48 results on '"Pascal Demoly"'
Search Results
2. Creating a French Dataset for artificial intelligence-assisted allergy diagnosis using semantic attributes and allergen multiplex technology
- Author
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Guillaume Martinroche, Julien Goret, Pol-André Apoil, Isabella Annesi-Maesano, Eric Fromentin, Laurent Guilleminault, Davide Caimmi, Caroline Klingebiel, Alain Didier, Joana Vitte, and Pascal Demoly
- Subjects
Immunology ,Immunology and Allergy - Published
- 2023
3. Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology
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Karin C. Lødrup Carlsen, L. Cecchi, F. Portejoie, T. Vontetsianos, Olivier Vandenplas, M. van Hague, D. Mora Bogado, M. Illario, Dana Wallace, L. Namazova-Baranova, E. Asayag, I. Ribeirinho, E. Costa, Shona Pedersen, Inger Kull, Davor Plavec, M. Morais-Almeida, Mickael Bewick, N.H. Chavannes, I. J. Ansotegui, G. De Carlo, K. S. Bennoor, Faradiba Sarquis Serpa, S. Arnavielle, F. Corti, Moises A. Calderon, Martín Bedolla-Barajas, Mette Sørensen, Isabella Annesi-Maesano, Elaine Colgan, Przemyslaw Kardas, M. van Eerd, Jorge Maspero, Valérie Siroux, Isabelle Momas, Ralph Mösges, Yves Dauvilliers, T. Keil, T. Bieber, Marit Westman, Rachel Nadif, O. Pfaar, A.C. Carvalho Coehlo, R. M. Cortés-Grimaldo, I. Skrindo, Piotr Kuna, Nicola Scichilone, Antonella Muraro, Kimihiro Okubo, Paulo Augusto Moreira Camargos, C. Cartier, Oliver Pfaar, K. Ohta, Barbara P. Yawn, Igor Kaidashev, Michel Thibaudon, X. Basagana, I. Kaidashev, Bilun Gemicioglu, S. Genova, Hae-Sim Park, J.J. Matta Campos, Simon Walker, Ulf Darsow, Fulvio Braido, J. Salimäki, T. Zuberbier, Raphaël Chiron, Mohammad Reza Masjedi, G.D. Marshall, Branislava Milenkovic, W. J. Fokkens, Eric D. Bateman, Robert M. Naclerio, Steve Montefort, M. de Fátima Emerson, T. Werfel, Cemal Cingi, A. Szylling, Martin Wagenmann, I. Baiardini, L. T. T. Le, N. Khaltaev, Ki-Suck Jung, Agnieszka Lipiec, Panayiotis K. Yiallouros, A Valero, R. Gerth van Wijk, L. Hernández, Marek L. Kowalski, C. Zubrinich, Sinthia Bosnic-Anticevich, Miguel A. Sierra, Erik Melén, T. Haahtela, Rute Almeida, Violeta Kvedariene, R. Pawankar, T.A. Popov, Flore Amat, Sanna Toppila-Salmi, M. Gotua, A. Sheikh, A. Bedbrook, Torsten Zuberbier, B. De Martino, Gérard Dray, Francesca Avolio, E. Mandajieva, B. Samolinski, Petr Panzner, P. Kuna, Philippe-Jean Bousquet, T. D. Nyembue, Luo Zhang, Leyla Namazova-Baranova, Ana Maria Carriazo, João Fonseca, E. Van Ganse, Roland Buhl, M. Bochenska Marciniak, Cristiana Stellato, J. da Silva, J. E. Gereda, Han-Jung Park, M.C. Costa-Dominguez, W. Carr, Dirceu Solé, S. Forti, Nanshan Zhong, Jordi Sunyer, Alain Didier, Y. Z. Chen, Thomas B. Casale, Jim Phillips, Isabelle Bosse, Manuel Teixeira Veríssimo, D. Y. Wang, U. Trama, Cristina Bárbara, David Somekh, T. Camuzat, R. N. Naclerio, Enrico Novellino, Leszek Klimek, M. Rodriguez Gonzalez, Holger J. Schünemann, Mario Barbagallo, D. Larenas-Linnemann, Mario Sánchez-Borges, Massimo Triggiani, Y. Okamoto, E. Mathieu-Dupas, N. Di Carluccio, S. Toppila-Salmi, Omer Kalayci, Rudolf Valenta, J. Coll, F. de Blay, Wienczyslawa Czarlewski, W. Pohl, Piotr Wroczyński, Kian Fan Chung, Nikolaos G. Papadopoulos, Pascal Demoly, Hubert Blain, M. Crescenzo, O. Kalayci, Leocadio Rodríguez-Mañas, G. Moda, L. Cox, Z. Gutter, A. Mair, Andrew Bush, Maria-Dolores Mogica-Martinez, Giorgio Walter Canonica, Antonio Valero, Daniel Laune, A. Zurkuhlen, Paul C. Potter, D. Wallace, Gabrielle L. Onorato, Mihaela Zidarn, E.P. Prokopakis, Anne Lise Courbis, Sergio Bonini, Ruta Dubakiene, A. Papi, Y. El-Gamal, Jacques Mercier, Wytske Fokkens, Rodolphe Bourret, S. Palkonen, A. Yorgancioglu, G. Vezzani, J. A. Rizzo, D. Plavec, D. Caillot, G. De Feo, E. Menditto, Caterina Bucca, A. C. Pozzi, Hironori Sagara, I. Grisle, I. Pin, Christopher E. Brightling, Ludger Klimek, F.F. Morato-Castro, Désirée Larenas-Linnemann, Alessandro Vatrella, A. A. Cruz, Guy Joos, E.D. Bateman, Erendira Rodriguez-Zagal, H. Douagui, T. To, Edgardo Jares, C. Bindslev-Jensen, G. Levato, J. O. B. Hourihane, R. Rajabian-Soderlund, C. Odzhakova, J. Bousquet, M. T. Ventura, Arzu Yorgancioglu, Osman M. Yusuf, H. J. Zar, Giovanni Rolla, Sebastian L. Johnston, M.S. Dykewicz, Esben Eller, A. Gamkrelidze, Filip Raciborski, Renzo Angles, Rafael Stelmach, M. Nogues, David Price, Mário Morais-Almeida, Tari Haahtela, Teresa To, D. Conforti, Stephen R. Durham, S. Gonzalez Diaz, V. Cardona, Werner Aberer, B. Milenkovic, Luigi Napoli, K. C. Bergmann, P W Hellings, M. Lessa, P. Panzner, Alfonso M. Cepeda Sarabia, M. Guidacci, A.L. Matos, Todor A. Popov, C. Suppli Ulrik, Diana Deleanu, N. de Paula Motta Rubini, Carsten Bindslev-Jensen, I. Majer, Ioana Agache, B. A. Barreto, R. Picard, Erkka Valovirta, A. Fink-Wagner, L. Colas, João O. Malva, Thomas Keil, M. T. Burguete Cabañas, Bolesław Samoliński, M.H. Garcia-Cruz, L.P. Boulet, K. Nekam, Edyta Krzych-Fałta, P. Devillier, J. Ferreira de Mello, Jussi Karjalainen, I. Bogus-Buczynska, Susan Waserman, Marcus Maurer, Tomas Chivato, Elena Bacci, M. Przemecka, Olga Lourenço, José Miguel Fuentes-Pérez, M. Zidarn, Talant Sooronbaev, J.M. Anto, W. Czarlewski, R. Murray, Luís Nogueira-Silva, G. Passalacqua, E. Chkhartishvili, Oscar Mayora, Victoria Cardona, M. Sondermann, Piotr Lacwik, S. Ouedraogo, I. Baroni, Artur Z. Białoszewski, G Scadding, J. Strozek, R. Emuzyte, Neven Miculinic, Ruby Pawankar, Ken Ohta, I. Agache, J.L. Gálvez-Romero, Nikos G. Papadopoulos, E. O. Meltzer, I. Annesi-Maesano, E. De Manuel Keenoy, Jorge A. Luna-Pech, Ana Margarida Pereira, Paul Potter, M. Ortega Cisneros, J. Li, K. F. Rabe, M. Rottem, Mikael Benson, Ali Fuat Kalyoncu, Dermot Ryan, Dieter Maier, C.Y. García-Cobas, S. Bialek, G. Du Toit, S. Shamai, S. Mavale-Manuel, Rojin Rajabian-Soderlund, Maddalena Illario, Philippe Devillier, F. Rodenas, Emmanuel P. Prokopakis, De Yun Wang, Niels H. Chavannes, E.H.D. Bel, Bianca Beghe, Sietze Reitsma, John Wright, O. Lourenço, L.T.T. Le, Josep M. Antó, T. Casale, Paul K. Keith, K. C. Lødrup Carlsen, P. Demoly, Mikael Kuitunen, Marc Humbert, A. M. Cepeda Sarabia, Ignacio J. Ansotegui, M.C. Rizzo, Davide Caimmi, Milan Sova, Nick A. Guldemond, P. Yakovliev, Judah A. Denburg, Jaime Correia de Sousa, Elisabete Melo-Gomes, Aziz Sheikh, I. Bosse, M. M. Ciaravolo, S. Di Capua Ercolano, Alpana Mair, P. Lieberman, Isabella Pali-Schöll, Leif Bjermer, G. De Vries, M. Roman Rodriguez, Johanna Salimäki, Carmen Panaitescu, F. Mihaltan, Giulia De Feo, F. E. R. Simons, A. Blua, B. Mahboub, D. Ryan, M. Bewick, Anabela Mota-Pinto, J.A. Fonseca, Neil Wilson, Marek Jutel, Dennis M. Williams, M. Akdis, Menachem Rottem, Marcello Persico, J. C. Ivancevich, Nelson Rosario, A. Farsi, Alvaro A. Cruz, Liguo Zhang, Anna Bedbrook, L. Bertorello, Magnus Wickman, Marilyn Urrutia-Pereira, O. Spranger, René Maximiliano Gómez, C. Bachert, Renaud Louis, Musa Khaitov, C. Stellato, Constantinos Pitsios, Roland Buonaiuto, A. Romano, Sîan A Williams, R. Puy, Daniela Rivero-Yeverino, Y. Mohammad, J. Farrell, Jan Brozek, Ricardo Pio Monti, E. Paulino, J. Correia de Sousa, Miguel Alejandro Medina-Ávalos, Jocelyne Just, Peter Valentin Tomazic, Jean-François Ferrero, Antoine Magnan, S. Waserman, J Rosado-Pinto, Maciek Kupczyk, C.S. Bosnic-Anticevich, T. Dedeu, Tommi Vasankari, R. Mösges, Robin O'Hehir, Ema Paulino, Peter Hellings, A. Neou, M. Wickman, D. Lauri, Jean Bousquet, A. Ciceran, Jacques Bouchard, Yehia El-Gamal, M.G. Dominguez-Silva, M.R. Alberti, Jean-Louis Pépin, Kimi Okubo, Juan Carlos Ivancevich, Patrik Eklund, Benoit Pugin, C. Dario, Mussa Khaitov, Luisa Brussino, A.G. Chuchalin, Elísio Costa, Susanna Palkonen, Lars Münter, Pedro Carreiro-Martins, R.E. Pulido Ross, Ettore Novellino, Kai-Håkon Carlsen, María Antonieta Guzmán, G.W. Canonica, Gabriel Onorato, Giuseppe De Carlo, R.E. Roller-Wirnsberger, Brian J. Lipworth, M. A. Guzman, J.N. Tebyriçá, Adnan Custovic, Yoshitaka Okamoto, Rimantas Stukas, P. Manning, J. Sastre-Dominguez, Caroline L.S. George, Robyn E O'Hehir, K. Maciej, Bassam Mahboub, J. F. Fontaine, Arũnas Valiulis, Xavier Rodó, D. Vicheva, G. Canfora, Vitalis Briedis, S. Rodrigues Valle, Mark S. Dykewicz, Joanne Rimmer, G. Castellano, B. Pigearias, A. L. Boner, Yunuen Rocío Huerta-Villalobos, Christine Rolland, H. Neffen, H. Arshad, Javier Gómez-Vera, P. Moura Santo, Frederic Viart, F. Blasi, J. Garcia-Aymerich, Lorenzo Cecchi, V. Niedeberger, Giorgio Ciprandi, F. Caballero-Fonseca, Jean-François Fontaine, J Mullol, Maurizio Romano, M. Viegi, Mario E. Zernotti, Arunas Valiulis, Anna Asarnoj, Antonio Nieto, J. Lavrut, D. Dokic, V. Kvedariene, Ewa Jassem, Cezmi A. Akdis, Ruth Murray, Claus Bachert, Peter Schmid-Grendelmeier, Emilie Burte, Joaquim Mullol, Guido Iaccarino, J. Kleine-Tebbe, P. V. Tomazic, E. Eller, Alessandro Fiocchi, H.J. Schunemann, M. Sorlini, C. Robalo-Cordeiro, Ana-Maria Todo-Bom, J. Brozek, Marco Nalin, Matteo Bonini, J. C. Sisul, S.E. Dahlen, F. Amat, Juan Carlos Sisul, Jawad Hajjam, Ana Todo-Bom, Enrica Menditto, Bousquet J., Hellings P.W., Agache I., Amat F., Annesi-Maesano I., Ansotegui I.J., Anto J.M., Bachert C., Bateman E.D., Bedbrook A., Bennoor K., Bewick M., Bindslev-Jensen C., Bosnic-Anticevich S., Bosse I., Brozek J., Brussino L., Canonica G.W., Cardona V., Casale T., Cepeda Sarabia A.M., Chavannes N.H., Cecchi L., Correia de Sousa J., Costa E., Cruz A.A., Czarlewski W., De Carlo G., De Feo G., Demoly P., Devillier P., Dykewicz M.S., El-Gamal Y., Eller E.E., Fonseca J.A., Fontaine J.-F., Fokkens W.J., Guzman M.-A., Haahtela T., Illario M., Ivancevich J.-C., Just J., Kaidashev I., Khaitov M., Kalayci O., Keil T., Klimek L., Kowalski M.L., Kuna P., Kvedariene V., Larenas-Linnemann D., Laune D., Le L.T.T., Carlsen K.L., Lourenco O., Mahboub B., Mair A., Menditto E., Milenkovic B., Morais-Almeida M., Mosges R., Mullol J., Murray R., Naclerio R., Namazova-Baranova L., Novellino E., O'Hehir R.E., Ohta K., Okamoto Y., Okubo K., Onorato G.L., Palkonen S., Panzner P., Papadopoulos N.G., Park H.-S., Paulino E., Pawankar R., Pfaar O., Plavec D., Popov T.A., Potter P., Prokopakis E.P., Rottem M., Ryan D., Salimaki J., Samolinski B., Sanchez-Borges M., Schunemann H.J., Sheikh A., Sisul J.-C., Rajabian-Soderlund R., Sooronbaev T., Stellato C., To T., Todo-Bom A.-M., Tomazic P.-V., Toppila-Salmi S., Valero A., Valiulis A., Valovirta E., Ventura M.-T., Wagenmann M., Wang D.Y., Wallace D., Waserman S., Wickman M., Yorgancioglu A., Zhang L., Zhong N., Zidarn M., Zuberbier T., Aberer W., Akdis C.A., Akdis M., Alberti M.R., Almeida R., Angles R., Arnavielle S., Asayag E., Asarnoj A., Arshad H., Avolio F., Bacci E., Baiardini I., Barbara C., Barbagallo M., Baroni I., Barreto B.A., Basagana X., Bedolla-Barajas M., Beghe B., Bel E.H., Bergmann K.C., Benson M., Bertorello L., Bialoszewski A.Z., Bieber T., Bialek S., Bjermer L., Blain H., Blasi F., Blua A., Bochenska Marciniak M., Bogus-Buczynska I., Boner A.L., Bonini M., Bonini S., Bouchard J., Boulet L.P., Bourret R., Braido F., Briedis V., Brightling C.E., Bucca C., Buhl R., Buonaiuto R., Panaitescu C., Burguete Cabanas M.T., Burte E., Bush A., Caballero-Fonseca F., Caillot D., Caimmi D., Calderon M.A., Camargos P.A.M., Camuzat T., Canfora G., Carreiro-Martins P., Carriazo A.M., Carr W., Cartier C., Castellano G., Chen Y., Chiron R., Chivato T., Chkhartishvili E., Chuchalin A.G., Chung K.F., Ciaravolo M.M., Ciceran A., Cingi C., Ciprandi G., Carvalho Coehlo A.C., Colas L., Colgan E., Coll J., Conforti D., Cortes-Grimaldo R.M., Corti F., Costa-Dominguez M.C., Courbis A.L., Cox L., Crescenzo M., Custovic A., Dahlen S.E., Dario C., da Silva J., Dauvilliers Y., Darsow U., De Blay F., Dedeu T., de Fatima Emerson M., De Vries G., De Martino B., de Paula Motta Rubini N., Deleanu D., Denburg J.A., Di Capua Ercolano S., Di Carluccio N., Didier A., Dokic D., Dominguez-Silva M.G., Douagui H., Dray G., Dubakiene R., Durham S.R., Du Toit G., Eklund P., Emuzyte R., Farrell J., Farsi A., Ferreira de Mello J., Ferrero J., Fink-Wagner A., Fiocchi A., Forti S., Fuentes-Perez J.M., Galvez-Romero J.L., Gamkrelidze A., Garcia-Aymerich J., Garcia-Cobas C.Y., Garcia-Cruz M.H., Gemicioglu B., Genova S., George C., Gereda J.E., Gerth van Wijk R., Gomez R.M., Gomez-Vera J., Gonzalez Diaz S., Gotua M., Grisle I., Guidacci M., Guldemond N.A., Gutter Z., Hajjam J., Hernandez L., Hourihane J.O., Huerta-Villalobos Y.R., Humbert M., Iaccarino G., Jares E.J., Jassem E., Johnston S.L., Joos G., Jung K.S., Jutel M., Kalyoncu A.F., Karjalainen J., Kardas P., Keith P.K., Khaltaev N., Kleine-Tebbe J., Kuitunen M., Kull I., Kupczyk M., Krzych-Falta E., Lacwik P., Lauri D., Lavrut J., Lessa M., Levato G., Li J., Lieberman P., Lipiec A., Lipworth B., Lodrup Carlsen K.C., Louis R., Luna-Pech J.A., Maciej K., Magnan A., Maier D., Majer I., Malva J., Mandajieva E., Manning P., De Manuel Keenoy E., Marshall G.D., Masjedi M.R., Maspero J.F., Mathieu-Dupas E., Matta Campos J.J., Matos A.L., Maurer M., Mavale-Manuel S., Mayora O., Medina-Avalos M.A., Melen E., Melo-Gomes E., Meltzer E.O., Mercier J., Miculinic N., Mihaltan F., Moda G., Mogica-Martinez M.D., Mohammad Y., Momas I., Montefort S., Monti R., Mora Bogado D., Morato-Castro F.F., Mota-Pinto A., Moura Santo P., Munter L., Muraro A., Nadif R., Nalin M., Napoli L., Neffen H., Niedeberger V., Nekam K., Neou A., Nieto A., Nogueira-Silva L., Nogues M., Nyembue T.D., Odzhakova C., Ortega Cisneros M., Ouedraogo S., Pali-Scholl I., Papi A., Passalacqua G., Pedersen S., Pepin J.L., Pereira A.M., Persico M., Phillips J., Picard R., Pigearias B., Pin I., Pitsios C., Pohl W., Portejoie F., Pozzi A.C., Price D., Puy R., Pugin B., Pulido Ross R.E., Przemecka M., Rabe K.F., Raciborski F., Reitsma S., Ribeirinho I., Rimmer J., Rivero-Yeverino D., Rizzo J.A., Rizzo M.C., Robalo-Cordeiro C., Rodenas F., Rodo X., Rodriguez Gonzalez M., Rodriguez-Manas L., Rolland C., Rodrigues Valle S., Roman Rodriguez M., Romano A., Rodriguez-Zagal E., Rolla G., Roller-Wirnsberger R.E., Romano M., Rosado-Pinto J., Rosario N., Sagara H., Sastre-Dominguez J., Scadding G.K., Scichilone N., Schmid-Grendelmeier P., Serpa F.S., Shamai S., Sierra M., Simons F.E.R., Siroux V., Skrindo I., Sole D., Somekh D., Sondermann M., Sova M., Sorensen M., Sorlini M., Spranger O., Stelmach R., Stukas R., Sunyer J., Strozek J., Szylling A., Tebyrica J.N., Thibaudon M., Trama U., Triggiani M., Suppli Ulrik C., Urrutia-Pereira M., Valenta R., van Eerd M., van Ganse E., van Hague M., Vandenplas O., Vezzani G., Vasankari T., Vatrella A., Verissimo M.T., Viart F., Viegi M., Vicheva D., Vontetsianos T., Walker S., Werfel T., Westman M., Williams D.M., Williams S., Wilson N., Wright J., Wroczynski P., Yakovliev P., Yawn B.P., Yiallouros P.K., Yusuf O.M., Zar H.J., Zernotti M.E., Zubrinich C., Zurkuhlen A., Bousquet, Jean, Hellings, Peter W., Agache, Ioana, Amat, Flore, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Clau, Bateman, Eric D., Bedbrook, Anna, Bennoor, Kazi, Bewick, Mickael, Bindslev-Jensen, Carsten, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Brozek, Jan, Brussino, Luisa, Canonica, Giorgio W., Cardona, Victoria, Casale, Thoma, Cepeda Sarabia, Alfonso M., Chavannes, Niels H., Cecchi, Lorenzo, Correia de Sousa, Jaime, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, De Carlo, Giuseppe, De Feo, Giulia, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S., El-Gamal, Yehia, Eller, Esben E., Fonseca, Joao A., Fontaine, Jean-Françoi, Fokkens, Wytske J., Guzmán, Maria-Antonieta, Haahtela, Tari, Illario, Maddalena, Ivancevich, Juan-Carlo, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Kalayci, Omer, Keil, Thoma, Klimek, Ludger, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Desiree, Laune, Daniel, Le, Lan T. T., Carlsen, Karin Lodrup, Lourenço, Olga, Mahboub, Bassam, Mair, Alpana, Menditto, Enrica, Milenkovic, Branislava, Morais-Almeida, Mario, Mösges, Ralph, Mullol, Joaquim, Murray, Ruth, Naclerio, Robert, Namazova-Baranova, Leyla, Novellino, Ettore, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kimi, Onorato, Gabrielle L., Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikos G., Park, Hae-Sim, Paulino, Ema, Pawankar, Ruby, Pfaar, Oliver, Plavec, Davor, Popov, Ted A., Potter, Paul, Prokopakis, Emmanuel P., Rottem, Menachem, Ryan, Dermot, Salimäki, Johanna, Samolinski, Boleslaw, Sanchez-Borges, Mario, Schunemann, Holger J., Sheikh, Aziz, Sisul, Juan-Carlo, Rajabian-Söderlund, Rojin, Sooronbaev, Talant, Stellato, Cristiana, To, Teresa, Todo-Bom, Ana-Maria, Tomazic, Peter-Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Aruna, Valovirta, Erkka, Ventura, Maria-Teresa, Wagenmann, Martin, Wang, De Yun, Wallace, Dana, Waserman, Susan, Wickman, Magnu, Yorgancioglu, Arzu, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Zuberbier, Torsten, Bousquet, J., Hellings, P. W., Aberer, W., Agache, I., Akdis, C. A., Akdis, M., Alberti, M. R., Almeida, R., Amat, F., Angles, R., Annesi-Maesano, I., Ansotegui, I. J., Anto, J. M., Arnavielle, S., Asayag, E., Asarnoj, A., Arshad, H., Avolio, F., Bacci, E., Bachert, C., Baiardini, I., Barbara, C., Barbagallo, M., Baroni, I., Barreto, B. A., Basagana, X., Bateman, E. D., Bedolla-Barajas, M., Bedbrook, A., Bewick, M., Beghé, B., Bel, E. H., Bergmann, K. C., Bennoor, K. S., Benson, M., Bertorello, L., Białoszewski, A. Z., Bieber, T., Bialek, S., Bindslev-Jensen, C., Bjermer, L., Blain, H., Blasi, F., Blua, A., Bochenska Marciniak, M., Bogus-Buczynska, I., Boner, A. L., Bonini, M., Bonini, S., Bosnic-Anticevich, C. S., Bosse, I., Bouchard, J., Boulet, L. P., Bourret, R., Bousquet, P. J., Braido, F., Briedis, V., Brightling, C. E., Brozek, J., Bucca, C., Buhl, R., Buonaiuto, R., Panaitescu, C., Burguete Cabañas, M. T., Burte, E., Bush, A., Caballero-Fonseca, F., Caillot, D., Caimmi, D., Calderon, M. A., Camargos, P. A. M., Camuzat, T., Canfora, G., Canonica, G. W., Cardona, V., Carlsen, K. H., Carreiro-Martins, P., Carriazo, A. M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda Sarabia, A. M., Chavannes, N. H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciaravolo, M. M., Ciceran, A., Cingi, C., Ciprandi, G., Carvalho Coehlo, A. C., Colas, L., Colgan, E., Coll, J., Conforti, D., Correia de Sousa, J., Cortés-Grimaldo, R. M., Corti, F., Costa, E., Costa-Dominguez, M. C., Courbis, A. L., Cox, L., Crescenzo, M., Cruz, A. A., Custovic, A., Czarlewski, W., Dahlen, S. E., Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., de Fátima Emerson, M., De Feo, G., De Vries, G., De Martino, B., de Paula Motta Rubini, N., Deleanu, D., Demoly, P., Denburg, J. A., Devillier, P., Di Capua Ercolano, S., Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M. G., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., El-Gamal, Y., Eklund, P., Eller, E., Emuzyte, R., Farrell, J., Farsi, A., Ferreira de Mello, J., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fokkens, W. J., Fonseca, J. A., Fontaine, J. F., Forti, S., Fuentes-Perez, J. M., Gálvez-Romero, J. L., Gamkrelidze, A., Garcia-Aymerich, J., García-Cobas, C. Y., Garcia-Cruz, M. H., Gemicioğlu, B., Genova, S., George, C., Gereda, J. E., Gerth van Wijk, R., Gomez, R. M., Gómez-Vera, J., González Diaz, S., Gotua, M., Grisle, I., Guidacci, M., Guldemond, N. A., Gutter, Z., Guzmán, M. A., Haahtela, T., Hajjam, J., Hernández, L., Hourihane, J. O. 'B., Huerta-Villalobos, Y. R., Humbert, M., Iaccarino, G., Illario, M., Ivancevich, J. C., Jares, E. J., Jassem, E., Johnston, S. L., Joos, G., Jung, K. S., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Kardas, P., Keil, T., Keith, P. K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., Kowalski, M. L., Kuitunen, M., Kull, I., Kuna, P., Kupczyk, M., Kvedariene, V., Krzych-Fałta, E., Lacwik, P., Larenas-Linnemann, D., Laune, D., Lauri, D., Lavrut, J., Le, L. T. T., Lessa, M., Levato, G., Li, J., Lieberman, P., Lipiec, A., Lipworth, B., Lodrup Carlsen, K. C., Louis, R., Lourenço, O., Luna-Pech, J. A., Maciej, K., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., De Manuel Keenoy, E., Marshall, G. D., Masjedi, M. R., Maspero, J. F., Mathieu-Dupas, E., Matta Campos, J. J., Matos, A. L., Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M. A., Melén, E., Melo-Gomes, E., Meltzer, E. O., Menditto, E., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M. D., Mohammad, Y., Momas, I., Montefort, S., Monti, R., Mora Bogado, D., Morais-Almeida, M., Morato-Castro, F. F., Mösges, R., Mota-Pinto, A., Moura Santo, P., Mullol, J., Münter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, T. D., O'Hehir, R. E., Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G. L., Ortega Cisneros, M., Ouedraogo, S., Pali-Schöll, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Park, H. S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pépin, J. L., Pereira, A. M., Persico, M., Pfaar, O., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Pozzi, A. C., Price, D., Prokopakis, E. P., Puy, R., Pugin, B., Pulido Ross, R. E., Przemecka, M., Rabe, K. F., Raciborski, F., Rajabian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Rivero-Yeverino, D., Rizzo, J. A., Rizzo, M. C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Rodriguez Gonzalez, M., Rodriguez-Mañas, L., Rolland, C., Rodrigues Valle, S., Roman Rodriguez, M., Romano, A., Rodriguez-Zagal, E., Rolla, G., Roller-Wirnsberger, R. E., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Sagara, H., Salimäki, J., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schunemann, H. J., Scichilone, N., Schmid-Grendelmeier, P., Serpa, F. S., Shamai, S., Sheikh, A., Sierra, M., Simons, F. E. R., Siroux, V., Sisul, J. C., Skrindo, I., Solé, D., Somekh, D., Sondermann, M., Sooronbaev, T., Sova, M., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyriçá, J. N., Thibaudon, M., To, T., Todo-Bom, A., Tomazic, P. V., Toppila-Salmi, S., Trama, U., Triggiani, M., Suppli Ulrik, C., Urrutia-Pereira, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., van Eerd, M., van Ganse, E., van Hague, M., Vandenplas, O., Ventura, M. T., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M. T., Viart, F., Viegi, M., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B. P., Yiallouros, P. K., Yorgancioglu, A., Yusuf, O. M., Zar, H. J., Zhang, L., Zhong, N., Zernotti, M. E., Zidarn, M., Zuberbier, T., Zubrinich, C., Zurkuhlen, A., CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Laboratory of clinical immunology, Department of Allergy and Clinical Immunology, Transylvania University of Brasov, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Epidémiologie, Systèmes d'Information, Modélisation, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Department of Allergy and Immunology, Hospital Quirónsalud Bizkaia [Bilbao], Center for Research in Environmental Epidemiology (CREAL), Universitat Pompeu Fabra [Barcelona] (UPF)-Catalunya ministerio de salud, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hacettepe University = Hacettepe Üniversitesi, Mechanobiology Institute [Singapore] (MBI), National University of Singapore (NUS), Department of Clinical Epidemiology and Biostatistics and Medicine, McMaster University [Hamilton, Ontario], Department of Dermatology [Graz, Austria], Medical University Graz, Swiss Institute of Allergy and Asthma Research (SIAF), Universität Zürich [Zürich] = University of Zurich (UZH), Department Engineering Quimica (ICEMS), Ghent University Hospital, Istituto Nazionale di Fisica Nucleare, sezione di Bari (INFN, sezione di Bari), Istituto Nazionale di Fisica Nucleare (INFN), IMIM-Hospital del Mar, Generalitat de Catalunya, University of Cape Town, Divisions of Human Genetics Infection, Inflammation and Repair, University of Southampton-School of Medicine, Centre de gérontologie, Department of Pathophysiology and Transplantation, Università degli Studi di Milano = University of Milan (UNIMI), Istituto di Geoscienze e Georisorse, Pavia, Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II = Università degli studi di Napoli Federico II, Woolcock Institute of Medical Research [Sydney], The University of Sydney, Université Laval [Québec] (ULaval), Departments of Clinical Epidemiology and Biostatistics and Medicine [Ontario], Service greffe de moelle osseuse, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Royal Brompton Hospital, Région Languedoc-Roussillon-Midi-Pyrénées, Vall d'Hebron University Hospital [Barcelona], University of South Florida [Tampa] (USF), Università degli Studi di Firenze = University of Florence (UniFI), University of Michigan, Department of Atmospheric, Centres de Ressources et de Compétences de la Mucoviscidose [Montpellier] (CRCM [Montpellier]), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve-Service des Maladies Respiratoires, Russian State Medical University, Universidade do Porto, Instituto de Biologia Molecular e Celular (IBMC), UCB Pharma, Colombes, Hôpital Gui de Chauliac [CHU Montpellier], CHU Strasbourg, European Federation of Allergy (EFA), Airways Diseases Patients' Associations, Università degli Studi di Salerno = University of Salerno (UNISA), Laboratoire de recherche sur les mécanismes moléculaires et pharmacologiques de l’obstruction bronchique (LOBIP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Laboratoire de Génie Informatique et Ingénierie de Production (LGI2P), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Linköping University (LIU), Department of Dermatology and Allergy Centre, Odense University Hospital, Vilnius University [Vilnius], Center of Research in Health Technologies and Information Systems (CINTESIS), Universidade do Porto = University of Porto, Institut d'Electronique du Solide et des Systèmes (InESS), Centre National de la Recherche Scientifique (CNRS), Son Pisa Primary Care Centre, IB-Salut Balearic Health Service, Center for Allergy and Immunology Research [Tbilisi], Department of Dermatology, Helsinki University Hospital-Skin and Allergy Hospital, Swedish Meteorological and Hydrological Institute (SMHI), CORYSS-TESS, Ukrainina Medical Stomatological Academy [Poltava, Ukraine], Institute of Social Medicine, Epidemiology and Health Economics-Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Biologie des organismes marins et écosystèmes (BOME), Muséum national d'Histoire naturelle (MNHN)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), NRC Institute of immunology FMBA, Moscow Russian federation, Allergy and Asthma Center Westend, German Society for Otorhinolaryngology HNS, Rheinische Friedrich-Wilhelms-Universität Bonn, The Institute of Environmental Medicine [Stockholm] (IMM), Karolinska Institutet [Stockholm], Medical University of Łódź (MUL), Hospital Medica Sur, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Applied Physical Chemistry Laboratory (APCLab), Institute of Geophysics and Planetary Physics [Los Angeles] (IGPP), University of California [Los Angeles] (UCLA), University of California (UC)-University of California (UC), Équipe de Recherche en Textes, Informatique, Multilinguisme (ERTIM), Institut National des Langues et Civilisations Orientales (Inalco), Institute of Oceanology [China], University of Beira Interior [Portugal] (UBI), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Pulmonary and allergy unit, American University of Sharjah-Rashid Hospital-Dubai Health Authority (DHA), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Sysdiag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic (SysDiag ), BIO-RAD-Centre National de la Recherche Scientifique (CNRS), 'Federico II' University of Naples Medical School, Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Pneumology Department, Marius Nasta Institute of Pneumology, Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw - Poland-Faculté de Pharmacie de Paris, Allergy and Clinical Immunology Department, Hospital CUF Descobertas, Universität zu Köln = University of Cologne, Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Section of Otolaryngology-Head & Neck Surgery (OHNS), University of Chicago, Department of Pharmacy Naples, Université de Naples, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital-Monash University Building, AMREP, Dept. of Electronic Engineering, Chubu University, Department of Otorhinolaryngology, Chiba University Hospital, Department of Allergology and Clinical Immunology, Charles University [Prague] (CU)-Medical Faculty in Pilsen, Department of Earth and Planetary Sciences [Cambridge, USA] (EPS), Harvard University, Allergy and Respiratory Diseases, Università degli studi di Genova = University of Genoa (UniGe), Department of Pediatrics, Nippon Medical School, Centre Hospitalier Universitaire [Grenoble] (CHU), Department of Otorhinolaryngology, Head and Neck Surgery [Mannheim, Germany], University Hospital Mannheim, Laboratoire de physique et chimie des nano-objets (LPCNO), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), CHU Grenoble, Children’s Hospital Srebrnjak [Zagreb, Croatia], Department of Physics [UMIST Manchester], University of Manchester Institute of Science and Technology (UMIST), Laboratori Nazionali del Sud (LNS), Getafe University Hospital, Madrid, Karl-Franzens-Universität Graz, Ecologie comportementale (EC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes (UR)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Allergy Asthma and Immunology [Haifa, Israel], Ha'Emek Medical Center, Afula-Rappaport Faculty of Medicine, University of Edinburgh, Medical University of Warsaw - Poland, Department of Allergy and Clinical Immunology [Caracas, Venezuela], Centro Médico Docente La Trinidad, Department of Computer Science [Haifa], University of Haifa [Haifa], Allergy and Respiratory Research Group, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), National Centre of Cardiology and Internal Medicine, Ministry of Health Kyrgyz Republic, Réseau National de Surveillance Aérobiologique (RNSA), Berkeley Seismological Laboratory, Division of Clinical Immunology and Allergy, University of Naples Federico II = Università degli studi di Napoli Federico II, CIRCE, Ctr Res Energy Resources & Consumpt, Zaragoza 50018, Spain, Vilnius University Clinic of Children's Diseases, Suomen Terveystalo Allergy Clinic, Health Service and Performance Research (HESPER), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Centre d'EPistémologie et d'ERgologie Comparatives (CEPERC), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institute for Climate and Atmospheric Science [Leeds] (ICAS), School of Earth and Environment [Leeds] (SEE), University of Leeds-University of Leeds, Nova Southeastern University (NSU), Department of Otolaryngology, National University of Singapore (NUS)-Yong Loo Lin School of Medicine, Sachs' Children's Hospital, IAES, Department of Pulmonology, Manisa Celal Bayar University, Center for Evolutionary and Theoretical Immunology [Albuquerque, New Mexico] (CETI), The University of New Mexico [Albuquerque], National Key State Laboratory for ThermoStructural Composites (TSCM), Northwestern Polytechnical University [Xi'an] (NPU), Respiratory and Allergic Diseases, University Clinic of Respiratory and Allergic Diseases Golnik, University Hospital of Cologne [Cologne], Supported by the European Innovation Partnership on Active and Healthy Ageing and POLLAR (EIT Health, European Union)., European Project: 643803,H2020,H2020-HCO-2014,PROEIPAHA(2015), UCL - (MGD) Service de pneumologie, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidemiology of Allergic and Respiratory Diseases Department [Paris] (EPAR), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospital Quiròn Bizkaia Erandio, Université Pierre et Marie Curie - Paris 6 (UPMC), University of Milan, University of Naples Federico II-CNR, Rome, Italy and Department of Medicine, Université Paris Diderot - Paris 7 (UPD7)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Hôpital Gui de Chauliac, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Università degli Studi di Salerno (UNISA), Institut de Physique du Globe de Paris (IPGP), Centre National de la Recherche Scientifique (CNRS)-Université de La Réunion (UR)-Université Paris Diderot - Paris 7 (UPD7)-IPG PARIS-Institut national des sciences de l'Univers (INSU - CNRS), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]-Epidemiology and Health Economics, Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN), University of California-University of California, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hospital CUF-Descobertas, Universität zu Köln, Medical Faculty in Pilsen-Charles University in Prague - the First Faculty of Medicine, Harvard University [Cambridge], University of Genoa (UNIGE), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), University of Graz, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université Claude Bernard Lyon 1 (UCBL), Centro Medico-Docente La Trinidad, Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Università degli studi di Napoli Federico II, Center for Evolutionary and theoretical Immunology, Biology, National Institute for Health Research, CNR, Rome, Italy and Department of Medicine-University of Naples Federico II, Institut national des sciences de l'Univers (INSU - CNRS)-IPG PARIS-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Karl-Franzens-Universität [Graz, Autriche], Department of Dermatology, Allergology and Venereology, Clinicum, University of Helsinki, Children's Hospital, Faculty of Law, HUS Children and Adolescents, HUS Inflammation Center, University Hospitals Leuven [Leuven], Universitat Pompeu Fabra [Barcelona]-Catalunya ministerio de salud, University of Zürich [Zürich] (UZH), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), University of South Florida (USF), Università degli Studi di Firenze = University of Florence [Firenze], Laboratoire Magmas et Volcans (LMV), Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Universidade do Porto [Porto], Charité - Universitätsmedizin Berlin / Charite - University Medicine Berlin -Epidemiology and Health Economics, Université Pierre et Marie Curie - Paris 6 (UPMC)-Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Sondra, CentraleSupélec, Université Paris-Saclay (COmUE) (SONDRA), ONERA-CentraleSupélec-Université Paris Saclay (COmUE), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), RNSA, Centre d'EPistémologie et d'ERgologie Comparatives - UMR 7304 (CEPERC), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Ear, Nose and Throat, AII - Inflammatory diseases, Pulmonology, Institut de Recherche sur les Systèmes Atomiques et Moléculaires Complexes (IRSAMC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), National Institute for Nuclear Physics (INFN), Université Laval, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Università degli Studi di Firenze [Firenze], University of Salerno (UNISA), Centre National de la Recherche Scientifique (CNRS)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Observatoire de Physique du Globe de Clermont-Ferrand (OPGC), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Sondra, CentraleSupélec, Université Paris-Saclay (SONDRA), ONERA-CentraleSupélec-Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), École normale supérieure - Paris (ENS Paris)-Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université de Rennes 1 (UR1), Universidade do Minho, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, uBibliorum, and Internal Medicine
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Allergy ,Medicina Básica [Ciências Médicas] ,asthma -- guideline ,Allergic asthma ,DECISION-MAKING ,Allergic Rhinitis and Its Impact on Asthma ,GUIDELINES ,Medical and Health Sciences ,Medical Records ,0302 clinical medicine ,Health care ,Immunology and Allergy ,030212 general & internal medicine ,asthma ,Change management ,rhinitis ,Immunology ,MASK-RHINITIS ,ComputingMilieux_MISCELLANEOUS ,Rinitis ,mobilne aplikacije ,upravljanje sprememb ,Medical record ,GLOBAL STRATEGY ,WORK PRODUCTIVITY ,Telemedicine ,mobile applications ,3. Good health ,Asma alérgica ,rhiniti ,1107 Immunology ,Ciências Médicas::Medicina Básica ,klinične poti ,allergic -- guideline ,Life Sciences & Biomedicine ,Human ,PATIENT PARTICIPATION ,Allergic Rhinitis ,medicine.medical_specialty ,animal structures ,multimorbidity ,EUROPEAN INNOVATION PARTNERSHIP ,Change Management ,[object Object] ,Settore MED/10 - Malattie Dell'Apparato Respiratorio ,Asthma/diagnosis ,CHRONIC DISEASES ,MACVIA-ARIA ,03 medical and health sciences ,medicine ,multimorbidnost ,QUALITY ,Humans ,critical pathways ,astma -- smernica ,Patient participation ,Asma ,udc:616.2 ,Asthma ,Science & Technology ,ARIA ,business.industry ,Multimorbidity ,Rhinitis, Allergic ,Settore MED/09 - MEDICINA INTERNA ,change management ,Mobile Airways Sentinel Network (MASK) Study Group ,Guideline ,ta3121 ,medicine.disease ,Rinite alérgica ,Rhinitis, Allergic/diagnosis ,Integrated care ,alergijski rinitis -- smernica ,Allergic Rhinitis and Its Impact on Asthma, asthma, Change management, rhinitis, Immunology and Allergy, Immunology ,030228 respiratory system ,Family medicine ,3121 General medicine, internal medicine and other clinical medicine ,Medical Record ,Clinical Medicine ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Impact on Asthma - Abstract
Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional., EAACI -European Academy of Allergy and Clinical Immunology(undefined), info:eu-repo/semantics/acceptedVersion
- Published
- 2018
4. Methylene blue–treated plasma: An increased allergy risk?
- Author
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Pascal Demoly, A. Bazin, D. Laroche, Marie-Francoise Leconte Des Floris, Annick Alpérovitch, Jean-Yves Py, M. Carlier, Bernard Lamy, Danielle Rebibo, Christian Drouet, Jacques Bienvenu, A Lienhart, Béatrice Willaert, C. Caldani, and Paul-Michel Mertes
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Adult ,Aged, 80 and over ,Male ,Allergy ,business.industry ,Immunology ,Middle Aged ,Pharmacology ,medicine.disease ,Methylene Blue ,Plasma ,chemistry.chemical_compound ,chemistry ,Hypersensitivity ,Humans ,Immunology and Allergy ,Medicine ,Female ,business ,Methylene blue ,Aged - Published
- 2012
5. Multiple-allergen and single-allergen immunotherapy strategies in polysensitized patients: Looking at the published evidence
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Moises A. Calderon, Pascal Demoly, Philippe Moingeon, Linda Cox, and Thomas B. Casale
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Allergen immunotherapy ,Allergy ,medicine.medical_treatment ,Immunology ,Administration, Sublingual ,Administration, Cutaneous ,medicine.disease_cause ,Allergen ,Hypersensitivity ,otorhinolaryngologic diseases ,medicine ,Animals ,Humans ,Immunology and Allergy ,Sensitization ,Desensitization (medicine) ,House dust mite ,biology ,business.industry ,Immunotherapy ,Allergens ,biology.organism_classification ,medicine.disease ,respiratory tract diseases ,Clinical trial ,medicine.anatomical_structure ,Desensitization, Immunologic ,business - Abstract
In allergen immunotherapy there is debate as to whether polysensitized patients are best treated with many allergens simultaneously (chosen according to the sensitization profile, a predominantly North American approach) or a single allergen (chosen according to the most clinically problematic allergy, a predominantly European approach). In patients seeking treatment for moderate-to-severe respiratory allergies, polysensitization is more prevalent (range, 50% to 80%) than monosensitization in both the United States and Europe. Safe, effective, single-allergen preparations will most likely have been tested in polysensitized patients. In robust, large-scale clinical trials of grass pollen sublingual tablets, polysensitized patients benefited at least as much from allergen immunotherapy as monosensitized patients. A recent review of multiallergen immunotherapy concluded that simultaneous delivery of multiple unrelated allergens can be clinically effective but that there was a need for additional investigation of therapy with more than 2 allergen extracts (particularly in sublingual allergen immunotherapy). More work is also required to determine whether single-allergen and multiallergen immunotherapy protocols elicit distinct immune responses in monosensitized and polysensitized patients. Sublingual and subcutaneous multiallergen immunotherapy in polysensitized patients requires more supporting data to validate its efficacy in practice.
- Published
- 2012
6. Immunological Markers In House Dust Mite Allergic Subjects Treated With 300IR House Dust Mite Sublingual Tablets: Results From Two Phase III Trials
- Author
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Karl-Christian Bergmann, Yoshitaka Okamoto, Kathy Abiteboul, Kanchan Relwani, and Pascal Demoly
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House dust mite ,Phase iii trials ,biology ,business.industry ,Immunology ,Immunology and Allergy ,Medicine ,business ,biology.organism_classification - Published
- 2018
7. Efficacy of the SQ HDM SLIT-tablet on House Dust Mite Induced Allergic Conjunctivitis
- Author
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Pascal Demoly, David I. Bernstein, Harold S. Nelson, Hendrik Nolte, and Ida M. Smith
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House dust mite ,biology ,business.industry ,Immunology ,medicine ,Immunology and Allergy ,medicine.disease ,biology.organism_classification ,business ,Slit ,Allergic conjunctivitis - Published
- 2018
8. Anaphylaxis to dyes during the perioperative period: Reports of 14 clinical cases
- Author
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Abdelhaouad Benhaijoub, Jean Marc Malinovsky, Pascal Demoly, François Lavaud, Marie Caroline Bonnet-Boyer, Laurent Lalourcey, Paul-Michel Mertes, Philippe Pirat, Jocelyne Valfrey, James O’Brien, and Claudie Mouton-Faivre
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Adult ,Male ,medicine.medical_specialty ,Allergy ,Immunology ,Sentinel lymph node ,Perioperative Care ,law.invention ,law ,Biopsy ,Rosaniline Dyes ,medicine ,Humans ,Immunology and Allergy ,Outpatient clinic ,Coloring Agents ,Anaphylaxis ,Aged ,medicine.diagnostic_test ,business.industry ,Perioperative ,Middle Aged ,medicine.disease ,Intensive care unit ,Dermatology ,Surgery ,Epinephrine ,Female ,France ,business ,medicine.drug - Abstract
Background Vital dyes are widely used for lymphatic mapping and sentinel lymph node biopsy in patients with malignant tumors, and reports of anaphylactic reactions are becoming more frequent. Objective Our aims were to describe specific clinical features of hypersensitivity reactions to Patent Blue (Guerbet, Roissy, France), results of the allergy workup, and their consequences for patient management. Methods We report a series of 14 clinical cases of dye-induced anaphylaxis recorded between 2004 and 2006 in 4 member centers of a network of French allergoanesthesia outpatient clinics. Results Reactions appeared to be relatively severe (6/14 grade III reactions). An average 30 ± 6–minute delay was observed between dye injection and symptom onset. In 9 (65%) patients reactions were sustained for several hours, requiring prolonged continuous epinephrine infusion and transfer to an intensive care unit. Prick test results were positive in 8 patients. In 5 patients prick test results were negative, whereas intradermal test results were positive. Conclusion Anesthesiologists and allergologists must be aware of this specific risk and of the clinical characteristics of these reactions, which are usually delayed and long lasting.
- Published
- 2008
9. Mechanisms of the Development of Allergy (MeDALL) : Introducing novel concepts in allergy phenotypes
- Author
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Isabelle Pin, Stefano Guerra, Cynthia Hohmann, Marit Westman, Mariona Pinart, Jordi Mestres, Martijn C. Nawijn, Tari Haahtela, Dirkje S. Postma, Torsten Zuberbier, Kalus Wenzel, Mika J. Mäkelä, Fanny Rancière, Karin C. Lødrup Carlsen, Mirela Curin, Dieter Maier, Stephane Ballereau, Johan Pellet, Cezmi A. Akdis, Claus Bachert, Erik Melén, Emilie Burte, Bénédicte Jacquemin, Jean Bousquet, Anne Cambon-Thomsen, Christian Lupinek, I. Skrindo, Mübeccel Akdis, Rachel Nadif, Bert Brunekreef, Judith Garcia-Aymerich, Jonathan M. Coquet, Valérie Siroux, Inger Kull, Peter Mowinckel, Bart N. Lambrecht, Renata Kiss, Anna Bedbrook, Ferran Ballester, Kai-Håkon Carlsen, Yvan Saeys, Raphaëlle Varraso, Emmanuelle Rial-Sebbag, Giuseppe De Carlo, Sibylle Koletzko, Maria Pia Fantini, Joachim Heinrich, Jordi Sunyer, Andrea von Berg, Gerard H. Koppelman, Theresa Keller, Vergard Hovland, John Wright, Nicolas Lemonnier, Josep M. Antó, Marta Benet, Rudolf Valenta, Irina Lehmann, Susanne Lau, Francesco Forastiere, Isabelle Momas, Niklas Andersson, Albert Arno, Pascal Demoly, Jocelyne Just, Anna Bergström, Charles Auffray, Henriette A. Smit, Delphine Smagghe, Manolis Kogevinas, Anna Asarnoj, Marie Standl, Daniela Porta, I. Annesi-Maesano, Martijn J. Schuijs, Ulrike Gehring, Mathies Torrent, Thomas Keil, Christina Tischer, Cheng-Jian Xu, Esben Eller, Marek L. Kowalski, Carsten Bindslev-Jensen, Leda Chatzi, Magnus Wickman, Natalia Ballardini, Leena von Hertzen, Xavier Basagaña, Anto, Josep M., Bousquet, Jean, Akdis, Mubeccel, Auffray, Charle, Keil, Thoma, Momas, Isabelle, Postma, Dirkje S., Valenta, Rudolf, Wickman, Magnu, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N., Lodrup Carlsen, Karin C., Koppelman, Gerard H., Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L., Maier, Dieter, Melén, Erik, Smit, Henriette A., Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Nikla, Bachert, Clau, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M., Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manoli, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicola, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C., Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J., Siroux, Valerie, Tischer, Christina G., Torrent, Mathie, Varraso, Raphaelle, Wenzel, Kalu, Xu, Cheng-Jian, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nîmes (CHRU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), European Institute for Systems Biology and Medicine (EISBM), Epidémiologie Environnementale : Impact Sanitaire des Pollutions (EA 4064), Université Paris Descartes - Paris 5 (UPD5), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), ESIM - Déterminants Sociaux de la Santé et du Recours aux Soins (DS3), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département pneumologie et addictologie [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve, Centre de l'Asthme et des Allergies [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Trousseau [APHP], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut Albert Bonniot, Département de pédiatrie, CHU Grenoble-Hôpital Michallon, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Groningen Research Institute for Asthma and COPD (GRIAC)
- Subjects
0301 basic medicine ,Allergy ,Genome-wide association study ,Comorbidity ,Immunoglobulin E ,medicine.disease_cause ,Cohort Studies ,Translational Research, Biomedical ,0302 clinical medicine ,Allergen ,REGULATORY B-CELLS ,PRECISION MEDICINE ,Medicine ,BIRTH COHORT INFANTS ,ATOPIC-DERMATITIS ,Immunology and Allergy ,[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology ,Child ,media_common ,biology ,atopic dermatitis ,Atopic dermatitis ,3. Good health ,Europe ,Multicenter Study ,CHRONIC RESPIRATORY-DISEASES ,rhiniti ,Phenotype ,INNER-CITY CHILDREN ,Biomarker (medicine) ,Female ,atopic dermatiti ,Adolescent ,EUROPEAN INNOVATION PARTNERSHIP ,Immunology ,review ,03 medical and health sciences ,EARLY-LIFE ,Young Adult ,rhinitis ,Asthma ,Atopic Dermatitis ,Rhinitis ,Hypersensitivity ,Journal Article ,media_common.cataloged_instance ,Animals ,Humans ,European union ,MOUNTAIN CEDAR POLLINOSIS ,business.industry ,Gene Expression Profiling ,CHILDHOOD ASTHMA ,Allergens ,medicine.disease ,allergy ,030104 developmental biology ,030228 respiratory system ,biology.protein ,Immunization ,business ,Genome-Wide Association Study - Abstract
Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non–IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including invivo and invitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20years. Thirteen thousand children were prospectively followed after puberty by using a newly standardized MeDALL Core Questionnaire. Amicroarray developed for allergen molecules with increased IgE sensitivity was obtained for 3,292 children. Estimates of air pollution exposure from previous studies were available for 10,000 children. Omics data included those from historical genome-wide association studies (23,000 children) and DNA methylation (2,173), targeted multiplex biomarker (1,427), andtranscriptomic (723) studies. Using classical epidemiology and machine-learning methods in 16,147 children aged 4years and 11,080 children aged 8years, MeDALL showed the multimorbidity of eczema, rhinitis, and asthma and estimated that only 38% of multimorbidity was attributable to IgE sensitization. MeDALL has proposed a new vision of multimorbidity independent of IgE sensitization, and has shown that monosensitization and polysensitization represent 2 distinct phenotypes. The translational component of MeDALL is shown by the identification of a novel allergic phenotype characterized by polysensitization and multimorbidity, which is associated with the frequency, persistence, and severity of allergic symptoms. The results of MeDALL will help integrate personalized, predictive, preventative, and participatory approaches in allergic diseases.
- Published
- 2017
10. Increasing the Accuracy of Notification of Anaphylaxis Deaths in Brazil through the International Classification of Diseases (ICD)-11 Revision
- Author
-
Ana Luiza Bierrenbach, Moises A. Calderon, Aziz Sheikh, F. Estelle R. Simons, Luciana Kase Tanno, and Pascal Demoly
- Subjects
business.industry ,Immunology ,Immunology and Allergy ,Medicine ,Medical emergency ,business ,medicine.disease ,Anaphylaxis - Published
- 2017
11. Epidemiologic evidence for asthma and rhinitis comorbidity
- Author
-
Françoise Neukirch, Pascal Demoly, Bénédicte Leynaert, and Jean Bousquet
- Subjects
Allergy ,medicine.medical_specialty ,Immunology ,Population ,Comorbidity ,Immunoglobulin E ,Atopy ,immune system diseases ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Risk factor ,education ,Rhinitis ,Asthma ,education.field_of_study ,biology ,business.industry ,medicine.disease ,respiratory tract diseases ,Bronchial hyperresponsiveness ,biology.protein ,business ,Occupational asthma - Abstract
Asthma and rhinitis are often comorbid conditions, and the overall characteristics of the diseases and the treatment options for the disorders are similar. Several recent epidemiologic studies in the general population have provided evidence to strongly associate the development of asthma with a previous history of either allergic or perennial rhinitis. Additional links between asthma and rhinitis include a description of increased aspirin intolerance in both disorders and the observation that most subjects with occupational asthma experience rhinitis. Further, the likelihood of the development of asthma is much higher in individuals with both perennial and seasonal rhinitis than for individuals with either condition alone. Asthma and rhinitis were found to be comorbidities regardless of atopic state, and perennial rhinitis has been associated with an increase in nonspecific bronchial hyperresponsiveness. Several studies have identified rhinitis as a risk factor for asthma, with the prevalence of allergic rhinitis in asthmatic patients being 80% to 90%. These studies and others demonstrate that the coexistence of asthma and allergic rhinitis is frequent, that allergic rhinitis usually precedes asthma, and that allergic rhinitis is a risk factor for asthma. Finally, studies that have examined the age of onset of atopy as a confounding factor for the development of asthma and allergic rhinitis have suggested that early age atopy may be an important predictive factor for respiratory symptoms that continue into late childhood. In conclusion, rhinitis and asthma are strongly associated, and rhinitis has been identified as a risk factor for asthma.
- Published
- 2000
12. Systemic reactions during skin tests with β-lactams: A risk factor analysis
- Author
-
Philippe-Jean Bousquet, Pascal Demoly, Violeta Kvedariene, Christophe Fontaine, and Hoai-Bich Co Minh
- Subjects
Adult ,Hypersensitivity, Immediate ,Male ,business.industry ,Immunology ,Middle Aged ,Risk factor (computing) ,beta-Lactams ,Anti-Bacterial Agents ,Drug Hypersensitivity ,Systemic reaction ,Text mining ,Risk Factors ,β lactams ,Humans ,Immunology and Allergy ,Medicine ,Female ,business ,Skin Tests - Published
- 2006
13. Reply
- Author
-
Joerg Kleine-Tebbe and Pascal Demoly
- Subjects
Immunology ,Immunology and Allergy - Published
- 2016
14. Safety of STG320 Sublingual Tablets of House Dust Mite Allergen Extracts in Subjects with HDM-Associated Allergic Rhinitis: Results of a Pooled Analysis
- Author
-
Karl-Christian Bergmann, Robert K. Zeldin, Pascal Demoly, Sandrine Khairallah, and Kathy Abiteboul
- Subjects
030203 arthritis & rheumatology ,0301 basic medicine ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Pooled analysis ,House dust mite allergen ,business.industry ,Immunology ,Immunology and Allergy ,Medicine ,business - Published
- 2016
15. Immunological Effects of Treatment with STG320 Sublingual Tablets of House Dust Mite Allergen Extracts in Subjects with HDM-Associated Allergic Asthma
- Author
-
Robert K. Zeldin, Martine Le Gall, Patricia Rodriguez, Angélique Racaud, and Pascal Demoly
- Subjects
030203 arthritis & rheumatology ,0301 basic medicine ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,business.industry ,House dust mite allergen ,Immunology ,Immunology and Allergy ,Medicine ,Allergic asthma ,business - Published
- 2016
16. Treatment with STG320 Sublingual Tablets of House Dust Mite Allergen Extracts: Profile of Subjects with HDM-Associated Allergic Rhinitis in the Clinical Development Program
- Author
-
Karl-Christian Bergmann, Michel Roux, Pascal Demoly, Sandrine Khairallah, and Robert K. Zeldin
- Subjects
business.industry ,House dust mite allergen ,Immunology ,Immunology and Allergy ,Medicine ,business - Published
- 2016
17. Eassi Survey: European Multicentre Prospective Study to Collect Systemic Adverse Reactions Due to Allergen Immunotherapy: Pediatric Population Results
- Author
-
Pablo Rodríguez del Río, Oliver Pfaar, Pascal Demoly, Carmen Vidal, Jocelyne Just, and Moises A. Calderon
- Subjects
medicine.medical_specialty ,Allergen immunotherapy ,business.industry ,Internal medicine ,Immunology ,medicine ,Immunology and Allergy ,Prospective cohort study ,business ,Pediatric population - Published
- 2016
18. Assessment of inflammation in noninfectious chronic maxillary sinusitis
- Author
-
Lawrence B. Schwartz, Bernard Guerrier, Pascal Demoly, François B. Michel, I. Enander, Michel Mondain, Nadine Lequeuxc, Jean Bousquet, Alison M. Campbell, and Louis Crampette
- Subjects
Adult ,Hypersensitivity, Immediate ,Male ,Pathology ,medicine.medical_specialty ,Rhinitis, Allergic, Perennial ,Adolescent ,Immunology ,Tryptase ,Diagnosis, Differential ,Nonallergic rhinitis ,otorhinolaryngologic diseases ,medicine ,Humans ,Immunology and Allergy ,Eosinophilia ,Prospective Studies ,Sinusitis ,Aged ,Rhinitis ,Eosinophil cationic protein ,biology ,business.industry ,Chronic sinusitis ,Endoscopy ,Maxillary Sinus ,Middle Aged ,Eosinophil ,Maxillary Sinusitis ,Nasal Lavage Fluid ,medicine.disease ,Immunohistochemistry ,medicine.anatomical_structure ,Chronic Disease ,biology.protein ,Major basic protein ,Female ,medicine.symptom ,business - Abstract
Background and aim: Pathologic examination of the sinus mucosa and titration of inflammatory mediators in the sinus fluid were carried out to characterize inflammation in chronic sinusitis and determine whether patients with chronic allergic rhinitis (CAR) and sinusitis differ from patients with chronic nonallergic rhinitis (CNAR) and sinusitis. Methods: Nine control subjects (patients requiring ear, nose, and throat surgery not related to sinusitis), 12 patients with CAR and sinusitis, and 13 patients with CNAR and sinusitis were investigated. Eosinophil cationic protein, tryptase, myeloperoxidase, histamine, and prostaglandin D 2 were measured in the sinus lavage fluids, and cells were enumerated. The cellular infiltrate was studied by immunohistochemistry with monoclonal antibodies against eosinophil cationic protein (eosinophils), tryptase (mast cells), neutrophil elastase (neutrophils), CD3 (lymphocytes), CD68 (macrophages), and proliferating cell nuclear antigens. Results: Neutrophils were not increased in sinusitis. In comparison with control subjects, patients with CAR and CNAR with sinusitis showed significant increases in eosinophils and macrophages in biopsy specimens and in eosinophil cationic protein in sinus lavage fluids. In comparison with patients with CNAR, patients with CAR had an increased number of intraepithelial mast cells and lymphocytes. Conclusions: These findings suggest that patients with CNAR and sinusitis can be distinguished from patients with CAR and sinusitis, which resembles nonallergic rhinitis with eosinophilia syndrome. (J ALLERGY CLIN IMMUNOL 1994;94:95-108.)
- Published
- 1994
19. Airway macrophages from patients with asthma do not proliferate
- Author
-
Pascal Chanez, Philippe Vago, Pascal Demoly, Jean Bousquet, Jean Paul Bureau, Laure Cornillac, Philippe Godard, and François B. Michel
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Adolescent ,Immunology ,Immunocytochemistry ,Mice ,chemistry.chemical_compound ,Antigen ,Macrophages, Alveolar ,medicine ,Animals ,Humans ,Immunology and Allergy ,Macrophage ,Propidium iodide ,Ploidies ,medicine.diagnostic_test ,biology ,Cell Cycle ,Antibodies, Monoclonal ,Nuclear Proteins ,DNA ,Middle Aged ,Immunohistochemistry ,Asthma ,Neoplasm Proteins ,respiratory tract diseases ,Proliferating cell nuclear antigen ,Ki-67 Antigen ,Bronchoalveolar lavage ,chemistry ,Alveolar macrophage ,biology.protein ,Female ,Bronchoalveolar Lavage Fluid - Abstract
Background: Macrophages are involved in asthma, but their pulmonary turnover is unknown. We compared the ability of bronchoalveolar lavage (BAL) and bronchial macrophages to proliferate in normal subjects and patients with asthma. Methods: BAL cells from eight patients with asthma and eight normal volunteers were separated with a discontinuous Percoll gradient (Pharmacia Fine Chemicals, Uppsala, Sweden). In a first experiment, nuclei of each alveolar macrophage (AM) fraction, stained with propidium iodide, were analyzed for DNA content with a flow cytometer, and the proportions of cells in the G0G1 S, and G 2 + M phases were determined. In a second experiment, expression of Ki-67-related antigen was sought on AMs by immunocytochemistry. Macrophages from 10 patients with asthma and 10 normal volunteers were studied in biopsy specimens by means of immunohistochemistry with a panmacrophage monoclonal antibody (HAM-56) and a monoclonal antibody against proliferating cell nuclear antigen. Results: The proportions of BAL AMs in the different phases of the cell cycle were similar in normal subjects and patients with asthma for all fractions, and the percentage of cells in S and G 2 ± M phases ranged from 7.3% to 11.3%. Under 1 % of BAL AMs expressed Ki-67-related antigen. None of the macrophages present in the biopsy specimens expressed proliferating cell nuclear antigen. Conclusions: This study does not indicate that an important source of airway macrophages is local proliferation.
- Published
- 1993
20. Precision of skin prick and puncture tests with nine methods
- Author
-
H. Dhivert, Pascal Demoly, François-Bernard Michel, Sten Dreborg, Jean-Claude Manderscheid, and Jean Bousquet
- Subjects
Adult ,Analysis of Variance ,medicine.medical_specialty ,Reproducibility ,business.industry ,Coefficient of variation ,Immunology ,Reproducibility of Results ,Punctures ,Skin test ,Puncture tests ,Surgery ,Normal volunteers ,Hypersensitivity ,medicine ,Histamine Hydrochloride ,Humans ,Immunology and Allergy ,business ,Nuclear medicine ,Histamine ,Skin Tests - Abstract
New devices for puncture tests have been proposed recently, but their precision by comparison to the prick test method is poorly known. Seven puncture tests (Allerprick, Morrow Brown standardized needle, Phazer, Pricker, Stallerpointe, Stallerkit, and Wyeth bifucated needle) were compared with the modified prick test performed with hypodermic or intradermal needles in eight carefully selected normal volunteers. Skin tests with histamine hydrochloride (10 mg/ml) were only performed when there was no factor that might interfere with their interpretation. The site of skin tests on the forearm was demonstrated not to significantly influence the reaction size. The coefficient of variation of the tests ranged from 8.4% to 21.7%. Modified skin prick tests are satisfactory since they are highly reproducible (coefficient of variation: 13.4% and 16.5%) and there is no subject effect. Phazet was found to be more reproducible without subject effect. Pricker is satisfactory since it has no subject effect and a reproducibility similar to that of modified prick tests. Other tests are less reproducible (Stallerkit or Morrow Brown) or vary between subjects (Allerkit, Stallerkit, Stallerpointe, and Wyeth Needle).
- Published
- 1991
21. Physician-Patient Communication Concerning Allergen Immunotherapy: Impact on Treatment Acceptance and Compliance
- Author
-
Moises A. Calderon, Henri Farina, Sandrina Duniau, and Pascal Demoly
- Subjects
Allergen immunotherapy ,medicine.medical_specialty ,business.industry ,Physician patient communication ,Immunology ,Immunology and Allergy ,Medicine ,business ,Intensive care medicine ,Compliance (psychology) - Published
- 2015
22. The HDM Slit-Tablet Reduces Symptoms of House Dust Mite Allergic Rhinitis Independently of Asthma Status and Allergen Sensitisation Type; A Subgroup Analysis of Results from a Dbpc Phase III Trial (MERIT)
- Author
-
Kjersti Moen, J. Kleine-Tebbe, Pascal Demoly, and Dorte Rehm
- Subjects
House dust mite ,Allergy ,medicine.medical_specialty ,Randomization ,biology ,Visual analogue scale ,business.industry ,Immunology ,Environmental exposure ,medicine.disease ,medicine.disease_cause ,Placebo ,biology.organism_classification ,Allergen ,Internal medicine ,medicine ,Immunology and Allergy ,business ,Asthma - Abstract
T U E S D A Y 871 Treatment Effect of House Dust Mite Sublingual Immunotherapy Tablet for Allergic Rhinitis with/without Conjunctivitis Hendrik Nolte, MD, PhD, Jennifer Maloney, MD, Amarjot Kaur, PhD, Harold S. Nelson, MD, FAAAAI, David I. Bernstein, MD, FAAAAI, Ziliang Li, PhD, Susan Lu, PharmD, Friedrich Horak, MD; Merck & Co., Inc., Whitehouse Station, NJ, National Jewish Health, Denver, CO, Bernstein Allergy Group, Cincinnati, OH, Vienna Challenge Chamber, Vienna, Austria. RATIONALE: Overall treatment effect of a house dust mite (HDM) sublingual immunotherapy tablet (SLIT-tablet) evaluated in an environmental exposure chamber trial was explored by measuring rhinoconjunctivitis symptoms and quality-of-life outside the controlled exposure challenges (pre-challenge). METHODS: In this double-blind, 24-week trial, adults (n5124) with HDM-induced allergic rhinitis with/without conjunctivitis (AR/C) received daily HDM SLIT-tablet (Merck/ALK-Abell o [MK-8237]) 12DU, 6-DU, or placebo. At randomization (baseline) and pre-challenge (weeks 8, 16, and 24), subjects evaluated severity of rhinoconjunctivitis symptoms experienced in their natural environment over the previousweek on a visual analog scale (VAS; range 02100), and completed Rhinoconjunctivitis Quality-of-Life Questionnaires With Standardized Activities (RQLQ[S]; range 026). Pre-specified immunologic parameters were assessed at screening, week 8, and post-hoc at week 24. RESULTS: VAS with placebo and 6-DU worsened 31% and 3%, respectively, from baseline to week 24, and improved 28% with 12-DU. At week 24, VAS improved 49% with 12-DU versus placebo (mean difference: 218.41 points; P50.001). RQLQ(S) with placebo worsened 9% from baseline to week 24, and improved 8% and 11% with 6and 12-DU, respectively. At week 24, RQLQ(S) improved 26% with 12-DU versus placebo (mean difference:20.64; P50.007). No significant difference for VAS or RQLQ(S) was observed with 6-DU versus placebo at any timepoint. Specific IgE and IgG4 increased with 6and 12-DU treatment versus placebo at week 8 (P
- Published
- 2015
23. Reply
- Author
-
A. Bazin, B Lamy, Pascal Demoly, D. Laroche, Leconte des Floris Mf, Jean-Yves Py, C. Caldani, Paul-Michel Mertes, Christian Drouet, A Lienhart, Jacques Bienvenu, Annick Alpérovitch, and M. Carlier
- Subjects
business.industry ,Immunology ,Immunology and Allergy ,Medicine ,business - Published
- 2013
24. Efficacy and safety of sublingual tablets of house dust mite allergen extracts in adults with allergic rhinitis
- Author
-
Robert K. Zeldin, Ana I. Tabar, Teresa Carrillo, Hélène Nguyen, A. Montagut, Margitta Worm, Karl Christian Bergmann, Pascal Demoly, Wytske Fokkens, AII - Amsterdam institute for Infection and Immunity, and Ear, Nose and Throat
- Subjects
Adult ,Male ,medicine.medical_specialty ,Allergen immunotherapy ,Rhinitis, Allergic, Perennial ,Immunology ,Administration, Sublingual ,Placebo ,medicine.disease_cause ,Young Adult ,Allergen ,Internal medicine ,Animals ,Humans ,Immunology and Allergy ,Medicine ,Antigens, Dermatophagoides ,Adverse effect ,Skin Tests ,House dust mite ,biology ,business.industry ,House dust mite allergen ,Pyroglyphidae ,Immunoglobulin E ,medicine.disease ,biology.organism_classification ,Rhinitis, Allergic ,Surgery ,Treatment Outcome ,Desensitization, Immunologic ,Immunoglobulin G ,Female ,Onset of action ,business ,Anaphylaxis ,Tablets - Abstract
Background Preliminary studies have suggested the efficacy of sublingual tablets of house dust mite (HDM) extracts in adults with allergic rhinitis. Objectives We sought to assess the efficacy and safety of 2 doses of HDM sublingual tablets over 1 treatment year and the subsequent immunotherapy-free year. Methods Adults with HDM-associated allergic rhinitis were randomized in a double-blind, placebo-controlled study to receive 500 index of reactivity (IR) tablets, 300IR tablets, or placebo administered once daily for 1 year and were followed for the subsequent year. The primary efficacy variable was the Average Adjusted Symptom Score over the year 1 primary period (ie, October 1 to December 31). Symptoms and rescue medication scores, onset of action, patient-reported outcomes, and safety were secondary variables. The same end points were evaluated during the immunotherapy-free year. The primary efficacy end point was analyzed by using analysis of covariance. Results Five hundred nine participants were randomized, and 427 continued in the immunotherapy-free year. Both the 500IR and 300IR HDM sublingual tablets significantly reduced mean Average Adjusted Symptom Scores compared with placebo by −20.2% ( P = .0066) and −17.9% ( P = .0150), respectively. Efficacy of both doses was maintained during the treatment-free follow-up phase. The onset of action was at 4 months. Participants' global evaluation of treatment success was significantly higher in the 500IR and 300IR groups compared with the placebo group ( P = .0206 and P = .0001, respectively). Adverse events were generally application-site reactions. There were no reports of anaphylaxis. Conclusions Twelve months of treatment with 500IR and 300IR sublingual tablets of HDM allergen extracts was efficacious and well tolerated. Efficacy was maintained during the treatment-free follow-up year.
- Published
- 2014
25. Reply
- Author
-
Philippe Jean Bousquet and Pascal Demoly
- Subjects
Immunology ,Immunology and Allergy - Published
- 2005
26. Anaphylactic shock caused by a selective allergy to celecoxib, with no allergy to rofecoxib or sulfamethoxazole
- Author
-
Philippe-Jean Bousquet, Pascal Demoly, and Christophe Fontaine
- Subjects
Allergy ,business.industry ,Sulfamethoxazole ,Anesthesia ,Immunology ,Celecoxib ,medicine ,Anaphylactic shock ,Immunology and Allergy ,medicine.disease ,business ,Rofecoxib ,medicine.drug - Published
- 2005
27. Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report
- Author
-
Moises A. Calderon, Cezmi A. Akdis, A.W. Burks, Harold S. Nelson, Pascal Demoly, Linda Cox, Marek Jutel, Thomas B. Casale, University of Zurich, and Burks, A Wesley
- Subjects
Allergy ,medicine.medical_treatment ,Immunology ,610 Medicine & health ,Disease ,medicine.disease_cause ,03 medical and health sciences ,0302 clinical medicine ,Allergen ,10183 Swiss Institute of Allergy and Asthma Research ,Food allergy ,Hypersensitivity ,medicine ,Humans ,Immunology and Allergy ,Societies, Medical ,030304 developmental biology ,Asthma ,2403 Immunology ,0303 health sciences ,business.industry ,Immunotherapy ,Atopic dermatitis ,medicine.disease ,United States ,3. Good health ,Europe ,030228 respiratory system ,Desensitization, Immunologic ,2723 Immunology and Allergy ,business ,Anaphylaxis - Abstract
Allergy immunotherapy (AIT) is an effective treatment for allergic asthma and rhinitis, as well as venom-induced anaphylaxis. In addition to reducing symptoms, AIT can change the course of allergic disease and induce allergen-specific immune tolerance. In current clinical practice immunotherapy is delivered either subcutaneously or sublingually; some allergens, such as grass pollen, can be delivered through either route, whereas others, such as venoms, are only delivered subcutaneously. Both subcutaneous and sublingual immunotherapy appear to have a duration of efficacy of up to 12 years, and both can prevent the development of asthma and new allergen sensitivities. In spite of the advances with AIT, safer and more effective AIT strategies are needed, especially for patients with asthma, atopic dermatitis, or food allergy. Novel approaches to improve AIT include use of adjuvants or recombinant allergens and alternate routes of administration. As part of the PRACTALL initiatives, the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology nominated an expert team to develop a comprehensive consensus report on the mechanisms of AIT and its use in clinical practice, as well as unmet needs and ongoing developments in AIT. This resulting report is endorsed by both academies.
- Published
- 2013
28. Onset of Action of Sublingual Tablets of House Dust Mite Allergen Extracts in Adults
- Author
-
Karl-Christian Bergmann, Hélène Nguyen, Robert K. Zeldin, Marine Frereux, Pascal Demoly, and Michel Melac
- Subjects
business.industry ,House dust mite allergen ,Immunology ,Immunology and Allergy ,Medicine ,Onset of action ,business - Published
- 2013
29. Sublingual Allergen Immunotherapy: Mode Of Action And Its Relationship With The Safely Profile
- Author
-
Philippe Moingeon, Hans-Jørgen Malling, Richard F. Lockey, Pascal Demoly, Elinor Simons, and Moises A. Calderon
- Subjects
Allergen immunotherapy ,business.industry ,Immunology ,Immunology and Allergy ,Medicine ,Mode of action ,business - Published
- 2012
30. Relative transactivation and transrepression potencies of fluticasone propionate (FP) and mometasone furoate (MF)
- Author
-
Malcolm Johnson, Corinne Henriquet, C. Roumestan, Marc Mathieu, Pascal Demoly, and Jean Bousquet
- Subjects
Transactivation ,Chemistry ,Immunology ,medicine ,Immunology and Allergy ,Mometasone furoate ,Pharmacology ,Fluticasone propionate ,Transrepression ,medicine.drug - Published
- 2002
31. Post-treatment Efficacy Of House Dust Mites (HDM) Sublingual Immunotherapy (SLIT) Tablets In Adult Patients
- Author
-
Hélène Nguyen, Michel Melac, O. de Beaumont, Ana I. Tabar, K. C. Bergmann, W. J. Fokkens, Margitta Worm, Pascal Demoly, and A. Montagut
- Subjects
Adult patients ,business.industry ,Immunology ,Immunology and Allergy ,Medicine ,Sublingual immunotherapy ,Dust mites ,Post treatment ,business ,Slit - Published
- 2011
32. From Evidence-Based Medicine to Practice in Specific Grass Pollen Immunotherapy of Seasonal Allergic Rhinoconjunctivitis
- Author
-
Ralph Mösges, Pascal Demoly, Moises A. Calderon, and Martin Hellmich
- Subjects
Grass pollen ,medicine.medical_treatment ,Immunology ,medicine ,Immunology and Allergy ,Evidence-based medicine ,Immunotherapy ,Biology ,Seasonal allergic rhinoconjunctivitis - Published
- 2010
33. Efficacy and Safety of House Dust Mites Allergen Extracts Tablets in Adults With Allergic Rhinitis Patients
- Author
-
O. de Beaumont, Margitta Worm, K. C. Bergmann, Hélène Nguyen, Pascal Demoly, Michel Melac, Ana I. Tabar, and W. J. Fokkens
- Subjects
Allergen ,business.industry ,Immunology ,medicine ,Immunology and Allergy ,Dust mites ,medicine.disease_cause ,business - Published
- 2010
34. Trimethoprim-sulfamethoxazole–graded challenge in HIV-infected patients: Long-term follow-up regarding efficacy and safety
- Author
-
D. Messaad, Jacques Reynes, Jean Bousquet, Pascal Demoly, and Vincent Faucherre
- Subjects
medicine.medical_specialty ,Time Factors ,Immunology ,HIV Infections ,Drug Hypersensitivity ,Pharmacotherapy ,Acquired immunodeficiency syndrome (AIDS) ,Internal medicine ,Trimethoprim, Sulfamethoxazole Drug Combination ,Immune Tolerance ,medicine ,Humans ,Immunology and Allergy ,Sida ,Adverse effect ,Mycosis ,biology ,business.industry ,Sulfamethoxazole ,biology.organism_classification ,medicine.disease ,Trimethoprim ,Pneumocystis Infections ,Therapeutic Equivalency ,Viral disease ,business ,Follow-Up Studies ,medicine.drug - Published
- 2000
35. Nevirapine-induced cutaneous hypersensitivity reactions and successful tolerance induction☆☆☆★
- Author
-
Jacques Reynes, Pascal Demoly, Jacqueline Fabre, Jean Bousquet, and D. Messaad
- Subjects
Adult ,Male ,Chemotherapy ,Nevirapine ,Urticaria ,Reverse-transcriptase inhibitor ,medicine.medical_treatment ,Immunology ,HIV Infections ,Drug Tolerance ,Biology ,Tolerance induction ,Immunopathology ,Toxicity ,Cutaneous hypersensitivity ,medicine ,Humans ,Reverse Transcriptase Inhibitors ,Immunology and Allergy ,Female ,Skin Tests ,medicine.drug - Published
- 1999
36. Characterization of Patients Sensitized to Cefuroxim
- Author
-
N. Soohun, B. Arnoux, Pascal Demoly, Philippe-Jean Bousquet, and L. Rouanet-Bousquet
- Subjects
Chemistry ,Immunology ,Immunology and Allergy ,Molecular biology ,Characterization (materials science) - Published
- 2008
37. Safety and Tolerability of House Dust Mite Tablets in Sublingual Immunotherapy
- Author
-
Michel Melac, Pascal Demoly, M. LeGall, Claude André, and L. Meziane
- Subjects
House dust mite ,medicine.medical_specialty ,biology ,Tolerability ,business.industry ,Immunology ,Immunology and Allergy ,Medicine ,Sublingual immunotherapy ,biology.organism_classification ,business ,Dermatology - Published
- 2008
38. Severity of Allergic Reactions to Drugs
- Author
-
Jean Bousquet, B. Arnoux, Philippe-Jean Bousquet, Pascal Demoly, and L. Bousquet-Rouanet
- Subjects
Immunology ,Immunology and Allergy - Published
- 2006
39. Time Course of Allergic Reactions to Drugs
- Author
-
Philippe-Jean Bousquet, Jean Bousquet, Pascal Demoly, H.-B. Co-Minh, and B. Arnoux
- Subjects
medicine.medical_specialty ,business.industry ,Immunology ,Time course ,medicine ,Immunology and Allergy ,Intensive care medicine ,business - Published
- 2006
40. Variation of Basophil CD63 Expression in Drug Hypersensitivity Patients According to their in Vivo Test
- Author
-
M. Rongier, Pascal Demoly, Violeta Kvedariene, and B. Arnoux
- Subjects
Drug ,Variation (linguistics) ,medicine.anatomical_structure ,CD63 ,In vivo ,media_common.quotation_subject ,Immunology ,medicine ,Immunology and Allergy ,Basophil ,Biology ,media_common - Published
- 2006
41. Expression of CD203 on basophils from allergic and non-allergic subjects
- Author
-
J. Vernier, C. Canino, Felix A. Montero-Julian, B. Arnoux, Gaëlle Bouvier, M. Rongier, and Pascal Demoly
- Subjects
Expression (architecture) ,business.industry ,Immunology ,Non allergic ,Immunology and Allergy ,Medicine ,business - Published
- 2005
42. Desloratadine inhibits basal and histamine-induced NF-kB activity via the histamine receptor 1*1
- Author
-
Marc Mathieu, Jean Bousquet, C. Gougat-Barbera, Corinne Henriquet, C. Roumestan, and Pascal Demoly
- Subjects
A549 cell ,Thioperamide ,Chemistry ,Immunology ,Histamine H1 receptor ,Pharmacology ,Histamine receptor ,chemistry.chemical_compound ,medicine ,Immunology and Allergy ,Inverse agonist ,Histamine H4 receptor ,Cimetidine ,Histamine ,medicine.drug - Abstract
Rationale Desloratadine (DL) is a new potent and selective H1 receptor antagonist (AH1) that also acts on inflammatory mediators and NF-kB activity. The aim of our study was to evaluate the involvement of the histamine receptor 1 (H1R) in the anti-inflammatory effects of DL. Methods The H1R cDNA was cloned by RT-PCR to construct the expression vector pCIH1R. After transfection with pCIH1R, overexpression of the H1R in A549 cells was confirmed by Western blotting and immunocytochemistry. Using reporter gene assays, we evaluated the effect of DL, but also diphenhydramine (DPH), a first generation AH1, cimetidine, an AH2, and thioperamide, an AH3, on NF-kB activity in pCIH1R or mock transfected A549 cells. Results Overexpression of the H1R resulted in increased NF-kB basal activity. DL significantly inhibited this basal activity in both mock transfected and pCIH1R transfected A549 cells. This effect was weaker for DPH and not significant for the AH2 and the AH3. Histamine failed to induce NF-kB activity in mock transfected cells but significantly induced this activity in pCIH1R transfected cells. DL inhibited histamine-induced NF-kB activity by 68% (p Conclusions These results suggest that DL can inhibit both basal and histamine-induced NF-kB activity by acting, in the first case, as an inverse agonist at the H1R, and in the second case as a classic H1R antagonist. Thus, the H1R seems to play a major role in the anti-inflammatory effects of DL.
- Published
- 2004
43. $beta;-lactam allergy in clinical practice, relevance of clinical history and/or laboratory test*1
- Author
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Pascal Demoly, Jean Bousquet, B. Arnoux, M. Rongier, and Violeta Kvedariene
- Subjects
education.field_of_study ,Allergy ,medicine.medical_specialty ,Angioedema ,Clinical pathology ,business.industry ,Immunology ,Provocation test ,Drug allergy ,Population ,medicine.disease ,Hypersensitivity reaction ,medicine.anatomical_structure ,medicine ,Immunology and Allergy ,medicine.symptom ,business ,education ,Sensitization - Abstract
Rationale Hypersensitivity reactions to β-lactam are common and may be severe, these include immediate (IgE-mediated) and non-immediate reactions. The value of biological test like; basophil degranulation test, in a non-selected population of patients suspected of drug allergy has never been fully established. Methods We randomly studied 35 patients who consulted for a suspected immediate hypersensitivity reaction to β-lactams. Clinical history, skin tests or drug provocation test (DPT) and/or serum specific IgE antibodies were performed to establish the diagnosis of allergy to β-lactam. The Basotest, based upon the expression of CD63 in the presence of specific allergens was evaluated as biological test to confirmed the clinical analysis in this unselected population. 35 β-lactam suspected allergic patients (13 urticaria, 9 macula papular eruption, 7 choc, 3 angioedema), 40 atopic subjects non-allergic to β-lactam were studied. History, provocation test and Basotest, to detect a specific sensitization to β-lactam were studied in all subjects. Results No statistical difference in the basal CD63 expression was observed between basophils of β-lactam allergic patients and those from control subject. In the 35 β-lactam allergic patients, Basotest, was positive in 3 subjects, two with a confirmed allergy (amoxicillin or ceftriaxon) and another one with a negative DPT (ceftriaxon), all control were negative. Conclusion This study does not confirm the data of Sanz et al (Clin Exp Allergy 2002) who used a different method of activation of basophils and analysis method. Thus, the Basotest® cannot be used in patients with immediate hypersensitivity reactions to β-lactams.
- Published
- 2004
44. Diagnosis of natural rubber latex allergy by the Basotest method*1
- Author
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Pascal Demoly, M. Rongier, R. Verdier, H. Dhivert-Donnadieu, B. Arnoux, M.-L. Hemery, and E. Barbotte
- Subjects
House dust mite ,Allergy ,biology ,business.industry ,Immunology ,biology.organism_classification ,Immunoglobulin E ,medicine.disease ,Control subjects ,Basophil activation ,Latex allergy ,Natural Rubber Latex Allergy ,biology.protein ,Cypress pollen ,Immunology and Allergy ,Medicine ,business - Abstract
Rationale The flow cytometry CD63 based basophil activation test (Basotest®) has already been validated for the diagnosis of immediate-type allergy such as venom, house dust mite or cypress pollen allergies. The aim of this study was to evaluate the interest of Basotest® for the diagnosis of natural rubber latex allergy. Methods We included 46 latex allergic patients (who presented clinical symptoms of latex allergy, positive latex skin prick tests and specific IgE) and 33 control subjects and performed Basotest® in all subjects. Results The sensitivity and specificity of Basotest® were 84.8% and 87.9% respectively when we considered the cut-off at 15% of CD63 positive cells. Using ROC curves, the optimal cut-off was evaluated at 22%, for which sensitivity and specificity were 79.3% and 96.7% respectively. Conclusion The Basotest® is a reliable test in complement to clinical history and already validated tests (such as skin prick tests and specific IgE) to confirm the diagnosis of natural rubber latex allergy.
- Published
- 2004
45. Interest and limits of basotest® in the detection of allergic diseases
- Author
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M. Rongier, Pascal Demoly, B. Lebel, Jean Bousquet, and B. Arnoux
- Subjects
Immunology ,Immunology and Allergy - Published
- 2003
46. Validation of pharmacovigilance algorithms in drug hypersensitivity reactions
- Author
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Jean Bousquet, Pascal Demoly, D. Hillaire-Buys, D. Messaad, P. Godard, and S. Benahmed
- Subjects
Drug ,medicine.medical_specialty ,business.industry ,media_common.quotation_subject ,Immunology ,Pharmacovigilance ,medicine ,Immunology and Allergy ,Pharmacology ,Intensive care medicine ,business ,media_common - Published
- 2003
47. 1013 Are sulfidoleukotrienes and histamine releases useful for the diagnosis of drug hypersensitivity?
- Author
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B. Lebel, Pascal Demoly, D. Messaad, M. Rongier, and Jean Bousquet
- Subjects
Drug ,business.industry ,media_common.quotation_subject ,Immunology ,Histamine Releases ,Immunology and Allergy ,Medicine ,Pharmacology ,business ,media_common - Published
- 2000
48. 809 Conjunctival challenge with codeine phosphate
- Author
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I. Couret, Pascal Demoly, Alison M. Campbell, Jean Bousquet, M.C. Richard, I. Enander, and F.B. Michel
- Subjects
business.industry ,Conjunctival challenge ,Immunology ,Immunology and Allergy ,Medicine ,Codeine Phosphate ,Pharmacology ,business - Published
- 1991
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