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Preparation of Phenolic Paclitaxel Metabolites
- Source :
- Journal of Medicinal Chemistry; July 5, 1996, Vol. 39 Issue: 14 p2705-2709, 5p
- Publication Year :
- 1996
-
Abstract
- The synthesis and biological evaluation of the two known phenolic metabolites of paclitaxel are described. The C3-phenolic metabolite <BO>2 </BO>of paclitaxel was prepared from 7-(triethylsilyl)baccatin III (<BO>8</BO>) and enantioenriched N-benzoyl-2-azetidinone <BO>7</BO>. The C2-phenolic metabolite <BO>3 </BO>was synthesized from paclitaxel (<BO>1a</BO>) via selective C2 debenzoylation and reacylation.
Details
- Language :
- English
- ISSN :
- 00222623 and 15204804
- Volume :
- 39
- Issue :
- 14
- Database :
- Supplemental Index
- Journal :
- Journal of Medicinal Chemistry
- Publication Type :
- Periodical
- Accession number :
- ejs1108758