicine ,business ,Renal oncocytoma ,medicine.disease ,Outcome (game theory) - Published
- 2018
5. Coexisting Hybrid Malignancy in a Solitary Sporadic Solid Benign Renal Mass: Implications for Treating Patients Following Renal Biopsy
- Author
-
Reza Mehrazin, Elizabeth R. Plimack, Robert G. Uzzo, Essel Dulaimi, Alexander Kutikov, Tahseen Al-Saleem, David Y.T. Chen, John Walton, Anthony Corcoran, Jeffrey J. Tomaszewski, Marc C. Smaldone, Richard E. Greenberg, Serge Ginzburg, and Rosalia Viterbo
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Angiomyolipoma ,Adenoma ,Urology ,urologic and male genital diseases ,Malignancy ,Renal cell carcinoma ,medicine ,Adenoma, Oxyphilic ,Humans ,Oncocytoma ,Renal oncocytoma ,Aged ,Retrospective Studies ,Kidney ,medicine.diagnostic_test ,business.industry ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Kidney Neoplasms ,medicine.anatomical_structure ,Female ,Renal biopsy ,business - Abstract
Concern regarding coexisting malignant pathology in benign renal tumors deters renal biopsy and questions its validity. We examined the rates of coexisting malignant and high grade pathology in resected benign solid solitary renal tumors.Using our prospectively maintained database we identified 1,829 patients with a solitary solid renal tumor who underwent surgical resection between 1994 and 2012. Lesions containing elements of renal oncocytoma, angiomyolipoma or another benign pathology formed the basis for this analysis. Patients with an oncocytic malignancy without classic oncocytoma and those with known hereditary syndromes were excluded from study.We identified 147 patients with pathologically proven elements of renal oncocytoma (96), angiomyolipoma (44) or another solid benign pathology (7). Median tumor size was 3.0 cm (IQR 2.2-4.5). As quantified by the R.E.N.A.L. (radius, exophytic/endophytic, nearness to collecting system or sinus, anterior/posterior and location relative to polar lines) nephrometry score, tumor anatomical complexity was low in 28% of cases, moderate in 56% and high in 16%. Only 4 patients (2.7%) were documented as having hybrid malignant pathology, all involving chromophobe renal cell carcinoma in the setting of renal oncocytoma. At a median followup of 44 months (IQR 33-55) no patient with a hybrid tumor experienced regional or metastatic progression.In our cohort of patients with a solitary, sporadic, solid benign renal mass fewer than 3% of tumors showed coexisting hybrid malignancy. Importantly, no patient harbored coexisting high grade pathology. These data suggest that uncertainty regarding hybrid malignant pathology coexisting with benign pathological components should not deter renal biopsy, especially in the elderly and comorbid populations.
- Published
- 2014
6. Re: The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis
- Author
-
Anthony Atala
- Subjects
business.industry ,Urology ,030232 urology & nephrology ,Genomics ,medicine.disease_cause ,Bioinformatics ,medicine.disease ,Kidney Neoplasms ,Article ,Diagnosis, Differential ,03 medical and health sciences ,Cell Transformation, Neoplastic ,0302 clinical medicine ,medicine ,Adenoma, Oxyphilic ,Humans ,Differential diagnosis ,Carcinogenesis ,business ,Renal oncocytoma ,Carcinoma, Renal Cell - Abstract
SUMMARY Oncocytomas are predominantly benign neoplasms possessing pathogenic mitochondrial mutations and accumulation of respiration-defective mitochondria, characteristics of unknown significance. Using exome and transcriptome sequencing, we identified two main subtypes of renal oncocytoma. Type 1 is diploid with CCND1 rearrangements, whereas type 2 is aneuploid with recurrent loss of chromosome 1, X or Y, and/or 14 and 21, which may proceed to more aggressive eosinophilic chromophobe renal cell carcinoma (ChRCC). Oncocytomas activate 5′ adenosine monophosphate-activated protein kinase (AMPK) and Tp53 (p53) and display disruption of Golgi and autophagy/lysosome trafficking, events attributed to defective mitochondrial function. This suggests that the genetic defects in mitochondria activate a metabolic checkpoint, producing autophagy impairment and mitochondrial accumulation that limit tumor progression, revealing a novel tumor-suppressive mechanism for mitochondrial inhibition with metformin. Alleviation of this metabolic checkpoint in type 2 by p53 mutations may allow progression to eosinophilic ChRCC, indicating that they represent higher risk., Graphical abstract
- Published
- 2017
7. HISTOPATHOLOGY AND MOLECULAR GENETICS OF RENAL TUMORS: TOWARD UNIFICATION OF A CLASSIFICATION SYSTEM
- Author
-
W. Marston Linehan, McClellan M. Walther, Norman Zambrano, Irina A. Lubensky, and Maria J. Merino
- Subjects
medicine.medical_specialty ,Pathology ,business.industry ,Urology ,Papillary Adenoma ,urologic and male genital diseases ,medicine.disease ,Basophilic ,Molecular genetics ,Carcinoma ,Medicine ,Histopathology ,business ,Renal oncocytoma ,Clear cell ,Kidney disease - Abstract
Purpose: We characterize the genetic abnormalities associated with pathological subtypes of renal tumors, which may help diagnosis or prognostication.Materials and Methods: A comprehensive literature review of genetic abnormalities associated with different renal tumor subtypes was performed.Results: Studies of sporadic and hereditary forms suggest that abnormalities in the von Hippel-Lindau and met genes are the earliest changes in conventional (clear cell) and papillary basophilic renal cancers, respectively. Renal oncocytoma and chromophobe carcinoma have common genetic abnormalities, suggesting a relationship. A similar finding has been observed between papillary adenoma and papillary basophilic renal cancer.Conclusions: These findings suggest that molecular diagnostic testing will help determine histopathological diagnosis, identify tumor types with similar genetic abnormalities suggesting a common origin and indicate potential prognostic markers for future study.
- Published
- 1999
8. 1312 CHANGES IN RENAL FUNCTION AFTER RENAL SURGERY AND THE ANALYSIS OF FACTORS AFFECTING THE DEVELOPMENT OF CHRONIC RENAL INSUFFICIENCY; MULTICENTER STUDY
- Author
-
Yong Sun Choi, Sung-Hoo Hong, Hyo Sin Kim, Seok Ho Kang, Yong Hyun Park, Yong-June Kim, and Seok-Soo Byun
- Subjects
medicine.medical_specialty ,Surgical margin ,business.industry ,Urology ,medicine.medical_treatment ,Renal function ,Chromophobe cell ,urologic and male genital diseases ,medicine.disease ,Nephrectomy ,medicine ,Oncocytoma ,Stage (cooking) ,Renal oncocytoma ,business ,Clear cell - Abstract
of the PC away from normal renal parenchyma) is classically used for familial Renal Cell Carcinoma (RCC) but has not been widely adopted for sporadic RCC. We investigate whether tumor histology predicts the presence, thickness, and extension of tumor through the PC, potentially identifying tumors best suited for a TE nephron-sparing approach. METHODS: Twenty-five consecutive total or partial nephrectomies for pT1 clear cell, papillary, chromophobe, and oncocytoma were included (N 100 total tumors). Specimens were reviewed for numerous pathological features including stage, grade, lympho-vascular invasion, as well as characteristics of PC such as capsular presence/ absence, mean thickness, continuity, and tumor capsule invasion (TCI). PC parameters (thinnest, thickest and mean) were calculated from multiple measurements using an ocular micrometer, rounded to the nearest tenth of a millimeter. RESULTS: Tumor sizes in each group were similar. PC was complete in: papillary (n 21, 84%), clear cell (n 19, 76%), chromophobe (n 7, 28%), and oncocytoma (n 1, 4%); present but incomplete in oncocytoma (n 14, 56%), chromophobe (n 11, 44%), clear cell (n 6, 24%), and papillary (n 2, 8%); and absent in oncocytoma (n 10, 40%), chromophobe (n 7, 28%), papillary(n 2, 8%), and clear cell (0%). TCI was seen in 30% of papillary and only 8% of clear cell (p-value 0.006) PC. When present, mean thickness of the PC was significantly thicker for clear cell (0.8mm) when compared to the other tumors (papillary and chromophobe 0.6mm and oncocytoma 0.3mm). Multivariate logistic regression demonstrated only tumor type to be significantly associated with TCI (p-value 0.046, OR 10.3 (95%CI)). CONCLUSIONS: In pT1 renal tumors, PC appears predictable based on tumor histology. The PC is likely to be absent or incomplete in renal oncocytoma and chromophobe. Papillary RCC demonstrates the highest % of TCI which could predict higher surgical margin rates during TE surgery. Clear cell RCC possesses the thickest, most complete tumor capsule with minimal TCI and may be best suited for TE partial nephrectomy.
- Published
- 2013
9. Fluorescence In Situ Hybridization Analysis of Renal Oncocytoma Reveals Frequent Loss of Chromosomes Y and 1
- Author
-
Michael M. Lieber, Diane L. Persons, David G. Bostwick, Junqi Qian, Thomas J. Borell, Antonio Alcaraz, James A. Brown, Satoru Takahashi, Kari L. Anderl, and Robert B. Jenkins
- Subjects
Pathology ,medicine.medical_specialty ,Kidney ,medicine.diagnostic_test ,Urology ,Chromosome ,Biology ,medicine.disease ,Y chromosome ,medicine.anatomical_structure ,medicine ,Oncocytoma ,Renal oncocytoma ,X chromosome ,Chromosome 12 ,Fluorescence in situ hybridization - Abstract
Purpose: Cytogenetic studies of a small number of renal oncocytomas have indicated that loss of chromosomes 1 and Y may be involved in the pathogenesis of this tumor. To evaluate these observations further we selected paraffin embedded renal oncocytoma specimens from 20 male and 10 female patients for fluorescence in situ hybridization analysis.Materials and Methods: Isolated nuclei were prepared from paraffin embedded specimens, and fluorescence in situ hybridization was performed with enumeration probes for chromosomes 1, 12, × and Y.Results: Tumors from 10 male (50 percent) and 4 female (40 percent) patients demonstrated chromosomal alterations. Loss of chromosome Y was observed in specimens from all 10 male patients, and loss of chromosome 1 or gain of chromosome 12 was noted in 5 and 2 of these specimens, respectively. Of the 4 female patients with chromosomal abnormalities 2 had loss of chromosome 1, 1 had gain of chromosome 1 and 1 had gain of chromosome 12.Conclusions: Our results confirm ...
- Published
- 1996
10. Nuclear Morphometry in Differential Diagnosis of Renal Oncocytoma and Renal Cell Carcinoma
- Author
-
Yrjö Collan, J. P. T. Castren, Martti Nurmi, and Teijo Kuopio
- Subjects
Pathology ,medicine.medical_specialty ,Kidney ,business.industry ,Urology ,Histology ,urologic and male genital diseases ,Stage t1 ,medicine.disease ,Nuclear shape ,medicine.anatomical_structure ,Renal cell carcinoma ,Medicine ,Oncocytoma ,Differential diagnosis ,business ,Renal oncocytoma - Abstract
Purpose: Morphometric distinction of renal oncocytoma and renal cell carcinoma was attempted.Materials and Methods: Nuclear morphometric measurements were done from sections of 16 histologically diagnosed renal oncocytomas and renal cell carcinoma controls (grade 1 or 2, stage T1 to 2N0M0).Results: Oncocytomas could be distinguished from carcinomas on the basis of nuclear morphometry in more than 80 percent of the cases. Especially, the shape descriptors (form factors) were significantly different between oncocytomas and carcinomas.Conclusions: Morphometrically determined nuclear shape descriptors can be used to support diagnostic decisions in problematic cases.
- Published
- 1995
11. Renal Oncocytoma: Clinical and Biological Correlates
- Author
-
Raymond R. Tubbs, Eric A. Klein, Andrew C. Novick, Stevan B. Streem, Howard S. Levin, and Mark R. Licht
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Urology ,urologic and male genital diseases ,Diagnosis, Differential ,Neoplasms, Multiple Primary ,Antigen ,HLA Antigens ,Renal cell carcinoma ,Carcinoma ,medicine ,Adenoma, Oxyphilic ,Humans ,Oncocytoma ,Renal oncocytoma ,Carcinoma, Renal Cell ,Aged ,Aged, 80 and over ,Kidney ,Ploidies ,Epithelioma ,business.industry ,Incidence ,DNA, Neoplasm ,Middle Aged ,medicine.disease ,Kidney Neoplasms ,medicine.anatomical_structure ,Immunohistochemistry ,Female ,business ,Follow-Up Studies - Abstract
We treated 31 patients with renal oncocytoma. Renal cell carcinoma was found existing separately within the same or contralateral kidney in 10 patients (32%). Followup of 29 patients revealed 24 alive with no evidence of disease and 1 alive with recurrent oncocytoma, while 1 with coexistent tumors died of progressive renal cell carcinoma and 3 tumor-free patients died of unrelated diseases. Quantitative deoxyribonucleic acid analysis was performed on cell suspensions of fresh tumor by flow cytometry or by image cytometry on touch preparations from frozen tissue in 16 patients with renal oncocytoma. Ploidy analysis revealed all oncocytomas to be diploid. Frozen tissue immunohistology was performed using murine monoclonal antibody against human HLA-A, B and C (class I) antigens with the avidin-biotin peroxidase technique in 11 patients with renal oncocytoma. Ten oncocytomas did not express these self-recognition antigens and 1 was only weakly positive for antigen expression. In contrast, renal cell carcinomas strongly expressed HLA class I antigens. The high incidence of coexistence of renal oncocytoma and renal cell carcinoma has important clinical implications. Loss of HLA class I antigen expression by renal oncocytomas may provide an additional method for differentiating this lesion from renal cell carcinoma.
- Published
- 1993
12. RENAL ONCOCYTOMA: MULTIFOCALITY, BILATERALISM, METACHRONOUS TUMOR DEVELOPMENT AND COEXISTENT RENAL CELL CARCINOMA
- Author
-
Christopher Dechet, David G. Bostwick, Horst Zincke, Michael L. Blute, and Sandra C. Bryant
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adenoma ,Urology ,medicine.medical_treatment ,urologic and male genital diseases ,Neoplasms, Multiple Primary ,Renal cell carcinoma ,medicine ,Carcinoma ,Adenoma, Oxyphilic ,Humans ,Oncocytoma ,Renal oncocytoma ,Carcinoma, Renal Cell ,Aged ,Aged, 80 and over ,Kidney ,business.industry ,Incidence ,Middle Aged ,medicine.disease ,Kidney Neoplasms ,Nephrectomy ,Surgery ,medicine.anatomical_structure ,Female ,Radiology ,business ,Kidney disease - Abstract
We analyzed a large series of cases of renal oncocytoma to define the incidence of coexistent renal cell carcinoma, multifocality, bilateralism and metachronous tumor development.Between 1980 and 1997, 100 men and 38 women with a mean age of 68 years with oncocytoma, were treated surgically at our institution. We analyzed tumor characteristics and reviewed specimens for coexistent renal cell carcinoma.Tumors were discovered incidentally in 58% of the cases. Specimens were obtained from 84 radical and 70 partial nephrectomies. Tumor size ranged from 0.3 to 14.5 cm. (median 3.2). Oncocytoma was unilateral in 131 cases (95%) and bilateral in 7 (5%), while there were multiple oncocytomas in 8 (6%). Mean followup was 41 months (range 0 to 200). The disease specific survival rate was 100% and no patient had metastasis. In 6 patients (4%) metachronous oncocytoma developed during followup. No patient had locally recurrent oncocytoma after partial nephrectomy for a solitary renal oncocytoma. Renal cell carcinoma and oncocytoma were found in 14 patients (10%), including unilateral synchronous disease in 9 and bilateral synchronous disease in 5.Our data support the benign nature of renal oncocytoma. Multifocality, bilateralism and metachronous tumor develop in approximately 4 to 6% of all cases. Renal cell carcinoma coexisted in 10% of oncocytoma cases.
- Published
- 1999
13. Re: MRI Features of Renal Oncocytoma and Chromophobe Renal Cell Carcinoma
- Author
-
Samir S. Taneja
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Urology ,Chromophobe Renal Cell Carcinoma ,medicine ,Renal oncocytoma ,medicine.disease ,business - Published
- 2011
14. Molecular Analysis of the Short Arm of Chromosome 3 in Five Renal Oncocytomas
- Author
-
Hiltrud Brauch, Mark A. Lovell, D.J. Weaver, W. M. Linehan, K. Tory, and Berton Zbar
- Subjects
Adenoma ,Male ,Heterozygote ,Pathology ,medicine.medical_specialty ,Urology ,Renal neoplasia ,Biology ,urologic and male genital diseases ,Renal cell carcinoma ,medicine ,Humans ,Oncocytoma ,Allele ,Renal oncocytoma ,Alleles ,Aged ,Kidney ,DNA, Neoplasm ,Middle Aged ,medicine.disease ,Kidney Neoplasms ,Molecular analysis ,medicine.anatomical_structure ,Chromosome 3 ,Chromosomes, Human, Pair 3 ,DNA Probes - Abstract
Renal oncocytomas were tested for loss of alleles at loci on the short arm of chromosome 3, a genetic change characteristic of human renal cell carcinoma. Five renal oncocytomas did not show loss of alleles at loci on 3p supporting the view that renal oncocytoma is a distinct form of renal neoplasia.
- Published
- 1990
15. Renal Oncocytoma with a Translocation t(9;11)(p23;q13)
- Author
-
Bastian Gunawan, László Füzesi, Stefan Braun, and Wieland Boeckmann
- Subjects
Adult ,congenital, hereditary, and neonatal diseases and abnormalities ,Pathology ,medicine.medical_specialty ,Urology ,Chromosome 9 ,Chromosomal translocation ,Biology ,urologic and male genital diseases ,Translocation, Genetic ,medicine ,Adenoma, Oxyphilic ,Humans ,Oncocytoma ,Renal oncocytoma ,Kidney ,Chromosomes, Human, Pair 11 ,Chromosome ,Karyotype ,medicine.disease ,Molecular biology ,Kidney Neoplasms ,medicine.anatomical_structure ,Karyotyping ,Female ,Chromosome 20 ,Chromosomes, Human, Pair 9 - Abstract
We report a case of renal oncocytoma and confirm a tumor type specific translocation between chromosomes 9 and 11, that is t(9;11)(p23;q13q23). Each of the 45 cytogenetically analyzed metaphases of tumor cells showed a translocation of the long arm of chromosome 11 at q13 to chromosome 9 at 9p23 and to chromosome 20 at 20q13 that resulted in the following karyotype: 6,XX,der(11)ins(9;11)(p23;q13q23)ins(20;11)(q13;q23q25),del(22q13). Since genes encoding mitochondrial enzymes are clustered around the translocation site of chromosomes 11 and 20, they may have a role in the tumorigenesis of renal oncocytoma. In addition, if the development of oncocytomas shows different cytogenetic pathways the cytogenetic aberration of t(9;11)(p23; q12q13) can be of diagnostic help in differentiating a subset of oncocytoma from renal cell carcinoma.
- Published
- 1994
16. Renal Oncocytoma Arising from a Renal Cyst: A Case Report and Review of the Literature
- Author
-
Nehemia Hampel, Andrew A. Selzman, and Medhat O. Hassan
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Kidney ,Unusual case ,Adenoma ,business.industry ,Urology ,Kidney Diseases, Cystic ,urologic and male genital diseases ,medicine.disease ,Kidney Neoplasms ,Simple renal cyst ,medicine.anatomical_structure ,Adenoma, Oxyphilic ,Humans ,Medicine ,Histopathology ,Cyst ,Oncocytoma ,business ,Renal oncocytoma ,Aged - Abstract
Renal oncocytoma accounts for approximately 3 to 4% of all solid renocortical tumors. An unusual case of renal oncocytoma arising from the wall of a simple renal cyst is reported and the literature is reviewed.
- Published
- 1994
17. Coexisting hybrid malignancy in a solitary sporadic solid benign renal mass: implications for treating patients following renal biopsy.
- Author
-
Ginzburg S, Uzzo R, Al-Saleem T, Dulaimi E, Walton J, Corcoran A, Plimack E, Mehrazin R, Tomaszewski J, Viterbo R, Chen DY, Greenberg R, Smaldone M, and Kutikov A
- Subjects
- Adenoma, Oxyphilic metabolism, Adenoma, Oxyphilic surgery, Aged, Angiomyolipoma metabolism, Angiomyolipoma surgery, Female, Humans, Immunohistochemistry, Kidney Neoplasms metabolism, Male, Middle Aged, Retrospective Studies, Adenoma, Oxyphilic pathology, Angiomyolipoma pathology, Kidney Neoplasms pathology, Kidney Neoplasms surgery
- Abstract
Purpose: Concern regarding coexisting malignant pathology in benign renal tumors deters renal biopsy and questions its validity. We examined the rates of coexisting malignant and high grade pathology in resected benign solid solitary renal tumors., Materials and Methods: Using our prospectively maintained database we identified 1,829 patients with a solitary solid renal tumor who underwent surgical resection between 1994 and 2012. Lesions containing elements of renal oncocytoma, angiomyolipoma or another benign pathology formed the basis for this analysis. Patients with an oncocytic malignancy without classic oncocytoma and those with known hereditary syndromes were excluded from study., Results: We identified 147 patients with pathologically proven elements of renal oncocytoma (96), angiomyolipoma (44) or another solid benign pathology (7). Median tumor size was 3.0 cm (IQR 2.2-4.5). As quantified by the R.E.N.A.L. (radius, exophytic/endophytic, nearness to collecting system or sinus, anterior/posterior and location relative to polar lines) nephrometry score, tumor anatomical complexity was low in 28% of cases, moderate in 56% and high in 16%. Only 4 patients (2.7%) were documented as having hybrid malignant pathology, all involving chromophobe renal cell carcinoma in the setting of renal oncocytoma. At a median followup of 44 months (IQR 33-55) no patient with a hybrid tumor experienced regional or metastatic progression., Conclusions: In our cohort of patients with a solitary, sporadic, solid benign renal mass fewer than 3% of tumors showed coexisting hybrid malignancy. Importantly, no patient harbored coexisting high grade pathology. These data suggest that uncertainty regarding hybrid malignant pathology coexisting with benign pathological components should not deter renal biopsy, especially in the elderly and comorbid populations., (Copyright © 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
18. Renal Oncocytoma with Synchronous Contralateral Renal Cell Carcinoma
- Author
-
William J. Catalona, R. J. Torrence, and Louis R. Kavoussi
- Subjects
Adenoma ,Male ,medicine.medical_specialty ,business.industry ,Urology ,Kidney pathology ,Kidney ,urologic and male genital diseases ,medicine.disease ,Kidney Neoplasms ,Neoplasms, Multiple Primary ,Renal cell carcinoma ,Carcinoma ,medicine ,Humans ,Oncocytoma ,Renal oncocytoma ,business ,Carcinoma, Renal Cell ,Aged - Abstract
We report a case of simultaneous contralateral oncocytoma and renal cell carcinoma. The diagnosis and prognosis of renal oncocytoma are discussed, and the management of bilateral renal tumors is reviewed.
- Published
- 1985
19. Flow Cytometry of Renal Oncocytoma: Common Occurrence of Deoxyribonucleic Acid Polyploidy and Aneuploidy
- Author
-
George M. Farrow, Michael M. Lieber, and Leslie M. Rainwater
- Subjects
Adenoma ,Pathology ,medicine.medical_specialty ,Urology ,Population ,Aneuploidy ,Biology ,Polyploidy ,chemistry.chemical_compound ,Polyploid ,medicine ,Humans ,Oncocytoma ,Propidium iodide ,Renal oncocytoma ,education ,Cell Nucleus ,education.field_of_study ,Staining and Labeling ,DNA, Neoplasm ,Flow Cytometry ,medicine.disease ,Kidney Neoplasms ,chemistry ,Cytometry ,DNA - Abstract
Flow cytometry was performed on 51 typical specimens of renal oncocytoma. Nuclei were extracted from paraffin-embedded archival material and isolated nuclei were stained with propidium iodide. Of the 51 available tissue blocks 86 per cent were evaluable and 50 per cent of these samples showed a deoxyribonucleic acid (DNA) histogram that was approximately the same as normal renal parenchyma. Of the oncocytoma samples 39 per cent showed a marked increase (more than 10 per cent of the nuclei) in the tetraploid DNA peak, while 11 per cent showed a distinct DNA aneuploid peak. Among 21 evaluable grade 2 oncocytic renal tumors 33 per cent showed a normal DNA histogram, 43 per cent showed a marked increase in the DNA tetraploid peak and 24 per cent showed a DNA aneuploid peak. The common presence of polyploid nuclei containing double quantities of chromosomal DNA may correlate with the long-standing pathological observation that oncocytic tumors often contain a distinct population of large nuclei. Indeed, 86 per cent concurrence was seen between the detection of an abnormal DNA content by flow cytometry and the histopathological presence of large abnormal nuclei in these specimens. Since renal oncocytomas (grade 1 oncocytic tumors) rarely, if ever, metastasize and are relatively noninvasive locally, their markedly abnormal flow cytometry patterns are of considerable interest. Moreover, DNA polyploidy has not been identified previously in renal tumors. The biological significance and mechanism of DNA polyploidy, and the relationship of DNA polyploidy and DNA aneuploidy to the pathogenesis of oncocytic renal tumors require further laboratory investigation. The clinical use of flow cytometry to classify and to predict the behavior of renal tumors will be complicated, since renal oncocytomas commonly have polyploid and aneuploid DNA histograms.
- Published
- 1986
20. Bilateral Renal Oncocytoma: Report of 2 Cases and Review of Literature
- Author
-
Ronald W. Raspa, Joseph N. Ward, and Manuel Fernandes
- Subjects
Adenoma ,Male ,medicine.medical_specialty ,Conservative management ,business.industry ,Urology ,medicine.medical_treatment ,Disease ,Middle Aged ,urologic and male genital diseases ,medicine.disease ,Nephrectomy ,Kidney Neoplasms ,Surgery ,Radiography ,Radiological weapon ,Humans ,Medicine ,Female ,Radiology ,business ,Renal oncocytoma ,Pathological ,Aged - Abstract
We report 2 cases of synchronous bilateral renal oncocytoma treated by radical nephrectomy on 1 side and by partial nephrectomy on the other side. Long-term followup serves to confirm the noninvasive nature of this disease. We recommend conservative management based upon radiological and gross pathological findings.
- Published
- 1985
21. Renal Oncocytoma: A Diagnostic and Therapeutic Dilemma
- Author
-
Thomas J. Maatman, Benjamin F. Tancinco, James E. Montie, Andrew C. Novick, Howard S. Levin, Drogo K. Montague, and Zissis Vesoulis
- Subjects
Adenoma ,Adult ,Male ,medicine.medical_specialty ,Urology ,Radiography ,medicine.medical_treatment ,Kidney ,urologic and male genital diseases ,Nephrectomy ,Diagnosis, Differential ,Renal cell carcinoma ,Pathognomonic ,medicine ,Humans ,Renal oncocytoma ,Carcinoma, Renal Cell ,Pathological ,Aged ,Retrospective review ,business.industry ,Middle Aged ,medicine.disease ,Kidney Neoplasms ,Female ,Radiology ,Differential diagnosis ,business - Abstract
From 1968 to 1983, 254 patients underwent an operation for presumed renal cell carcinoma. In this retrospective review the pathological diagnosis was renal oncocytoma in 11 patients (4 per cent). Renal oncocytomas were present bilaterally in 2 patients, including 1 with a coexisting renal cell carcinoma. In 2 other patients the oncocytomas were multicentric. The angiographic, computerized tomographic and sonographic findings in these patients typified renal cell carcinoma. Surgical treatment comprised radical or partial nephrectomy for unilateral and bilateral lesions, respectively. Because of the benign nature, multicentricity, possible bilaterality and absence of pathognomonic radiographic features, renal oncocytomas should be considered in the differential diagnosis of solid renal masses.
- Published
- 1984
22. Chromosome Anomalies Suggestive of Malignant Transformation in Bilateral Renal Oncocytoma
- Author
-
George R. Prout, Kostantinos E. Psihramis, Mitsuaki A. Yoshida, Avery A. Sandberg, and Alex F. Althausen
- Subjects
Adenoma ,Monosomy ,Pathology ,medicine.medical_specialty ,X Chromosome ,Urology ,Trisomy ,Kidney ,urologic and male genital diseases ,Malignant transformation ,Neoplasms, Multiple Primary ,medicine ,Humans ,Oncocytoma ,Renal oncocytoma ,X chromosome ,Aged ,Chromosome Aberrations ,Chromosomes, Human, Pair 14 ,Chromosome 7 (human) ,Genetics ,business.industry ,Chromosome ,medicine.disease ,Kidney Neoplasms ,Cell Transformation, Neoplastic ,Female ,Chromosomes, Human, Pair 3 ,business ,Chromosomes, Human, Pair 7 - Abstract
A patient with bilateral renal oncocytoma is presented, and the clinical, radiological and pathological characteristics of this uncommon, clinically benign renal tumor are discussed briefly. Chromosomal analysis studies revealed the following clonal abnormalities: trisomy of chromosome 7, and monosomy of chromosomes 3 and 14, and the X chromosome. A possible clonal abnormality of chromosome 10 and 3 nonclonal anomalies also were identified. The same anomalies were present in both tumors. These karyotypic anomalies are compatible with malignant transformation of the cells of these tumors and, since benign tumors rarely are associated with demonstrable cytogenetic changes, they suggest that oncocytoma, although clinically benign, may have malignant potential.
- Published
- 1986
23. A Case of Bilateral Renal Oncocytoma
- Author
-
Masaru Tomita, Yuh Fukuda, Kazuhiro Yoshida, Hara M, Hiroshi Kawai, and Masao Akimoto
- Subjects
Adenoma ,medicine.medical_specialty ,business.industry ,Biopsy ,Urology ,Urography ,Adenocarcinoma ,Middle Aged ,Kidney ,urologic and male genital diseases ,medicine.disease ,Kidney Neoplasms ,Diagnosis, Differential ,Neoplasms, Multiple Primary ,Microscopy, Electron ,medicine ,Humans ,Female ,Radiology ,Tomography, X-Ray Computed ,Renal oncocytoma ,business - Abstract
To our knowledge, we report the first case of bilateral renal oncocytoma. Among more than 100 such cases reported recently no bilateral tumors could be found.
- Published
- 1982
24. Renal Oncocytoma: Report of a Case With Unusual Presentation
- Author
-
Antonio G. Nascimento and Antonio Carlos F. Moura
- Subjects
Adenoma ,Adult ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Biopsy ,Urology ,Adenocarcinoma ,Kidney ,urologic and male genital diseases ,medicine.disease ,Kidney Neoplasms ,Diagnosis, Differential ,Neoplasms, Multiple Primary ,Humans ,Medicine ,Neoplasm ,Female ,Radiology ,Presentation (obstetrics) ,business ,Renal oncocytoma ,Surgical treatment ,Left kidney - Abstract
We report a case of bilateral renal oncocytoma, which was diagnosed by biopsy of the left kidney tumor. The patient refused surgical treatment. After a 6-year followup she is well, which proves the benign behavior of this neoplasm. The clinical, morphologic and angiographic characteristics of the tumor are discussed.
- Published
- 1982
25. Renal Oncocytoma: A Protocol for Diagnostic Evaluation
- Author
-
P.T. Nieh and P. D’Addario
- Subjects
Protocol (science) ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,Radiology ,Diagnostic evaluation ,Renal oncocytoma ,medicine.disease ,business - Published
- 1987
26. Immunologic Analysis of Renal Oncocytoma
- Author
-
K. Scott Coffield, John Kochevar, James A. Reynolds, and Richard C. Klugo
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,Renal oncocytoma ,medicine.disease ,business - Published
- 1987
27. Preoperative Diagnosis of Renal Oncocytoma: A New Approach
- Author
-
Ruben F. Gittes and Larry A. Levine
- Subjects
medicine.medical_specialty ,business.industry ,Urology ,Medicine ,Radiology ,business ,Renal oncocytoma ,medicine.disease - Published
- 1987
28. Multifocal Renal Oncocytoma
- Author
-
Karl T.K. Chen
- Subjects
Adenoma ,Pathology ,medicine.medical_specialty ,Kidney ,business.industry ,Urology ,urologic and male genital diseases ,medicine.disease ,Kidney Neoplasms ,Resection ,Neoplasms, Multiple Primary ,medicine.anatomical_structure ,medicine ,Humans ,Female ,Oncocytoma ,business ,Renal oncocytoma ,Aged - Abstract
A case of multifocal oncocytoma of the kidney is reported. A review of the literature revealed only 2 other cases with multifocal tumors. The occurrence of these multicentric tumors should discourage the attempt of performing partial renal resection as recently advocated by some authors.
- Published
- 1983
29. Vasculitis Associated With Renal Oncocytoma
- Author
-
F.C. Levin, B.R. Susman, F. Fromowitz, and P. Barland
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Urology ,MEDLINE ,Medicine ,business ,Renal oncocytoma ,medicine.disease ,Vasculitis - Published
- 1982
30. Renal Oncocytoma: A Report of Two Cases With Immunohistochemical Evaluation
- Author
-
J.H.J.M. van Krieken, A. A. B. Lycklama à Nijeholt, D. J. Ruiter, and Egbert Oosterwijk
- Subjects
Adenoma ,Male ,Pathology ,medicine.medical_specialty ,Urology ,Kidney ,urologic and male genital diseases ,Distal nephron ,Pathology and Forensic Medicine ,Neoplasms, Multiple Primary ,Immunophenotyping ,Renal cell carcinoma ,medicine ,Humans ,Oncocytoma ,Renal oncocytoma ,Carcinoma, Renal Cell ,Electron microscopic ,Aged ,business.industry ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Kidney Neoplasms ,Microscopy, Electron ,medicine.anatomical_structure ,business - Abstract
Two cases of renal oncocytoma are characterized by histologic electron microscopic, and immunohistochemical evaluation. In one case there was a coexistent renal cell carcinoma. The immunophenotype of the oncocytes provide evidence for an origin from the distal nephron. The results indicate that immunohistochemical methods can be helpful in discriminating renal oncocytoma from (granular type) renal cell carcinoma.
- Published
- 1989
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.