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Smart magnetic poly(N-isopropylacrylamide) to control the release of bio-active molecules.
- Source :
-
Journal of materials science. Materials in medicine [J Mater Sci Mater Med] 2014 Oct; Vol. 25 (10), pp. 2365-71. Date of Electronic Publication: 2014 Jan 30. - Publication Year :
- 2014
-
Abstract
- Thermo switchable magnetic hydrogels undoubtedly have a great potential for medical applications since they can behave as smart carriers able to transport bioactive molecules to a chosen part of the body and release them on demand via magneto-thermal activation. We report on the ability to modify the lower critical solution temperature (LCST) of poly(N-isopropylacrylamide) (PNIPAM) on demand from 32 °C to LCST ≥ 37 °C. This was achieved by the absorption of controlled amounts of magnetite nanoparticles on the polymer chains. We show, through the effect on cell viability, that the resulting magnetic PNIPAM is able to trap and to release bio-active molecules, such as cell growth factors. The activities of the released bio molecule are tested on human umbilical vein endothelial cells culture. We demonstrate that the LCST of the magnetic PNIPAM can be reached remotely via inductive heating with an alternating magnetic field. This approach on magnetic PNIPAM clearly supports appealing applications in safe biomedicine.
- Subjects :
- Cell Survival drug effects
Cells, Cultured
Human Umbilical Vein Endothelial Cells physiology
Humans
Magnetics
Materials Testing
Thermogravimetry
Vascular Endothelial Growth Factor A administration & dosage
Acrylic Resins chemistry
Delayed-Action Preparations chemical synthesis
Delayed-Action Preparations chemistry
Delayed-Action Preparations pharmacokinetics
Drug Carriers chemical synthesis
Drug Carriers chemistry
Drug Carriers pharmacokinetics
Human Umbilical Vein Endothelial Cells drug effects
Vascular Endothelial Growth Factor A pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4838
- Volume :
- 25
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of materials science. Materials in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 24477874
- Full Text :
- https://doi.org/10.1007/s10856-014-5159-7