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Role of Wnt/β‐catenin signaling regulatory microRNAs in the pathogenesis of colorectal cancer
- Source :
- Journal of Cellular Physiology. 233:811-817
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. In more than 90% of all CRC patients, the master oncogenic Ras-Wnt signaling axis is over-activated. MicroRNAs (miRNAs) are potential novel diagnostic and prognostic biomarkers as well as therapeutic targets for several cancers including lung, breast, gastric, and colorectal cancers. Oncogenic or tumor suppressor miRNAs modulate tumor cells proliferation, cell cycle progression, angiogenesis, invasion, and metastasis through regulating oncogenic pathways including Wnt/β-catenin signaling. This review summarizes the current knowledge about the role of Wnt/β-catenin signaling regulatory miRNAs in the pathogenesis of colorectal cancer for a better understanding and hence a better management of this disease.
- Subjects :
- 0301 basic medicine
Physiology
Angiogenesis
Colorectal cancer
Clinical Biochemistry
Metastasis
Causes of cancer
03 medical and health sciences
0302 clinical medicine
microRNA
Animals
Humans
Medicine
Wnt Signaling Pathway
business.industry
Wnt signaling pathway
LRP6
LRP5
Cell Biology
Prognosis
medicine.disease
Gene Expression Regulation, Neoplastic
MicroRNAs
030104 developmental biology
030220 oncology & carcinogenesis
Cancer research
Colorectal Neoplasms
business
Subjects
Details
- ISSN :
- 10974652 and 00219541
- Volume :
- 233
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular Physiology
- Accession number :
- edsair.doi.dedup.....578888cef5e330a766ce7a42b4800ac1
- Full Text :
- https://doi.org/10.1002/jcp.25897