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Peripheral Arterial Stiffness in Acute Pulmonary Embolism and Pulmonary Hypertension at Short-Term Follow-Up
- Source :
- Journal of Clinical Medicine, Journal of Clinical Medicine, Vol 10, Iss 3008, p 3008 (2021), Volume 10, Issue 14
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe and under-recognized complication of acute pulmonary embolism (PE). Forty consecutive patients with acute PE (Group 1), predominantly female (22, 55%) with a mean age of 69 ± 15 years, were matched for demographic data with 40 healthy subjects (Group 2), 40 systemic hypertension patients (Group 3) and 45 prevalent idiopathic pulmonary arterial hypertension (IPAH) patients (Group 4). The baseline evaluation included physical examination, NYHA/WHO functional class, right heart catheterization (RHC) limited to IPAH patients, echocardiographic assessment and systemic arterial stiffness measurement by cardio-ankle vascular index (CAVI). Patients with PE underwent an echocardiographic evaluation within 1 month from hospital discharge (median 27 days<br />IQR 21–30) to assess the echo-derived probability of PH. The CAVI values were significantly higher in the PE and IPAH groups compared with the others (Group 1 vs. Group 2, p &lt<br />0.001<br />Group 1 vs. Group 3, p &lt<br />Group 1 vs. Group 4, p = ns<br />Group 4 vs. Group 2, p &lt<br />Group 4 vs. Group 3, p &lt<br />Group 2 vs. Group 3, p = ns). The predicted probability of echocardiography-derived high-risk criteria of PH increases for any unit increase of CAVI (OR 9.0<br />C.I.3.9–20.5<br />p = 0.0001). The PE patients with CAVI ≥ 9.0 at the time of hospital discharge presented an increased probability of PH. This study highlights a possible positive predictive role of CAVI as an early marker for the development of CTEPH.
- Subjects :
- medicine.medical_specialty
pulmonary embolism
Physical examination
030204 cardiovascular system & hematology
Article
chronic thromboembolic pulmonary hypertension
03 medical and health sciences
arterial stiff- ness
0302 clinical medicine
Internal medicine
medicine
Hospital discharge
cardio ankle vascular index
medicine.diagnostic_test
business.industry
General Medicine
medicine.disease
Pulmonary hypertension
Peripheral
Pulmonary embolism
arterial stiffness
030228 respiratory system
Cardiology
Arterial stiffness
Medicine
Chronic thromboembolic pulmonary hypertension
Complication
business
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 10
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....e78a1f9a283a3f3e5c91b8d669b9ee4c