1. Could first-trimester assessment of placental functions predict preeclampsia and intrauterine growth restriction? A prospective cohort study.
- Author
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Abdel Moety GA, Almohamady M, Sherif NA, Raslana AN, Mohamed TF, El Moneam HM, Mohy AM, and Youssef MA
- Subjects
- Adult, Female, Humans, Pre-Eclampsia diagnostic imaging, Pregnancy, Prospective Studies, Ultrasonography, Doppler, Ultrasonography, Prenatal, Young Adult, Chorionic Gonadotropin, beta Subunit, Human blood, Pre-Eclampsia blood, Pregnancy Trimester, First blood, Pregnancy-Associated Plasma Protein-A metabolism, Uterine Artery diagnostic imaging
- Abstract
Objective: To examine the role of first-trimester uterine artery Doppler, serum β-hCG and pregnancy-associated placental protein-A (PAPP-A) in prediction of preeclampsia and IUGR., Methods: A total of 100 pregnant women in the 11-14 weeks' gestation were examined using uterine artery Doppler, serum β-hCG and PAPP-A. All women were followed-up for development of preeclampsia or IUGR., Results: A total of 94 women completed the study of which 7 (7.4%) developed complications. Uterine artery PI and RI were significantly higher whereas serum β-hCG and PAPP-A levels were significantly reduced in patients who developed complications when compared with those who did not. Uterine artery PI had the highest sensitivity (100%) but a low specificity (56% and 45%) in prediction of preeclampsia and IUGR, respectively. Adding PAPP-A to uterine artery PI elevated the specificity into 94.44% and 95.51%, respectively. Combined PI and β-hCG elevated the specificity into 88.89% and 89.89%, respectively., Conclusion: Our study suggests that first-trimester uterine artery impedance, as measured by Doppler ultrasound as well as low serum biomarkers (β-hCG and PAPP-A) can be used for prediction of preeclampsia and IUGR. The most sensitive is uterine artery PI. Adding β-hCG to PI improves specificity in prediction of both preeclampsia and IUGR. Uterine artery PI plus PAPP-A is the best combination for prediction of both preeclampsia and IUGR.
- Published
- 2016
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