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NB-02 Protects Neurons and Astrocytes from Oligomeric Amyloid-β-Mediated Damage.
- Source :
- Journal of Alzheimer's Disease; 2024, Vol. 99 Issue 2, p477-483, 7p
- Publication Year :
- 2024
-
Abstract
- Alzheimer's disease (AD) is a progressive neurodegenerative disease with limited therapeutic strategies. NB-02 is a novel botanical drug that has shown promise as a protective and therapeutic treatment for AD in an APP/PS1 preclinical mouse model. In this paper, we investigate the underlying mechanisms by which NB-02 provides these therapeutic advantages using in vitro neuron-astrocyte co-cultures. Pretreatment with NB-02 prevented pathological calcium elevations in neurons and astrocytes after application of toxic soluble amyloid-β (Aβ) oligomers. NB-02 also prevented cell death associated with the addition of soluble Aβ oligomers suggesting NB-02 is effective at protecting both neurons and astrocytes from Aβ-mediated damage. [ABSTRACT FROM AUTHOR]
- Subjects :
- NEURONS
ALZHEIMER'S disease
ASTROCYTES
MEDICAL botany
NEURODEGENERATION
CELL death
Subjects
Details
- Language :
- English
- ISSN :
- 13872877
- Volume :
- 99
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Alzheimer's Disease
- Publication Type :
- Academic Journal
- Accession number :
- 177228795
- Full Text :
- https://doi.org/10.3233/JAD-231387