Search

Your search keyword '"Maligres, Peter E."' showing total 6 results
Start Over Author "Maligres, Peter E." Journal journal of organic chemistry
6 results on '"Maligres, Peter E."'

1. Stereocontrolled preparation of a nonpeptidal (-)-spirobicyclic NK-1 receptor antagonist

Author

Maligres, Peter E., Waters, Marjorie M., Lee, Jaemoon, Reamer, Robert A., Askin, David, Ashwood, Michael S., and Cameron, Mark

Subjects
Chemistry, Organic -- Research, Peptides -- Physiological aspects, Tachykinins -- Physiological aspects, Halides -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the spirobicyclic neurokinin NK-1 receptor antagonist anipod. The synthesis of this antipode has been carried out and the results indicate that the resulting allylic halide bears the cyclopropoxy-substituted aryl group.

Published
2002

2. Preparation of (S)-3-carbethoxy-3-benzylpiperidine and the growth hormone secretagogue L-163,540

Author

Maligres, Peter E., Chartrain, Michel M., Upadhyay, Veena, Cohen, Deborah, Reamer, Robert A., Volante, R.P., Askin, David, and Reider, Paul J.

Subjects
Somatotropin -- Research, Organic compounds -- Research, Biological sciences, Chemistry
Abstract

A study was conducted to analyze the synthesis of (S)-3-carbethoxy-3-benzylpiperidine and the growth hormone secretagogue L163,540. Molecular sieves were utilized to dry solvents for anhydrous reactions. Manipulations were performed under an inert environment of nitrogen gas. High performance liquid chromatography was then carried out using a B-03-5 YMC Basic. In addition, silica gel was used to perform flash column chromatography.

Published
1998

6. A Soluble Copper(I) Source and Stable Salts of Volatile Ligands for Copper-Catalyzed C-X Couplings.

Author

Maligres, Peter E., Krska, Shane W., and Dormer, Peter G.

Subjects
*COPPER catalysts, *SALTS, *LIGANDS (Chemistry), *COUPLING agents (Chemistry), *PERFORMANCE evaluation, COPPER solubility
Abstract

A stable adduct of CuI with Bu4NI, soluble in organic solvents, has been identified as an effective catalyst for copper-catalyzed C-N and C-O couplings. In addition, stable nonhygroscopic salts of some high performance ligands (diamine MsOH salts/CuX and copper(II) diketonates) were shown to be of similar and sometimes greater reactivity compared to the literature reagents for these couplings. Furthermore, these more robust conditions result in more reproducible results. [ABSTRACT FROM AUTHOR]

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results