1. Frequency of Cardiovascular Genetic Risk Factors in a Calabrian Population and Their Effects on Dementia
- Author
-
Maria Gabriella Muraca, Livia Bernardi, Franca Vasso, Giuseppe Passarino, Raffaele Maletta, Alberto Montesanto, Giusi Torchia, Maria Elena Conidi, Rosanna Colao, Amalia C. Bruni, Nicoletta Smirne, Chiara Cupidi, Raffaele Di Lorenzo, Maura Gallo, Valentina Laganà, Sabrina A.M. Curcio, Francesca Frangipane, Gianfranco Puccio, Maria Anfossi, Giuseppina Rose, and Maria Mirabelli
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Population ,Apolipoprotein E4 ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Gene Frequency ,Alzheimer Disease ,Risk Factors ,Internal medicine ,medicine ,Dementia ,Humans ,Risk factor ,Vascular dementia ,education ,Allele frequency ,Aged ,Aged, 80 and over ,education.field_of_study ,Polymorphism, Genetic ,business.industry ,General Neuroscience ,Dementia, Vascular ,Case-control study ,General Medicine ,Middle Aged ,medicine.disease ,Cholesterol Ester Transfer Proteins ,Psychiatry and Mental health ,Clinical Psychology ,030104 developmental biology ,Italy ,Case-Control Studies ,Frontotemporal Dementia ,Female ,Geriatrics and Gerontology ,Alzheimer's disease ,business ,030217 neurology & neurosurgery ,Frontotemporal dementia - Abstract
Background Several genetic variants playing a key role in cholesterol levels, blood pressure, and vascular dysfunction influence the risk of Alzheimer's disease (AD) and vascular dementia (VaD). The many meta-analysis studies carried out on large numbers of samples in different populations have not provided clear results to date, because a trans-ethnic shift of risk genotypes in different populations is often observed. Objectives To determine genotypes allele frequencies of the polymorphisms most frequently identified to be correlated with cardio-cerebrovascular disease and AD in a Southern Italy population and to investigate their possible association with dementia. Methods The genotype and allele frequencies of 13 cardio-cerebrovascular risk polymorphisms were assessed and their possible association with dementia was investigated in a case-control study, including 221 consecutive unrelated subjects diagnosed with dementia (120 subjects affected by AD, 55 by frontotemporal dementia, and 33 by vascular dementia) and 218 matched controls of Calabrian origin. Results Carriers of at least one APOEɛ4 allele resulted to be at higher risk of AD [OR(95% CI) = 2.721(1.477-5.011)] and VaD [OR(95% CI) = 6.205(2.356-16.342)] compared to non-carriers. Individuals with the IV genotype of the CETP polymorphism were more likely to have AD [OR(95% CI) = 2.427(1.364-4.319)] and VaD [OR(95% CI) = 3.649(1.455-9.152)] compared to subjects with the II-VV genotypes. Conclusion CETP I405V polymorphism is likely a risk factor for AD and VaD in our cohort, independent of APOEɛ4 status. Unmodifiable genetic risk factors should be taken into account to promote a healthy lifestyle to prevent dementia.
- Published
- 2018