1. Kalshiolin A, new lignan from Kalimeris shimadai.
- Author
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Wang, Guo-Kai, Jin, Wen-Fang, Zhang, Nan, Wang, Gang, Cheng, Yung-Yi, Morris-Natschke, Susan L., Goto, Masuo, Zhou, Zhong-Yu, Liu, Jin-Song, and Lee, Kuo-Hsiung
- Subjects
CELL lines ,CHROMATOGRAPHIC analysis ,DRUG toxicity ,LIGNANS ,MEDICINAL plants ,MOLECULAR structure ,RESEARCH funding ,PHYTOCHEMICALS ,PLANT extracts - Abstract
The Asian plant Kalimeris shimadai has been used as food and ethnologic medicine for over a thousand years. In this study, we isolated and identified one new lignan, kalshiolin A (1), and 12 known lignans (2–13). The structures were characterized by the comprehensive analyses of spectroscopic data (HR-ESI-MS, IR, 1D, and 2D-NMR) and the absolute configuration of 1 was determined from ECD calculations. The new compound 1 was also screened for cytotoxic activity but did not show significant potency (IC
50 35.9–43.3 μM) against A549, MDA-MB-231, MCF7, KB, and KB-VIN cell lines. [ABSTRACT FROM AUTHOR]- Published
- 2020
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