Nuclear Morphometry in Differential Diagnosis of Renal Oncocytoma and Renal Cell Carcinoma

Purpose: Morphometric distinction of renal oncocytoma and renal cell carcinoma was attempted.Materials and Methods: Nuclear morphometric measurements were done from sections of 16 histologically diagnosed renal oncocytomas and renal cell carcinoma controls (grade 1 or 2, stage T1 to 2N0M0).Results: Oncocytomas could be distinguished from carcinomas on the basis of nuclear morphometry in more than 80 percent of the cases. Especially, the shape descriptors (form factors) were significantly different between oncocytomas and carcinomas.Conclusions: Morphometrically determined nuclear shape descriptors can be used to support diagnostic decisions in problematic cases.