1. Measuring the severity of topical 5-fluorouracil toxicity.
- Author
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Korgavkar K, Firoz EF, Xiong M, Lew R, Marcolivio K, Burnside N, Dyer R, and Weinstock MA
- Subjects
- Adult, Carcinoma, Basal Cell drug therapy, Carcinoma, Squamous Cell drug therapy, Drug Eruptions etiology, Erythema chemically induced, Facial Dermatoses chemically induced, Female, Humans, Male, Middle Aged, Observer Variation, Reproducibility of Results, Severity of Illness Index, Antimetabolites, Antineoplastic adverse effects, Drug Eruptions pathology, Erythema pathology, Facial Dermatoses pathology, Fluorouracil adverse effects, Skin Neoplasms drug therapy
- Abstract
Background: Topical 5% 5-fluorouracil (5-FU) is known to cause toxicity, such as erythema, pain, and crusting/erosions., Objectives: We sought to develop a scale to measure this toxicity and test the scale for reliability., Methods: A scale was developed involving four parameters: erythema severity, percentage of face involved in erythema, crusting/erosions severity, and percentage of face involved in crusting/erosions. Thirteen raters graded 99 sets of photographs from the Veterans Affairs Keratinocyte Carcinoma Chemoprevention (VAKCC) Trial using these parameters., Results: Intraclass correlation overall for 13 raters was 0.82 (95% CI 0.77-0.86). There was no statistically significant trend in reliability by level of training in dermatology., Conclusions: This scale is a reliable method of evaluating the severity of toxicity from topical 5-fluorouracil and can be used by dermatologists and nondermatologists alike.
- Published
- 2014
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