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Although the understanding of the etiology and pathogenesis of AD has been expanded in the last years, the potential association between COVID-19 and AD remains unclear.3 Importantly, some pathomechanisms related to AD are shared with COVID-19. In line with this, SARS-CoV-2 may activate glial cells, thus potentially triggering chronic neuroinflammation and neurodegeneration.3 Of note, the inflammatory response may lead to the neuronal death observed in postmortem samples of patients with COVID-19,4 as well as SARS-CoV-2 neuroinvasion may trigger neuropathological changes.5 Alzheimer's disease (AD) is the most common age-related neurodegenerative disease. Keywords: Infection; Inflammation; Immune responses; SARS coronavirus; Virus classification EN Infection Inflammation Immune responses SARS coronavirus Virus classification 833 835 3 01/21/22 20220301 NES 220301 The COVID-19 pandemic has represented an exceptional health challenge as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has acute and chronic consequences. [Extracted from the article]