1. Effects of Ethanol Lock Therapy on Central Line Infections and Mechanical Problems in Children With Intestinal Failure
- Author
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Kate Samela, Jasmeet S. Mokha, Zev H. Davidovics, and Karan M. Emerick
- Subjects
0301 basic medicine ,Parenteral Nutrition ,medicine.medical_specialty ,Adolescent ,Medicine (miscellaneous) ,Clinical nutrition ,03 medical and health sciences ,0302 clinical medicine ,Intestinal failure ,Internal medicine ,medicine ,Central Venous Catheters ,Humans ,Ethanol lock ,Intestinal Mucosa ,Child ,Retrospective Studies ,Central line ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Ethanol ,business.industry ,Infant ,Retrospective cohort study ,equipment and supplies ,Surgery ,Intestines ,Intestinal Diseases ,Catheter ,Parenteral nutrition ,Catheter-Related Infections ,Child, Preschool ,Cohort ,030211 gastroenterology & hepatology ,business - Abstract
Objectives: Although use of 70% ethanol lock therapy (ELT) has been shown to decrease the rate of catheter-related bloodstream infections (CRBSIs) in patients with intestinal failure and central venous catheters (CVCs), concerns have been raised about its association with higher rates of mechanical problems and CVC replacements (CVC-Rs). We sought to compare the rates of CRBSI, mechanical problems, and CVC-Rs in a cohort of pediatric patients with intestinal failure, with and without ELT (ELT+ and ELT−, respectively). Methods: Data were collected in a retrospective chart review from February 2007 to May 2014. Mann-Whitney and Wilcoxon signed-rank tests were used to compare nonparametric and paired data, respectively. Results: Twenty-nine children had 9033 catheter days (CDs). The ELT+ group (vs ELT−) had lower rate of infection and significantly fewer CVC-Rs due to infection but significantly more mechanical events and related CVC-Rs with significantly shorter mean CVC survival. In 13 children who had a p...
- Published
- 2016