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Correlation of Brain Neuropeptide (Nesfatin-1 and Orexin-A) Concentrations with Anthropometric and Biochemical Parameters in Malnourished Children
- Source :
- Journal of Clinical Research in Pediatric Endocrinology
- Publication Year :
- 2015
- Publisher :
- Galenos Yayinevi, 2015.
-
Abstract
- Objective: Malnutrition continues to be a leading cause of stunted growth in many countries. This study aimed to investigate serum nesfatin-1 and orexin-A levels in underweight children and the potential correlations of these levels with anthropometric and nutritional parameters. Methods: The study enrolled 44 prepubertal children (between 2 and 12 years of age) with thinness grades of 1-3 and 41 healthy age- and gender-matched children. The demographic, clinical and laboratory parameters including nesfatin-1 and orexin-A concentrations were compared between the two groups. The correlations of nesfatin-1 and orexin-A with biochemical and anthropometric parameters were investigated. The receiver operating characteristic (ROC) analysis were also performed for evaluating nesfatin-1 and orexin-A in distinguishing children with malnutrition from healthy controls. Results: Thyroid-stimulating hormone, vitamin B12 and insulin levels were significantly lower in the study group than controls (p=0.001, p=0.049 and p=0.033, respectively). Mean nesfatin-1 levels in the malnourished group was also significantly lower compared to the healthy controls (3871.2 ± 1608.8 vs. 5515.0 ± 3816.4 pg/mL, p=0.012). No significant difference was observed in the orexin-A levels between the two groups (malnourished vs. control groups: 1135.7 ± 306.0 vs. 1025.7 ± 361.6 pg/mL, p=0.141). Correlation analyses revealed a positive correlation of nesfatin-1 and a negative correlation of orexin-A with body mass index (BMI) z-score. ROC analysis demonstrated that nesfatin-1 and orexin-A cannot be used to distinguish children with malnutrition from healthy controls (AUC: 0.620, p=0.061 for nesfatin-1 and AUC: 0.584, p=0.190 for orexin-A). Conclusion: The positive correlation of nesfatin-1 and the negative correlation of orexin-A with BMI suggest that these neuropeptides may be a part of a protective mechanism in the maintenance of nutritional status and that they may have a role in regulating food intake in undernourished children.
- Subjects :
- Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
orexin-A
Thyrotropin
Physiology
nesfatin-1
Enzyme-Linked Immunosorbent Assay
Nerve Tissue Proteins
Kahraman F. U. , Vehapoglu A., Ozgen I. T. , Terzioglu S., Cesur Y., Dundaroz R., -Correlation of Brain Neuropeptide (Nesfatin-1 and Orexin-A) Concentrations with Anthropometric and Biochemical Parameters in Malnourished Children-, JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.7, ss.197-202, 2015
Child Nutrition Disorders
Body Mass Index
Orexin-A
Endocrinology
Internal medicine
medicine
Humans
Nucleobindins
Underweight children
Vitamin B12
Child
Orexins
Anthropometry
Receiver operating characteristic
business.industry
Body Weight
Calcium-Binding Proteins
Case-control study
medicine.disease
Body Height
DNA-Binding Proteins
Thyroxine
Vitamin B 12
Malnutrition
Case-Control Studies
Child, Preschool
Multivariate Analysis
Pediatrics, Perinatology and Child Health
Original Article
Female
appetite regulation
Underweight
medicine.symptom
business
Body mass index
Subjects
Details
- ISSN :
- 13085727
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Research in Pediatric Endocrinology
- Accession number :
- edsair.doi.dedup.....57130e1b69d9347fe963071407fd9ee5