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Longitudinal Study of SNCA Rep1 Polymorphism on Executive Function in Early Parkinson’s Disease

Authors :
Yi Jayne Tan
Seyed Ehsan Saffari
Yi Zhao
Ebonne Y.L. Ng
Alisa C.W. Yong
Samuel Y.E. Ng
Nicole S.Y. Chia
Xinyi Choi
Dede Heng
Shermyn Neo
Zheyu Xu
Kay Yaw Tay
Wing Lok Au
Eng-King Tan
Louis C.S. Tan
Adeline S.L. Ng
Source :
Journal of Parkinson's Disease. 12:865-870
Publication Year :
2022
Publisher :
IOS Press, 2022.

Abstract

The alpha-synuclein gene promoter (SNCA-Rep1) is associated with Parkinson’s disease (PD), but its relationship with performance across individual cognitive domains in early PD is unknown. This study aims to investigate Rep1 polymorphism and longitudinal change in cognition in early PD. In this longitudinal study, Rep1 allele lengths (“long” and “short”) were determined in 204 early PD patients. All participants underwent annual neuropsychological assessments and followed up for 3 years. Linear-mixed model was performed to investigate the association of Rep1 status and longitudinal change in individual cognitive domains. At 3 years, significant decline in executive function was observed in long Rep1 allele carriers vs short allele carriers, controlling for potential confounders. This is the first longitudinal study demonstrating that long Rep1 allele carriers are at higher risk for executive dysfunction in early PD.

Details

ISSN :
1877718X and 18777171
Volume :
12
Database :
OpenAIRE
Journal :
Journal of Parkinson's Disease
Accession number :
edsair.doi.dedup.....9da7814f676eb948810df132280900e4
Full Text :
https://doi.org/10.3233/jpd-213029