1. Role of Wnt/β‐catenin signaling regulatory microRNAs in the pathogenesis of colorectal cancer
- Author
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Farzad Rahmani, Shahrokh Naseri, Seyed Isaac Hashemy, and Amir Avan
- Subjects
0301 basic medicine ,Physiology ,Angiogenesis ,Colorectal cancer ,Clinical Biochemistry ,Metastasis ,Causes of cancer ,03 medical and health sciences ,0302 clinical medicine ,microRNA ,Animals ,Humans ,Medicine ,Wnt Signaling Pathway ,business.industry ,Wnt signaling pathway ,LRP6 ,LRP5 ,Cell Biology ,Prognosis ,medicine.disease ,Gene Expression Regulation, Neoplastic ,MicroRNAs ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer research ,Colorectal Neoplasms ,business - Abstract
Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. In more than 90% of all CRC patients, the master oncogenic Ras-Wnt signaling axis is over-activated. MicroRNAs (miRNAs) are potential novel diagnostic and prognostic biomarkers as well as therapeutic targets for several cancers including lung, breast, gastric, and colorectal cancers. Oncogenic or tumor suppressor miRNAs modulate tumor cells proliferation, cell cycle progression, angiogenesis, invasion, and metastasis through regulating oncogenic pathways including Wnt/β-catenin signaling. This review summarizes the current knowledge about the role of Wnt/β-catenin signaling regulatory miRNAs in the pathogenesis of colorectal cancer for a better understanding and hence a better management of this disease.
- Published
- 2017
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