16 results on '"Scoccia, A."'
Search Results
2. Prognostic Assessment of HLM Score in Heart Failure Due to Ischemic Heart Disease: A Pilot Study.
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D'Amato, Andrea, Severino, Paolo, Mancone, Massimo, Mariani, Marco Valerio, Prosperi, Silvia, Colombo, Lorenzo, Myftari, Vincenzo, Cestiè, Claudia, Labbro Francia, Aurora, Germanò, Rosanna, Pierucci, Nicola, Fanisio, Francesca, Marek-Iannucci, Stefanie, De Prisco, Andrea, Scoccia, Gianmarco, Birtolo, Lucia Ilaria, Manzi, Giovanna, Lavalle, Carlo, Sardella, Gennaro, and Badagliacca, Roberto
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CORONARY disease ,MYOCARDIAL ischemia ,HEART failure ,ACUTE coronary syndrome ,PILOT projects - Abstract
Background: Ischemic heart disease (IHD) represents the main cause of heart failure (HF). A prognostic stratification of HF patients with ischemic etiology, particularly those with acute coronary syndrome (ACS), may be challenging due the variability in clinical and hemodynamic status. The aim of this study is to assess the prognostic power of the HLM score in a population of patients with ischemic HF and in a subgroup who developed HF following ACS. Methods: This is an observational, prospective, single-center study, enrolling consecutive patients with a diagnosis of ischemic HF. Patients were stratified according to the four different HLM stages of severity, and the occurrence of CV death, HFH, and worsening HF events were evaluated at 6-month follow-up. A sub-analysis was performed on patients who developed HF following ACS at admission. Results: The study included 146 patients. HLM stage predicts the occurrence of CV death (p = 0.01) and CV death/HFH (p = 0.003). Cox regression analysis confirmed HLM stage as an independent predictor of CV death (OR: 3.07; 95% IC: 1.54–6.12; p = 0.001) and CV death/HFH (OR: 2.45; 95% IC: 1.43–4.21; p = 0.001) in the total population of patients with HF due to IHD. HLM stage potentially predicts the occurrence of CV death (p < 0.001) and CV death/HFH (p < 0.001) in patients with HF following ACS at admission. Conclusions: Pathophysiological-based prognostic assessment through HLM score is a potentially promising tool for the prediction of the occurrence of CV death and CV death/HFH in ischemic HF patients and in subgroups of patients with HF following ACS at admission. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Long Stent Implantation on the Left Anterior Descending Coronary Artery at a Follow-Up of More Than Five Years.
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Sticchi, Alessandro, Tatali, Concetta, Ferraro, Massimo, Khokhar, Arif A., Scoccia, Alessandra, Cereda, Alberto, Toselli, Marco, Gallo, Francesco, Laricchia, Alessandra, Mangieri, Antonio, Grigioni, Francesco, Ussia, Gian Paolo, Giannini, Francesco, and Colombo, Antonio
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CORONARY arteries ,MYOCARDIAL infarction ,PERCUTANEOUS coronary intervention ,CARDIOVASCULAR disease related mortality - Abstract
Background: Stent implantation represents the standard of care in coronary intervention. While a short stent implanted on a focal lesion located on the left anterior descending artery (LAD) seems a reasonable alternative to an internal mammary implant, the same for long stents is still debated. Methods: We reported the long-term data of 531 consecutive patients who underwent Percutaneous Coronary Intervention (PCI) with long stents in two highly specialized centres. The main inclusion criteria were the implantation of stents longer than 30 mm on the LAD and a minimum follow-up (FU) of five years. The primary endpoint was mortality, and the secondary endpoints were any myocardial infarction (MI), target vessel and lesion revascularization (TVR and TLR, respectively), and stent thrombosis (ST) observed as definite, probable, or possible. Results: In this selected population with characteristics of complex PCI (99.1%), the long-term follow-up (mean 92.18 ± 35.5 months) estimates of all-cause death, cardiovascular death, and any myocardial infarction were 18.3%, 10.5%, and 9.3%, respectively. Both all-cause and cardiovascular deaths are significantly associated with three-vessel disease (HR 6.8; confidence of interval (CI) 95% 3.844–11.934; p < 0.001, and HR 4.7; CI 95% 2.265–9.835; p < 0.001, respectively). Target lesion (TLR) and target vessel revascularization (TVR) are associated with the presence of three-lesion disease on the LAD (HR 3.4; CI 95% 1.984–5.781; p < 0.001; HR 3.9 CI 95% 2.323–6.442; p < 0.001, respectively). Re-PCI for any cause occurred in 31.5% of patients and shows an increased risk for three-lesion stenting (HR 4.3; CI 95% 2.873–6.376; p < 0.001) and the treatment of bifurcation with two stents (HR 1.6; 95% CI 1.051–2.414; p = 0.028). Stent thrombosis rate at the 5-year FU was 4.4% (1.3% definite; 0.9% probable; 2.1% possible), including a 1.7% rate of very-late thrombosis. The stent length superior to 40 mm was not associated with poor outcomes (all-cause death p = 0.349; cardiovascular death p = 0.855; MI p = 0.691; re-PCI p = 0.234; TLR p = 0.805; TVR p = 0.087; ST p = 0.189). Conclusion: At an FU of longer than five years, patients treated with stents longer than 30 mm in their LAD showed acceptable procedural results but poor outcomes. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Impact of Parenteral Prostanoids in Pulmonary Arterial Hypertension: The Relevance of Timing.
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Papa, Silvia, Scoccia, Gianmarco, Serino, Giorgia, Adamo, Francesca Ileana, Jabbour, Jean Pierre, Caputo, Annalisa, Boromei, Michela, Filomena, Domenico, Laviola, Domenico, Maggio, Enrico, Manzi, Giovanna, Mihai, Alexandra, Recchioni, Tommaso, Sabusco, Alexandra, Valeri, Livia, Vinciullo, Sara, Vizza, Carmine Dario, and Badagliacca, Roberto
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PULMONARY arterial hypertension , *PROSTANOIDS , *TREATMENT delay (Medicine) , *ORAL medication , *CARDIAC catheterization - Abstract
Parenteral prostanoids are being recommended in pulmonary arterial hypertension (PAH) treatment, but the prognostic relevance of delayed treatment initiation is still debated. This study assessed the impact of the timing of prostacyclin treatment initiation on reducing PVR and achieving a low-risk profile in PAH patients. The study enrolled 151 patients who started on parenteral prostanoids with different treatment strategies. All patients underwent right heart catheterization, clinical evaluation, and risk assessments at baseline and after 1-year follow-up. Patients with an upfront strategy including parenteral prostanoid plus one oral drug had −5.3 ± 6.2 WU (−50 ± 19%) reduction in PVR, patients with an upfront strategy including parenteral prostanoid plus double oral drug had −12.8 ± 5.9 WU (−68 ± 17%) reduction in PVR, while patients with an add-on strategy including parenteral prostanoid after oral drugs had −3.9 ± 3.5 WU (−23 ± 19%) reduction in PVR. An upfront strategy including parenteral prostanoids was independently associated with an increased likelihood of achieving the greater reduction of PVR compared with an add-on strategy. Additionally, the greater the severity of PH at the time of diagnosis, in terms of PVR and RV reverse remodeling, the higher the probability of treatment failure. An upfront strategy including a parenteral prostanoid is associated with the highest likelihood of achieving a low-risk profile and a greater reduction of PVR compared with parenteral prostanoid as an add-on to oral treatment. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry
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De Luca, Giuseppe, primary, Algowhary, Magdy, additional, Uguz, Berat, additional, Oliveira, Dinaldo C., additional, Ganyukov, Vladimir, additional, Busljetik, Oliver, additional, Cercek, Miha, additional, Jensen, Lisette Okkels, additional, Loh, Poay Huan, additional, Calmac, Lucian, additional, Ferrer, Gerard Roura i, additional, Quadros, Alexandre, additional, Milewski, Marek, additional, Scotto D’Uccio, Fortunato, additional, von Birgelen, Clemens, additional, Versaci, Francesco, additional, Ten Berg, Jurrien, additional, Casella, Gianni, additional, Wong Sung Lung, Aaron, additional, Kala, Petr, additional, Díez Gil, José Luis, additional, Carrillo, Xavier, additional, Dirksen, Maurits, additional, Becerra Munoz, Victor, additional, Lee, Michael Kang-yin, additional, Juzar, Dafsah Arifa, additional, de Moura Joaquim, Rodrigo, additional, Paladino, Roberto, additional, Milicic, Davor, additional, Davlouros, Periklis, additional, Bakraceski, Nikola, additional, Zilio, Filippo, additional, Donazzan, Luca, additional, Kraaijeveld, Adriaan, additional, Galasso, Gennaro, additional, Arpad, Lux, additional, Marinucci, Lucia, additional, Guiducci, Vincenzo, additional, Menichelli, Maurizio, additional, Scoccia, Alessandra, additional, Yamac, Aylin Hatice, additional, Ugur Mert, Kadir, additional, Flores Rios, Xacobe, additional, Kovarnik, Tomas, additional, Kidawa, Michal, additional, Moreu, Josè, additional, Flavien, Vincent, additional, Fabris, Enrico, additional, Martínez-Luengas, Iñigo Lozano, additional, Boccalatte, Marco, additional, Bosa Ojeda, Francisco, additional, Arellano-Serrano, Carlos, additional, Caiazzo, Gianluca, additional, Cirrincione, Giuseppe, additional, Kao, Hsien-Li, additional, Sanchis Forés, Juan, additional, Vignali, Luigi, additional, Pereira, Helder, additional, Manzo-Silberman, Stephane, additional, Ordoñez, Santiago, additional, Arat Özkan, Alev, additional, Scheller, Bruno, additional, Lehitola, Heidi, additional, Teles, Rui, additional, Mantis, Christos, additional, Antti, Ylitalo, additional, Brum Silveira, João António, additional, Zoni, Cesar Rodrigo, additional, Bessonov, Ivan, additional, Uccello, Giuseppe, additional, Kochiadakis, George, additional, Alexopulos, Dimitrios, additional, Uribe, Carlos E., additional, Kanakakis, John, additional, Faurie, Benjamin, additional, Gabrielli, Gabriele, additional, Gutierrez Barrios, Alejandro, additional, Bachini, Juan Pablo, additional, Rocha, Alex, additional, Tam, Frankie C. C., additional, Rodriguez, Alfredo, additional, Lukito, Antonia Anna, additional, Saint-Joy, Veauthyelau, additional, Pessah, Gustavo, additional, Tuccillo, Andrea, additional, Ielasi, Alfonso, additional, Cortese, Giuliana, additional, Parodi, Guido, additional, Burgadha, Mohammed Abed, additional, Kedhi, Elvin, additional, Lamelas, Pablo, additional, Suryapranata, Harry, additional, Nardin, Matteo, additional, and Verdoia, Monica, additional
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- 2023
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6. Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry
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Giuseppe De Luca, Magdy Algowhary, Berat Uguz, Dinaldo C. Oliveira, Vladimir Ganyukov, Oliver Busljetik, Miha Cercek, Lisette Okkels Jensen, Poay Huan Loh, Lucian Calmac, Gerard Roura i Ferrer, Alexandre Quadros, Marek Milewski, Fortunato Scotto D’Uccio, Clemens von Birgelen, Francesco Versaci, Jurrien Ten Berg, Gianni Casella, Aaron Wong Sung Lung, Petr Kala, José Luis Díez Gil, Xavier Carrillo, Maurits Dirksen, Victor Becerra Munoz, Michael Kang-yin Lee, Dafsah Arifa Juzar, Rodrigo de Moura Joaquim, Roberto Paladino, Davor Milicic, Periklis Davlouros, Nikola Bakraceski, Filippo Zilio, Luca Donazzan, Adriaan Kraaijeveld, Gennaro Galasso, Lux Arpad, Lucia Marinucci, Vincenzo Guiducci, Maurizio Menichelli, Alessandra Scoccia, Aylin Hatice Yamac, Kadir Ugur Mert, Xacobe Flores Rios, Tomas Kovarnik, Michal Kidawa, Josè Moreu, Vincent Flavien, Enrico Fabris, Iñigo Lozano Martínez-Luengas, Marco Boccalatte, Francisco Bosa Ojeda, Carlos Arellano-Serrano, Gianluca Caiazzo, Giuseppe Cirrincione, Hsien-Li Kao, Juan Sanchis Forés, Luigi Vignali, Helder Pereira, Stephane Manzo-Silberman, Santiago Ordoñez, Alev Arat Özkan, Bruno Scheller, Heidi Lehitola, Rui Teles, Christos Mantis, Ylitalo Antti, João António Brum Silveira, Cesar Rodrigo Zoni, Ivan Bessonov, Giuseppe Uccello, George Kochiadakis, Dimitrios Alexopulos, Carlos E. Uribe, John Kanakakis, Benjamin Faurie, Gabriele Gabrielli, Alejandro Gutierrez Barrios, Juan Pablo Bachini, Alex Rocha, Frankie C. C. Tam, Alfredo Rodriguez, Antonia Anna Lukito, Veauthyelau Saint-Joy, Gustavo Pessah, Andrea Tuccillo, Alfonso Ielasi, Giuliana Cortese, Guido Parodi, Mohammed Abed Burgadha, Elvin Kedhi, Pablo Lamelas, Harry Suryapranata, Matteo Nardin, and Monica Verdoia
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ACUTE MYOCARDIAL-INFARCTION ,IMPACT ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,Age factors in disease ,PRIMARY ANGIOPLASTY ,COVID-19 ,ageing ,ST-segment elevation myocardial infarction ,General Medicine ,COVID-19 Pandemic, 2020 ,Factors d'edat en les malalties ,Infart de miocardi ,Myocardial infarction ,All institutes and research themes of the Radboud University Medical Center ,PERFUSION ,Mortalitat ,MANAGEMENT ,Pandèmia de COVID-19, 2020 ,ST-SEGMENT ELEVATION ,Mortality - Abstract
Contains fulltext : 291566.pdf (Publisher’s version ) (Open Access) BACKGROUND: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. METHODS: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March-June 2019 and 2020. Patients were divided according to age (< or ≥75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. RESULTS: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825-0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24-1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05-1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. CONCLUSIONS: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic.
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- 2023
7. Gender Difference in the Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry
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De Luca, Giuseppe, primary, Manzo-Silberman, Stephane, additional, Algowhary, Magdy, additional, Uguz, Berat, additional, Oliveira, Dinaldo C., additional, Ganyukov, Vladimir, additional, Busljetik, Oliver, additional, Cercek, Miha, additional, Okkels, Lisette, additional, Loh, Poay Huan, additional, Calmac, Lucian, additional, Ferrer, Gerard Roura i, additional, Quadros, Alexandre, additional, Milewski, Marek, additional, Scotto di Uccio, Fortunato, additional, von Birgelen, Clemens, additional, Versaci, Francesco, additional, Ten Berg, Jurrien, additional, Casella, Gianni, additional, Wong Sung Lung, Aaron, additional, Kala, Petr, additional, Díez Gil, José Luis, additional, Carrillo, Xavier, additional, Dirksen, Maurits, additional, Becerra, Victor, additional, Lee, Michael Kang-yin, additional, Juzar, Dafsah Arifa, additional, de Moura Joaquim, Rodrigo, additional, Paladino, Roberto, additional, Milicic, Davor, additional, Davlouros, Periklis, additional, Bakraceski, Nikola, additional, Zilio, Filippo, additional, Donazzan, Luca, additional, Kraaijeveld, Adriaan, additional, Galasso, Gennaro, additional, Arpad, Lux, additional, Marinucci, Lucia, additional, Guiducci, Vincenzo, additional, Menichelli, Maurizio, additional, Scoccia, Alessandra, additional, Yamac, Aylin Hatice, additional, Ugur Mert, Kadir, additional, Flores Rios, Xacobe, additional, Kovarnik, Tomas, additional, Kidawa, Michal, additional, Moreu, Josè, additional, Flavien, Vincent, additional, Fabris, Enrico, additional, Martínez-Luengas, Iñigo Lozano, additional, Boccalatte, Marco, additional, Ojeda, Francisco Bosa, additional, Arellano-Serrano, Carlos, additional, Caiazzo, Gianluca, additional, Cirrincione, Giuseppe, additional, Kao, Hsien-Li, additional, Forés, Juan Sanchis, additional, Vignali, Luigi, additional, Pereira, Helder, additional, Ordoñez, Santiago, additional, Arat Özkan, Alev, additional, Scheller, Bruno, additional, Lehtola, Heidi, additional, Teles, Rui, additional, Mantis, Christos, additional, Antti, Ylitalo, additional, Brum Silveira, João António, additional, Zoni, Cesar Rodrigo, additional, Bessonov, Ivan, additional, Uccello, Giuseppe, additional, Kochiadakis, George, additional, Alexopulos, Dimitrios, additional, Uribe, Carlos E., additional, Kanakakis, John, additional, Faurie, Benjamin, additional, Gabrielli, Gabriele, additional, Barrios, Alejandro Gutierrez, additional, Bachini, Juan Pablo, additional, Rocha, Alex, additional, Tam, Frankie C. C., additional, Rodriguez, Alfredo, additional, Lukito, Antonia Anna, additional, Saint-Joy, Veauthyelau, additional, Pessah, Gustavo, additional, Tuccillo, Andrea, additional, Ielasi, Alfonso, additional, Cortese, Giuliana, additional, Parodi, Guido, additional, Bouraghda, Mohamed Abed, additional, Moura, Marcia, additional, Kedhi, Elvin, additional, Lamelas, Pablo, additional, Suryapranata, Harry, additional, Nardin, Matteo, additional, and Verdoia, Monica, additional
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- 2023
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8. Impact of Smoking Status on Mortality in STEMI Patients Undergoing Mechanical Reperfusion for STEMI: Insights from the ISACS–STEMI COVID-19 Registry
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De Luca, Giuseppe, primary, Algowhary, Magdy, additional, Uguz, Berat, additional, Oliveira, Dinaldo, additional, Ganyukov, Vladimir, additional, Zimbakov, Zan, additional, Cercek, Miha, additional, Jensen, Lisette, additional, Loh, Poay, additional, Calmac, Lucian, additional, Ferrer, Gerard, additional, Quadros, Alexandre, additional, Milewski, Marek, additional, Scotto D’Uccio, Fortunato, additional, von Birgelen, Clemens, additional, Versaci, Francesco, additional, Ten Berg, Jurrien, additional, Casella, Gianni, additional, Wong Sung Lung, Aaron, additional, Kala, Petr, additional, Díez Gil, José, additional, Carrillo, Xavier, additional, Dirksen, Maurits, additional, Becerra-Munoz, Victor, additional, Lee, Michael, additional, Juzar, Dafsah, additional, Joaquim, Rodrigo, additional, Paladino, Roberto, additional, Milicic, Davor, additional, Davlouros, Periklis, additional, Bakraceski, Nikola, additional, Zilio, Filippo, additional, Donazzan, Luca, additional, Kraaijeveld, Adriaan, additional, Galasso, Gennaro, additional, Arpad, Lux, additional, Lucia, Marinucci, additional, Vincenzo, Guiducci, additional, Menichelli, Maurizio, additional, Scoccia, Alessandra, additional, Yamac, Aylin, additional, Ugur Mert, Kadir, additional, Flores Rios, Xacobe, additional, Kovarnik, Tomas, additional, Kidawa, Michal, additional, Moreu, Josè, additional, Vincent, Flavien, additional, Fabris, Enrico, additional, Martínez-Luengas, Iñigo, additional, Boccalatte, Marco, additional, Bosa Ojeda, Francisco, additional, Arellano-Serrano, Carlos, additional, Caiazzo, Gianluca, additional, Cirrincione, Giuseppe, additional, Kao, Hsien-Li, additional, Sanchis Forés, Juan, additional, Vignali, Luigi, additional, Pereira, Helder, additional, Manzo, Stephane, additional, Ordoñez, Santiago, additional, Özkan, Alev, additional, Scheller, Bruno, additional, Lehtola, Heidi, additional, Teles, Rui, additional, Mantis, Christos, additional, Antti, Ylitalo, additional, Silveira, João, additional, Zoni, Rodrigo, additional, Bessonov, Ivan, additional, Savonitto, Stefano, additional, Kochiadakis, George, additional, Alexopulos, Dimitrios, additional, Uribe, Carlos, additional, Kanakakis, John, additional, Faurie, Benjamin, additional, Gabrielli, Gabriele, additional, Barrios, Alejandro, additional, Bachini, Juan, additional, Rocha, Alex, additional, Tam, Frankie, additional, Rodriguez, Alfredo, additional, Lukito, Antonia, additional, Saint-Joy, Veauthyelau, additional, Pessah, Gustavo, additional, Tuccillo, Andrea, additional, Cortese, Giuliana, additional, Parodi, Guido, additional, Bouraghda, Mohamed, additional, Kedhi, Elvin, additional, Lamelas, Pablo, additional, Suryapranata, Harry, additional, Nardin, Matteo, additional, and Verdoia, Monica, additional
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- 2022
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9. The Incidence and Impact of In-Hospital Bleeding in Patients with Acute Coronary Syndrome during the COVID-19 Pandemic
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Licordari, Roberto, primary, Sticchi, Alessandro, additional, Mancuso, Filippo, additional, Caracciolo, Alessandro, additional, Muscoli, Saverio, additional, Iacovelli, Fortunato, additional, Ruggiero, Rossella, additional, Scoccia, Alessandra, additional, Cammalleri, Valeria, additional, Pavani, Marco, additional, Loffi, Marco, additional, Scordino, Domenico, additional, Ferro, Jayme, additional, Rognoni, Andrea, additional, Buono, Andrea, additional, Nava, Stefano, additional, Albani, Stefano, additional, Colaiori, Iginio, additional, Zilio, Filippo, additional, Borghesi, Marco, additional, Regazzoni, Valentina, additional, Benenati, Stefano, additional, Pescetelli, Fabio, additional, De Marzo, Vincenzo, additional, Mannarini, Antonia, additional, Spione, Francesco, additional, Baldassarre, Doronzo, additional, De Benedictis, Michele, additional, Bonmassari, Roberto, additional, Danzi, Gian Battista, additional, Galli, Mario, additional, Ielasi, Alfonso, additional, Musumeci, Giuseppe, additional, Tomai, Fabrizio, additional, Pasceri, Vincenzo, additional, Porto, Italo, additional, Patti, Giuseppe, additional, Campo, Gianluca, additional, Colombo, Antonio, additional, Micari, Antonio, additional, Giannini, Francesco, additional, and Costa, Francesco, additional
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- 2022
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10. Computational Simulator Models and Invasive Hemodynamic Monitoring as Tools for Precision Medicine in Pulmonary Arterial Hypertension
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Giovanna Manzi, Cristiano Miotti, Marco Valerio Mariani, Silvia Papa, Federico Luongo, Gianmarco Scoccia, Beatrice De Lazzari, Claudio De Lazzari, Raymond L. Benza, Francesco Fedele, Carmine Dario Vizza, and Roberto Badagliacca
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implantable hemodynamic monitors ,big data ,computational models ,precision medicine ,pulmonary arterial hypertension ,Perspective ,Medicine ,General Medicine - Abstract
Precision medicine, providing the right therapeutic strategy for the right patient, could revolutionize management and prognosis of patients affected by cardiovascular diseases. Big data and artificial intelligence are pivotal for the realization of this ambitious design. In the setting of pulmonary arterial hypertension (PAH), the use of computational models and data derived from ambulatory implantable hemodynamic monitors could provide useful information for tailored treatment, as requested by precision medicine.
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- 2021
11. Computational Simulator Models and Invasive Hemodynamic Monitoring as Tools for Precision Medicine in Pulmonary Arterial Hypertension
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Manzi, Giovanna, primary, Miotti, Cristiano, additional, Mariani, Marco Valerio, additional, Papa, Silvia, additional, Luongo, Federico, additional, Scoccia, Gianmarco, additional, De Lazzari, Beatrice, additional, De Lazzari, Claudio, additional, Benza, Raymond L., additional, Fedele, Francesco, additional, Vizza, Carmine Dario, additional, and Badagliacca, Roberto, additional
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- 2021
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12. Peripheral Arterial Stiffness in Acute Pulmonary Embolism and Pulmonary Hypertension at Short-Term Follow-Up
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Cristiano Miotti, Francesco Fedele, Francesco Ciciarello, Silvia Papa, Claudia Malerba, Giovanna Manzi, Giulia Manguso, Roberto Badagliacca, Nadia Cedrone, Annalisa Caputo, Susanna Sciomer, Serena Valentini, Gianmarco Scoccia, Carmine Dario Vizza, Giulia Benedetti, Elena Sofia Canuti, Federica Toto, and Federico Luongo
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medicine.medical_specialty ,pulmonary embolism ,Physical examination ,030204 cardiovascular system & hematology ,Article ,chronic thromboembolic pulmonary hypertension ,03 medical and health sciences ,arterial stiff- ness ,0302 clinical medicine ,Internal medicine ,medicine ,Hospital discharge ,cardio ankle vascular index ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,Pulmonary hypertension ,Peripheral ,Pulmonary embolism ,arterial stiffness ,030228 respiratory system ,Cardiology ,Arterial stiffness ,Medicine ,Chronic thromboembolic pulmonary hypertension ,Complication ,business - Abstract
Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe and under-recognized complication of acute pulmonary embolism (PE). Forty consecutive patients with acute PE (Group 1), predominantly female (22, 55%) with a mean age of 69 ± 15 years, were matched for demographic data with 40 healthy subjects (Group 2), 40 systemic hypertension patients (Group 3) and 45 prevalent idiopathic pulmonary arterial hypertension (IPAH) patients (Group 4). The baseline evaluation included physical examination, NYHA/WHO functional class, right heart catheterization (RHC) limited to IPAH patients, echocardiographic assessment and systemic arterial stiffness measurement by cardio-ankle vascular index (CAVI). Patients with PE underwent an echocardiographic evaluation within 1 month from hospital discharge (median 27 days, IQR 21–30) to assess the echo-derived probability of PH. The CAVI values were significantly higher in the PE and IPAH groups compared with the others (Group 1 vs. Group 2, p <, 0.001, Group 1 vs. Group 3, p <, Group 1 vs. Group 4, p = ns, Group 4 vs. Group 2, p <, Group 4 vs. Group 3, p <, Group 2 vs. Group 3, p = ns). The predicted probability of echocardiography-derived high-risk criteria of PH increases for any unit increase of CAVI (OR 9.0, C.I.3.9–20.5, p = 0.0001). The PE patients with CAVI ≥ 9.0 at the time of hospital discharge presented an increased probability of PH. This study highlights a possible positive predictive role of CAVI as an early marker for the development of CTEPH.
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- 2021
13. Peripheral Arterial Stiffness in Acute Pulmonary Embolism and Pulmonary Hypertension at Short-Term Follow-Up
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Papa, Silvia, primary, Miotti, Cristiano, additional, Manzi, Giovanna, additional, Scoccia, Gianmarco, additional, Luongo, Federico, additional, Toto, Federica, additional, Malerba, Claudia, additional, Cedrone, Nadia, additional, Canuti, Elena Sofia, additional, Caputo, Annalisa, additional, Manguso, Giulia, additional, Valentini, Serena, additional, Sciomer, Susanna, additional, Ciciarello, Francesco, additional, Benedetti, Giulia, additional, Fedele, Francesco, additional, Vizza, Carmine Dario, additional, and Badagliacca, Roberto, additional
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- 2021
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14. The Growing Role of Echocardiography in Pulmonary Arterial Hypertension Risk Stratification: The Missing Piece
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Miotti, Cristiano, primary, Papa, Silvia, additional, Manzi, Giovanna, additional, Scoccia, Gianmarco, additional, Luongo, Federico, additional, Toto, Federica, additional, Malerba, Claudia, additional, Cedrone, Nadia, additional, Sciomer, Susanna, additional, Ciciarello, Francesco, additional, Fedele, Francesco, additional, Vizza, Carmine Dario, additional, and Badagliacca, Roberto, additional
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- 2021
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15. Computational Simulator Models and Invasive Hemodynamic Monitoring as Tools for Precision Medicine in Pulmonary Arterial Hypertension.
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Manzi, Giovanna, Miotti, Cristiano, Mariani, Marco Valerio, Papa, Silvia, Luongo, Federico, Scoccia, Gianmarco, De Lazzari, Beatrice, De Lazzari, Claudio, Benza, Raymond L., Fedele, Francesco, Vizza, Carmine Dario, and Badagliacca, Roberto
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PULMONARY arterial hypertension ,HEMODYNAMIC monitoring ,INDIVIDUALIZED medicine ,PULMONOLOGY ,PATIENTS' rights - Abstract
Precision medicine, providing the right therapeutic strategy for the right patient, could revolutionize management and prognosis of patients affected by cardiovascular diseases. Big data and artificial intelligence are pivotal for the realization of this ambitious design. In the setting of pulmonary arterial hypertension (PAH), the use of computational models and data derived from ambulatory implantable hemodynamic monitors could provide useful information for tailored treatment, as requested by precision medicine. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
16. Long Stent Implantation on the Left Anterior Descending Coronary Artery at a Follow-Up of More Than Five Years.
- Author
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Sticchi A, Tatali C, Ferraro M, Khokhar AA, Scoccia A, Cereda A, Toselli M, Gallo F, Laricchia A, Mangieri A, Grigioni F, Ussia GP, Giannini F, and Colombo A
- Abstract
Background: Stent implantation represents the standard of care in coronary intervention. While a short stent implanted on a focal lesion located on the left anterior descending artery (LAD) seems a reasonable alternative to an internal mammary implant, the same for long stents is still debated., Methods: We reported the long-term data of 531 consecutive patients who underwent Percutaneous Coronary Intervention (PCI) with long stents in two highly specialized centres. The main inclusion criteria were the implantation of stents longer than 30 mm on the LAD and a minimum follow-up (FU) of five years. The primary endpoint was mortality, and the secondary endpoints were any myocardial infarction (MI), target vessel and lesion revascularization (TVR and TLR, respectively), and stent thrombosis (ST) observed as definite, probable, or possible., Results: In this selected population with characteristics of complex PCI (99.1%), the long-term follow-up (mean 92.18 ± 35.5 months) estimates of all-cause death, cardiovascular death, and any myocardial infarction were 18.3%, 10.5%, and 9.3%, respectively. Both all-cause and cardiovascular deaths are significantly associated with three-vessel disease (HR 6.8; confidence of interval (CI) 95% 3.844-11.934; p < 0.001, and HR 4.7; CI 95% 2.265-9.835; p < 0.001, respectively). Target lesion (TLR) and target vessel revascularization (TVR) are associated with the presence of three-lesion disease on the LAD (HR 3.4; CI 95% 1.984-5.781; p < 0.001; HR 3.9 CI 95% 2.323-6.442; p < 0.001, respectively). Re-PCI for any cause occurred in 31.5% of patients and shows an increased risk for three-lesion stenting (HR 4.3; CI 95% 2.873-6.376; p < 0.001) and the treatment of bifurcation with two stents (HR 1.6; 95% CI 1.051-2.414; p = 0.028). Stent thrombosis rate at the 5-year FU was 4.4% (1.3% definite; 0.9% probable; 2.1% possible), including a 1.7% rate of very-late thrombosis. The stent length superior to 40 mm was not associated with poor outcomes (all-cause death p = 0.349; cardiovascular death p = 0.855; MI p = 0.691; re-PCI p = 0.234; TLR p = 0.805; TVR p = 0.087; ST p = 0.189)., Conclusion: At an FU of longer than five years, patients treated with stents longer than 30 mm in their LAD showed acceptable procedural results but poor outcomes.
- Published
- 2023
- Full Text
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