Back to Search Start Over

Role of Wnt/β‐catenin signaling regulatory microRNAs in the pathogenesis of colorectal cancer

Authors :
Farzad Rahmani
Shahrokh Naseri
Seyed Isaac Hashemy
Amir Avan
Source :
Journal of Cellular Physiology. 233:811-817
Publication Year :
2017
Publisher :
Wiley, 2017.

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. In more than 90% of all CRC patients, the master oncogenic Ras-Wnt signaling axis is over-activated. MicroRNAs (miRNAs) are potential novel diagnostic and prognostic biomarkers as well as therapeutic targets for several cancers including lung, breast, gastric, and colorectal cancers. Oncogenic or tumor suppressor miRNAs modulate tumor cells proliferation, cell cycle progression, angiogenesis, invasion, and metastasis through regulating oncogenic pathways including Wnt/β-catenin signaling. This review summarizes the current knowledge about the role of Wnt/β-catenin signaling regulatory miRNAs in the pathogenesis of colorectal cancer for a better understanding and hence a better management of this disease.

Details

ISSN :
10974652 and 00219541
Volume :
233
Database :
OpenAIRE
Journal :
Journal of Cellular Physiology
Accession number :
edsair.doi.dedup.....578888cef5e330a766ce7a42b4800ac1
Full Text :
https://doi.org/10.1002/jcp.25897