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Synthesis, characterization and cytotoxic activities of the [RuCl2(NO)(dppp)(L)]PF6 complexes.
- Source :
-
Journal of inorganic biochemistry [J Inorg Biochem] 2010 May; Vol. 104 (5), pp. 489-95. Date of Electronic Publication: 2010 Jan 04. - Publication Year :
- 2010
-
Abstract
- The synthesis and characterization of ruthenium compounds of the type [RuCl(2)(NO)(dppp)(L)]PF(6) [dppp=1,3-bis(diphenylphosphino)propane; L=pyridine, 4-methylpyridine, 4-phenylpyridine and dimethyl sulfoxide] are described. The complexes were characterized by elemental analysis, UV/Vis and infrared spectroscopy, cyclic voltammetry, and X-ray crystallography for the complexes with the pyridine and 4-methylpyridine ligands. In vitro evaluation of these nitrosyl complexes revealed cytotoxic activity from 7.1 to 19.0 microM against the MDA-MB-231 breast tumor cells and showed that, in this case, they are more active than the reference metallodrug cisplatin. The 1,3-bis(diphenylphosphino)propane and the N-heterocyclic ligands alone failed to show cytotoxic activities at the concentrations tested (maximum concentration utilized=200 microM).
- Subjects :
- Crystallography, X-Ray
Dimethyl Sulfoxide chemistry
Drug Screening Assays, Antitumor
Electrochemical Techniques
Humans
Models, Molecular
Molecular Sequence Data
Molecular Structure
Propane chemistry
Solvents chemistry
Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Cell Line, Tumor drug effects
Phosphines chemistry
Picolines chemistry
Propane analogs & derivatives
Pyridines chemistry
Ruthenium Compounds chemical synthesis
Ruthenium Compounds chemistry
Ruthenium Compounds pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3344
- Volume :
- 104
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of inorganic biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 20117840
- Full Text :
- https://doi.org/10.1016/j.jinorgbio.2009.12.015