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Your search keyword '"La Rosa, Salvatore"' showing total 4 results
Start Over Author "La Rosa, Salvatore" Journal journal of heterocyclic chemistry
4 results on '"La Rosa, Salvatore"'

2. Efficient Synthesis of 3,5-Dicarbamoyl-1,4-dihydropyridines from Pyridinium Salts: Key Molecules in Understanding NAD(P)+/NAD(P)H Pathways.

Author

Mellini, Paolo, De Vita, Daniela, Di Rienzo, Barbara, La Rosa, Salvatore, Padova, Alessandro, Scipione, Luigi, Tortorella, Silvano, and Friggeri, Laura

Subjects
PYRIDINE synthesis, PYRIDINIUM compounds, NICOTINAMIDE adenine dinucleotide phosphate, HYDROGEN-ion concentration, SUBSTITUENTS (Chemistry), SUSTAINABLE chemistry
Abstract

3,5-Dicarbamoyl-1,4-dihydropyridines were prepared in high yields using a green protocol by reduction of the corresponding pyridinium salts in aqueous buffered sodium dithionite solutions. The pH value is a fundamental parameter for the reduction step and depends on the nature of substituent groups at positions 1, 3, and 5 of the pyridinium salts. These 3,5-dicarbamoyl dihydropyridines show a lower tendency towards oxidation and a higher stability than N-benzyl-3-carbamoyl-1,4-dihydropyridine at low pH values. [ABSTRACT FROM AUTHOR]

Published
2015
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