1. Draft genome sequences of Helicobacter pylori isolates from Malaysia, cultured from patients with functional dyspepsia and gastric cancer
- Author
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Thevakumar Kavitha, Liang Chung Tay, Halimah Alias, Stephen Rudd, Norzawani Buang M. Yassin, Nadeem O. Kaakoush, HueyTyng Lee, Eng Guan Chua, Nur Siti Khadijah Ramli, Khean-Lee Goh, Joanne Mason, Xinsheng Teh, Mun Fai Loke, Hazel M. Mitchell, Jamuna Vadivelu, S.P. Gunaletchumy, Nur Zafirah Zaidan, and Yalda Khosravi
- Subjects
DNA, Bacterial ,Biopsy ,Population structure ,Molecular Sequence Data ,Microbiology ,Genome ,Helicobacter Infections ,Stomach Neoplasms ,medicine ,Humans ,Risk factor ,Dyspepsia ,Molecular Biology ,Genetic diversity ,biology ,medicine.diagnostic_test ,Helicobacter pylori ,Malaysia ,Cancer ,Sequence Analysis, DNA ,medicine.disease ,biology.organism_classification ,digestive system diseases ,Lymphoma ,Genome Announcements ,Genome, Bacterial - Abstract
Helicobacter pylori is the main bacterial causative agent of gastroduodenal disorders and a risk factor for gastric adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma. The draft genomes of 10 closely related H. pylori isolates from the multiracial Malaysian population will provide an insight into the genetic diversity of isolates in Southeast Asia. These isolates were cultured from gastric biopsy samples from patients with functional dyspepsia and gastric cancer. The availability of this genomic information will provide an opportunity for examining the evolution and population structure of H. pylori isolates from Southeast Asia, where the East meets the West.
- Published
- 2012