Back to Search
Start Over
Mechanisms of the Development of Allergy (MeDALL) : Introducing novel concepts in allergy phenotypes
- Source :
- Journal of Allergy and Clinical Immunology, 139(2), 388. Mosby Inc., JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, r-FISABIO: Repositorio Institucional de Producción Científica, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO), Antó, J M, Bousquet, J, Akdis, M, Auffray, C, Keil, T, Momas, I, Postma, D S, Valenta, R, Wickman, M, Cambon-Thomsen, A, Haahtela, T, Lambrecht, B N, Lodrup Carlsen, K C, Koppelman, G H, Sunyer, J, Zuberbier, T, Annesi-Maesano, I, Arno, A, Bindslev-Jensen, C, De Carlo, G, Forastiere, F, Heinrich, J, Kowalski, M L, Maier, D, Melén, E, Smit, H A, Standl, M, Wright, J, Asarnoj, A, Benet, M, Ballardini, N, Garcia-Aymerich, J, Gehring, U, Guerra, S, Hohmann, C, Kull, I, Lupinek, C, Pinart, M, Skrindo, I, Westman, M, Smagghe, D, Akdis, C A, Andersson, N, Bachert, C, Ballereau, S, Ballester, F, Basagaña, X, Bedbrook, A, Bergstrom, A, von Berg, A, Brunekreef, B, Burte, E, Carlsen, K-H, Chatzi, L, Coquet, J M, Curin, M, Demoly, P, Eller, E, Fantini, M P, von Hertzen, L, Hovland, V, Jacquemin, B, Just, J, Keller, T, Kiss, R, Kogevinas, M, Koletzko, S, Lau, S, Lehmann, I, Lemonnier, N, Mäkelä, M, Mestres, J, Mowinckel, P, Nadif, R, Nawijn, M C, Pellet, J, Pin, I, Porta, D, Rancière, F, Rial-Sebbag, E, Saeys, Y, Schuijs, M J, Siroux, V, Tischer, C G, Torrent, M, Varraso, R, Wenzel, K & Xu, C-J 2017, ' Mechanisms of the Development of Allergy (MeDALL) : Introducing novel concepts in allergy phenotypes ', Journal of Allergy and Clinical Immunology, vol. 139, no. 2, pp. 388-399 . https://doi.org/10.1016/j.jaci.2016.12.940, Journal of Allergy and Clinical Immunology, Journal of Allergy and Clinical Immunology, Elsevier, 2017, 139 (2), pp.388-399. ⟨10.1016/j.jaci.2016.12.940⟩, Journal of Allergy and Clinical Immunology, 2017, 139 (2), pp.388-399. ⟨10.1016/j.jaci.2016.12.940⟩, r-FISABIO. Repositorio Institucional de Producción Científica, instname, J. Allergy Clin. Immunol. 139, 388-399 (2017), Journal of Allergy and Clinical Immunology, 139(2), 388-399. MOSBY-ELSEVIER
- Publication Year :
- 2017
-
Abstract
- Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non–IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including invivo and invitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20years. Thirteen thousand children were prospectively followed after puberty by using a newly standardized MeDALL Core Questionnaire. Amicroarray developed for allergen molecules with increased IgE sensitivity was obtained for 3,292 children. Estimates of air pollution exposure from previous studies were available for 10,000 children. Omics data included those from historical genome-wide association studies (23,000 children) and DNA methylation (2,173), targeted multiplex biomarker (1,427), andtranscriptomic (723) studies. Using classical epidemiology and machine-learning methods in 16,147 children aged 4years and 11,080 children aged 8years, MeDALL showed the multimorbidity of eczema, rhinitis, and asthma and estimated that only 38% of multimorbidity was attributable to IgE sensitization. MeDALL has proposed a new vision of multimorbidity independent of IgE sensitization, and has shown that monosensitization and polysensitization represent 2 distinct phenotypes. The translational component of MeDALL is shown by the identification of a novel allergic phenotype characterized by polysensitization and multimorbidity, which is associated with the frequency, persistence, and severity of allergic symptoms. The results of MeDALL will help integrate personalized, predictive, preventative, and participatory approaches in allergic diseases.
- Subjects :
- 0301 basic medicine
Allergy
Genome-wide association study
Comorbidity
Immunoglobulin E
medicine.disease_cause
Cohort Studies
Translational Research, Biomedical
0302 clinical medicine
Allergen
REGULATORY B-CELLS
PRECISION MEDICINE
Medicine
BIRTH COHORT INFANTS
ATOPIC-DERMATITIS
Immunology and Allergy
[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology
Child
media_common
biology
atopic dermatitis
Atopic dermatitis
3. Good health
Europe
Multicenter Study
CHRONIC RESPIRATORY-DISEASES
rhiniti
Phenotype
INNER-CITY CHILDREN
Biomarker (medicine)
Female
atopic dermatiti
Adolescent
EUROPEAN INNOVATION PARTNERSHIP
Immunology
review
03 medical and health sciences
EARLY-LIFE
Young Adult
rhinitis
Asthma
Atopic Dermatitis
Rhinitis
Hypersensitivity
Journal Article
media_common.cataloged_instance
Animals
Humans
European union
MOUNTAIN CEDAR POLLINOSIS
business.industry
Gene Expression Profiling
CHILDHOOD ASTHMA
Allergens
medicine.disease
allergy
030104 developmental biology
030228 respiratory system
biology.protein
Immunization
business
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 00916749
- Volume :
- 139
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of Allergy and Clinical Immunology
- Accession number :
- edsair.doi.dedup.....58ad46167e3f6361252ad9da908b24cf