Back to Search
Start Over
Efficient Synthesis of 3,5-Dicarbamoyl-1,4-dihydropyridines from Pyridinium Salts: Key Molecules in Understanding NAD(P)+/NAD(P)H Pathways.
- Source :
- Journal of Heterocyclic Chemistry; Jan2015, Vol. 52 Issue 1, p221-226, 6p
- Publication Year :
- 2015
-
Abstract
- 3,5-Dicarbamoyl-1,4-dihydropyridines were prepared in high yields using a green protocol by reduction of the corresponding pyridinium salts in aqueous buffered sodium dithionite solutions. The pH value is a fundamental parameter for the reduction step and depends on the nature of substituent groups at positions 1, 3, and 5 of the pyridinium salts. These 3,5-dicarbamoyl dihydropyridines show a lower tendency towards oxidation and a higher stability than N-benzyl-3-carbamoyl-1,4-dihydropyridine at low pH values. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0022152X
- Volume :
- 52
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Heterocyclic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 100633231
- Full Text :
- https://doi.org/10.1002/jhet.2031