1. NB-02 Protects Neurons and Astrocytes from Oligomeric Amyloid-β-Mediated Damage.
- Author
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Miller, Morgan R., Lariviere, Lavender, Pagnier, Guillaume J., Aygar, Sema, Wieckiewicz, Natalia, Maesako, Masato, Bacskai, Brian J., and Kastanenka, Ksenia V.
- Subjects
NEURONS ,ALZHEIMER'S disease ,ASTROCYTES ,MEDICAL botany ,NEURODEGENERATION ,CELL death - Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disease with limited therapeutic strategies. NB-02 is a novel botanical drug that has shown promise as a protective and therapeutic treatment for AD in an APP/PS1 preclinical mouse model. In this paper, we investigate the underlying mechanisms by which NB-02 provides these therapeutic advantages using in vitro neuron-astrocyte co-cultures. Pretreatment with NB-02 prevented pathological calcium elevations in neurons and astrocytes after application of toxic soluble amyloid-β (Aβ) oligomers. NB-02 also prevented cell death associated with the addition of soluble Aβ oligomers suggesting NB-02 is effective at protecting both neurons and astrocytes from Aβ-mediated damage. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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