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Start Over Author "Hepperle M" Journal journal of medicinal chemistry
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1. Preparation of Phenolic Paclitaxel Metabolites

Author

Park, H., Hepperle, M., Boge, T. C., Himes, R. H., and Georg, G. I.

Abstract

The synthesis and biological evaluation of the two known phenolic metabolites of paclitaxel are described. The C3‘-phenolic metabolite 2 of paclitaxel was prepared from 7-(triethylsilyl)baccatin III (8) and enantioenriched N-benzoyl-2-azetidinone 7. The C2-phenolic metabolite 3 was synthesized from paclitaxel (1a) via selective C2 debenzoylation and reacylation.

Published
1996

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