Measuring the severity of topical 5-fluorouracil toxicity.

Authors :: Korgavkar K
Firoz EF
Xiong M
Lew R
Marcolivio K
Burnside N
Dyer R
Weinstock MA
Source :: Journal of cutaneous medicine and surgery [J Cutan Med Surg] 2014 Jul-Aug; Vol. 18 (4), pp. 229-35.
Publication Year :: 2014
Abstract: Background: Topical 5% 5-fluorouracil (5-FU) is known to cause toxicity, such as erythema, pain, and crusting/erosions.<br />Objectives: We sought to develop a scale to measure this toxicity and test the scale for reliability.<br />Methods: A scale was developed involving four parameters: erythema severity, percentage of face involved in erythema, crusting/erosions severity, and percentage of face involved in crusting/erosions. Thirteen raters graded 99 sets of photographs from the Veterans Affairs Keratinocyte Carcinoma Chemoprevention (VAKCC) Trial using these parameters.<br />Results: Intraclass correlation overall for 13 raters was 0.82 (95% CI 0.77-0.86). There was no statistically significant trend in reliability by level of training in dermatology.<br />Conclusions: This scale is a reliable method of evaluating the severity of toxicity from topical 5-fluorouracil and can be used by dermatologists and nondermatologists alike.