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Frequency of Cardiovascular Genetic Risk Factors in a Calabrian Population and Their Effects on Dementia
- Source :
- Journal of Alzheimer's disease : JAD. 61(3)
- Publication Year :
- 2018
-
Abstract
- Background Several genetic variants playing a key role in cholesterol levels, blood pressure, and vascular dysfunction influence the risk of Alzheimer's disease (AD) and vascular dementia (VaD). The many meta-analysis studies carried out on large numbers of samples in different populations have not provided clear results to date, because a trans-ethnic shift of risk genotypes in different populations is often observed. Objectives To determine genotypes allele frequencies of the polymorphisms most frequently identified to be correlated with cardio-cerebrovascular disease and AD in a Southern Italy population and to investigate their possible association with dementia. Methods The genotype and allele frequencies of 13 cardio-cerebrovascular risk polymorphisms were assessed and their possible association with dementia was investigated in a case-control study, including 221 consecutive unrelated subjects diagnosed with dementia (120 subjects affected by AD, 55 by frontotemporal dementia, and 33 by vascular dementia) and 218 matched controls of Calabrian origin. Results Carriers of at least one APOEɛ4 allele resulted to be at higher risk of AD [OR(95% CI) = 2.721(1.477-5.011)] and VaD [OR(95% CI) = 6.205(2.356-16.342)] compared to non-carriers. Individuals with the IV genotype of the CETP polymorphism were more likely to have AD [OR(95% CI) = 2.427(1.364-4.319)] and VaD [OR(95% CI) = 3.649(1.455-9.152)] compared to subjects with the II-VV genotypes. Conclusion CETP I405V polymorphism is likely a risk factor for AD and VaD in our cohort, independent of APOEɛ4 status. Unmodifiable genetic risk factors should be taken into account to promote a healthy lifestyle to prevent dementia.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Population
Apolipoprotein E4
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Gene Frequency
Alzheimer Disease
Risk Factors
Internal medicine
medicine
Dementia
Humans
Risk factor
Vascular dementia
education
Allele frequency
Aged
Aged, 80 and over
education.field_of_study
Polymorphism, Genetic
business.industry
General Neuroscience
Dementia, Vascular
Case-control study
General Medicine
Middle Aged
medicine.disease
Cholesterol Ester Transfer Proteins
Psychiatry and Mental health
Clinical Psychology
030104 developmental biology
Italy
Case-Control Studies
Frontotemporal Dementia
Female
Geriatrics and Gerontology
Alzheimer's disease
business
030217 neurology & neurosurgery
Frontotemporal dementia
Subjects
Details
- ISSN :
- 18758908
- Volume :
- 61
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's disease : JAD
- Accession number :
- edsair.doi.dedup.....df336e81a258ccfa4593c0072345f70f