1. Smart magnetic poly(N-isopropylacrylamide) to control the release of bio-active molecules.
- Author
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Dionigi C, Lungaro L, Goranov V, Riminucci A, Piñeiro-Redondo Y, Bañobre-López M, Rivas J, and Dediu V
- Subjects
- Cell Survival drug effects, Cells, Cultured, Human Umbilical Vein Endothelial Cells physiology, Humans, Magnetics, Materials Testing, Thermogravimetry, Vascular Endothelial Growth Factor A administration & dosage, Acrylic Resins chemistry, Delayed-Action Preparations chemical synthesis, Delayed-Action Preparations chemistry, Delayed-Action Preparations pharmacokinetics, Drug Carriers chemical synthesis, Drug Carriers chemistry, Drug Carriers pharmacokinetics, Human Umbilical Vein Endothelial Cells drug effects, Vascular Endothelial Growth Factor A pharmacokinetics
- Abstract
Thermo switchable magnetic hydrogels undoubtedly have a great potential for medical applications since they can behave as smart carriers able to transport bioactive molecules to a chosen part of the body and release them on demand via magneto-thermal activation. We report on the ability to modify the lower critical solution temperature (LCST) of poly(N-isopropylacrylamide) (PNIPAM) on demand from 32 °C to LCST ≥ 37 °C. This was achieved by the absorption of controlled amounts of magnetite nanoparticles on the polymer chains. We show, through the effect on cell viability, that the resulting magnetic PNIPAM is able to trap and to release bio-active molecules, such as cell growth factors. The activities of the released bio molecule are tested on human umbilical vein endothelial cells culture. We demonstrate that the LCST of the magnetic PNIPAM can be reached remotely via inductive heating with an alternating magnetic field. This approach on magnetic PNIPAM clearly supports appealing applications in safe biomedicine.
- Published
- 2014
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