1. Longitudinal Study of SNCA Rep1 Polymorphism on Executive Function in Early Parkinson’s Disease
- Author
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Yi Jayne Tan, Seyed Ehsan Saffari, Yi Zhao, Ebonne Y.L. Ng, Alisa C.W. Yong, Samuel Y.E. Ng, Nicole S.Y. Chia, Xinyi Choi, Dede Heng, Shermyn Neo, Zheyu Xu, Kay Yaw Tay, Wing Lok Au, Eng-King Tan, Louis C.S. Tan, and Adeline S.L. Ng
- Subjects
Executive Function ,Cellular and Molecular Neuroscience ,Polymorphism, Genetic ,alpha-Synuclein ,Humans ,Genetic Predisposition to Disease ,Parkinson Disease ,Longitudinal Studies ,Neurology (clinical) - Abstract
The alpha-synuclein gene promoter (SNCA-Rep1) is associated with Parkinson’s disease (PD), but its relationship with performance across individual cognitive domains in early PD is unknown. This study aims to investigate Rep1 polymorphism and longitudinal change in cognition in early PD. In this longitudinal study, Rep1 allele lengths (“long” and “short”) were determined in 204 early PD patients. All participants underwent annual neuropsychological assessments and followed up for 3 years. Linear-mixed model was performed to investigate the association of Rep1 status and longitudinal change in individual cognitive domains. At 3 years, significant decline in executive function was observed in long Rep1 allele carriers vs short allele carriers, controlling for potential confounders. This is the first longitudinal study demonstrating that long Rep1 allele carriers are at higher risk for executive dysfunction in early PD.
- Published
- 2022
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