1. Heyde's syndrome: A critical review of the literature.
- Author
-
Islam S, Cevik C, Islam E, Attaya H, and Nugent K
- Subjects
- Cardiac Surgical Procedures methods, Endoscopy, Gastrointestinal methods, Humans, Incidence, Morbidity, Severity of Illness Index, Syndrome, United States epidemiology, Vascular Surgical Procedures methods, Abnormalities, Multiple, Angiodysplasia diagnosis, Angiodysplasia epidemiology, Angiodysplasia therapy, Aortic Valve Stenosis diagnosis, Aortic Valve Stenosis epidemiology, Aortic Valve Stenosis therapy, Gastrointestinal Hemorrhage diagnosis, Gastrointestinal Hemorrhage epidemiology, Gastrointestinal Hemorrhage etiology
- Abstract
Heyde's syndrome is an uncommon association between aortic stenosis and gastrointestinal bleeding. Although initially described during the late 1950s, with subsequent reports of a possible link between these disorders, controversy persists regarding the incidence, pathogenesis, and treatment of this syndrome. The main disagreements center on the actual association of aortic stenosis and angiodysplasia, though other controversies include the pathogenesis of Heyde's syndrome, ranging from von Willebrand factor deficiency and age-related degeneration to mucosal ischemia and cholesterol embolization. A variety of treatment modalities of the syndrome has been applied, including medical management, endoscopic therapy, embolization, and aortic valve replacement. Here, the controversies surrounding Heyde's syndrome, which focus on pathogenesis and treatment, are reviewed with the aim of providing a clearer understanding of the syndrome and the implications for patient care.
- Published
- 2011