1. Tissue Sodium in Patients With Early Stage Hypertension: A Randomized Controlled Trial
- Author
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Aseel Alsouqi, Serpil Muge Deger, Melis Sahinoz, Cindy Mambungu, Adrienne R. Clagett, Aihua Bian, Andrew Guide, Thomas G. Stewart, Mindy Pike, Cassianne Robinson‐Cohen, Rachelle Crescenzi, Meena S. Madhur, David G. Harrison, and Talat Alp Ikizler
- Subjects
diuretics ,hypertension ,prehypertension ,salt intake ,sodium ,sodium MRI ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Sodium (Na+) stored in skin and muscle tissue is associated with essential hypertension. Sodium magnetic resonance imaging is a validated method of quantifying tissue stores of Na+. In this study, we evaluated tissue Na+ in patients with elevated blood pressure or stage I hypertension in response to diuretic therapy or low Na+ diet. Methods and Results In a double‐blinded, placebo‐controlled trial, patients with systolic blood pressure 120 to 139 mm Hg were randomized to low sodium diet (
- Published
- 2022
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