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Your search keyword '"de Araujo, Márcio P."' showing total 3 results
Start Over Author "de Araujo, Márcio P." Journal journal of inorganic biochemistry
3 results on '"de Araujo, Márcio P."'

3. Synthesis, characterization and cytotoxic activities of the [RuCl2(NO)(dppp)(L)]PF6 complexes.

Author

Golfeto CC, Von Poelhsitz G, Selistre-de-Araújo HS, de Araujo MP, Ellena J, Castellano EE, Lopes LG, Moreira IS, and Batista AA

Subjects
Crystallography, X-Ray, Dimethyl Sulfoxide chemistry, Drug Screening Assays, Antitumor, Electrochemical Techniques, Humans, Models, Molecular, Molecular Sequence Data, Molecular Structure, Propane chemistry, Solvents chemistry, Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Antineoplastic Agents pharmacology, Cell Line, Tumor drug effects, Phosphines chemistry, Picolines chemistry, Propane analogs & derivatives, Pyridines chemistry, Ruthenium Compounds chemical synthesis, Ruthenium Compounds chemistry, Ruthenium Compounds pharmacology
Abstract

The synthesis and characterization of ruthenium compounds of the type [RuCl(2)(NO)(dppp)(L)]PF(6) [dppp=1,3-bis(diphenylphosphino)propane; L=pyridine, 4-methylpyridine, 4-phenylpyridine and dimethyl sulfoxide] are described. The complexes were characterized by elemental analysis, UV/Vis and infrared spectroscopy, cyclic voltammetry, and X-ray crystallography for the complexes with the pyridine and 4-methylpyridine ligands. In vitro evaluation of these nitrosyl complexes revealed cytotoxic activity from 7.1 to 19.0 microM against the MDA-MB-231 breast tumor cells and showed that, in this case, they are more active than the reference metallodrug cisplatin. The 1,3-bis(diphenylphosphino)propane and the N-heterocyclic ligands alone failed to show cytotoxic activities at the concentrations tested (maximum concentration utilized=200 microM).

Published
2010
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