Stereocontrolled preparation of a nonpeptidal (-)-spirobicyclic NK-1 receptor antagonist

Authors :: Maligres, Peter E.
Waters, Marjorie M.
Lee, Jaemoon
Reamer, Robert A.
Askin, David
Ashwood, Michael S.
Cameron, Mark
Source :: Journal of Organic Chemistry. Feb 22, 2002, Vol. 67 Issue 4, p1093, 9 p.
Publication Year :: 2002
Abstract: Research has been conducted on the spirobicyclic neurokinin NK-1 receptor antagonist anipod. The synthesis of this antipode has been carried out and the results indicate that the resulting allylic halide bears the cyclopropoxy-substituted aryl group.

Subjects :: Chemistry, Organic -- Research
Peptides -- Physiological aspects
Tachykinins -- Physiological aspects
Halides -- Physiological aspects
Biological sciences
Chemistry

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