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Could first-trimester assessment of placental functions predict preeclampsia and intrauterine growth restriction? A prospective cohort study.
- Source :
-
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2016; Vol. 29 (3), pp. 413-7. Date of Electronic Publication: 2015 Jan 16. - Publication Year :
- 2016
-
Abstract
- Objective: To examine the role of first-trimester uterine artery Doppler, serum β-hCG and pregnancy-associated placental protein-A (PAPP-A) in prediction of preeclampsia and IUGR.<br />Methods: A total of 100 pregnant women in the 11-14 weeks' gestation were examined using uterine artery Doppler, serum β-hCG and PAPP-A. All women were followed-up for development of preeclampsia or IUGR.<br />Results: A total of 94 women completed the study of which 7 (7.4%) developed complications. Uterine artery PI and RI were significantly higher whereas serum β-hCG and PAPP-A levels were significantly reduced in patients who developed complications when compared with those who did not. Uterine artery PI had the highest sensitivity (100%) but a low specificity (56% and 45%) in prediction of preeclampsia and IUGR, respectively. Adding PAPP-A to uterine artery PI elevated the specificity into 94.44% and 95.51%, respectively. Combined PI and β-hCG elevated the specificity into 88.89% and 89.89%, respectively.<br />Conclusion: Our study suggests that first-trimester uterine artery impedance, as measured by Doppler ultrasound as well as low serum biomarkers (β-hCG and PAPP-A) can be used for prediction of preeclampsia and IUGR. The most sensitive is uterine artery PI. Adding β-hCG to PI improves specificity in prediction of both preeclampsia and IUGR. Uterine artery PI plus PAPP-A is the best combination for prediction of both preeclampsia and IUGR.
- Subjects :
- Adult
Female
Humans
Pre-Eclampsia diagnostic imaging
Pregnancy
Prospective Studies
Ultrasonography, Doppler
Ultrasonography, Prenatal
Young Adult
Chorionic Gonadotropin, beta Subunit, Human blood
Pre-Eclampsia blood
Pregnancy Trimester, First blood
Pregnancy-Associated Plasma Protein-A metabolism
Uterine Artery diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4954
- Volume :
- 29
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
- Publication Type :
- Academic Journal
- Accession number :
- 25594239
- Full Text :
- https://doi.org/10.3109/14767058.2014.1002763