1. Correlation of Brain Neuropeptide (Nesfatin-1 and Orexin-A) Concentrations with Anthropometric and Biochemical Parameters in Malnourished Children
- Author
-
Yaşar Cesur, Feyza Ustabas Kahraman, Şule Terzioğlu, Aysel Vehapoglu, İlker Tolga Özgen, Rusen Dundaroz, and İŞCAN, AKIN
- Subjects
Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,orexin-A ,Thyrotropin ,Physiology ,nesfatin-1 ,Enzyme-Linked Immunosorbent Assay ,Nerve Tissue Proteins ,Kahraman F. U. , Vehapoglu A., Ozgen I. T. , Terzioglu S., Cesur Y., Dundaroz R., -Correlation of Brain Neuropeptide (Nesfatin-1 and Orexin-A) Concentrations with Anthropometric and Biochemical Parameters in Malnourished Children-, JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.7, ss.197-202, 2015 ,Child Nutrition Disorders ,Body Mass Index ,Orexin-A ,Endocrinology ,Internal medicine ,medicine ,Humans ,Nucleobindins ,Underweight children ,Vitamin B12 ,Child ,Orexins ,Anthropometry ,Receiver operating characteristic ,business.industry ,Body Weight ,Calcium-Binding Proteins ,Case-control study ,medicine.disease ,Body Height ,DNA-Binding Proteins ,Thyroxine ,Vitamin B 12 ,Malnutrition ,Case-Control Studies ,Child, Preschool ,Multivariate Analysis ,Pediatrics, Perinatology and Child Health ,Original Article ,Female ,appetite regulation ,Underweight ,medicine.symptom ,business ,Body mass index - Abstract
Objective: Malnutrition continues to be a leading cause of stunted growth in many countries. This study aimed to investigate serum nesfatin-1 and orexin-A levels in underweight children and the potential correlations of these levels with anthropometric and nutritional parameters. Methods: The study enrolled 44 prepubertal children (between 2 and 12 years of age) with thinness grades of 1-3 and 41 healthy age- and gender-matched children. The demographic, clinical and laboratory parameters including nesfatin-1 and orexin-A concentrations were compared between the two groups. The correlations of nesfatin-1 and orexin-A with biochemical and anthropometric parameters were investigated. The receiver operating characteristic (ROC) analysis were also performed for evaluating nesfatin-1 and orexin-A in distinguishing children with malnutrition from healthy controls. Results: Thyroid-stimulating hormone, vitamin B12 and insulin levels were significantly lower in the study group than controls (p=0.001, p=0.049 and p=0.033, respectively). Mean nesfatin-1 levels in the malnourished group was also significantly lower compared to the healthy controls (3871.2 ± 1608.8 vs. 5515.0 ± 3816.4 pg/mL, p=0.012). No significant difference was observed in the orexin-A levels between the two groups (malnourished vs. control groups: 1135.7 ± 306.0 vs. 1025.7 ± 361.6 pg/mL, p=0.141). Correlation analyses revealed a positive correlation of nesfatin-1 and a negative correlation of orexin-A with body mass index (BMI) z-score. ROC analysis demonstrated that nesfatin-1 and orexin-A cannot be used to distinguish children with malnutrition from healthy controls (AUC: 0.620, p=0.061 for nesfatin-1 and AUC: 0.584, p=0.190 for orexin-A). Conclusion: The positive correlation of nesfatin-1 and the negative correlation of orexin-A with BMI suggest that these neuropeptides may be a part of a protective mechanism in the maintenance of nutritional status and that they may have a role in regulating food intake in undernourished children.
- Published
- 2015