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Your search keyword '"O'BRIEN, STEPHEN J."' showing total 5 results
Start Over Author "O'BRIEN, STEPHEN J." Topic hiv infections Journal jaids: journal of acquired immune deficiency syndromes
5 results on '"O'BRIEN, STEPHEN J."'

1. Using Mutual Information to Measure the Impact of Multiple Genetic Factors on AIDS.

Author

Nelson, George W. and O'Brien, Stephen J.

Subjects
*AIDS, *GENETICS, *CHEMOKINES, *VIRAL receptors, *HIV infections
Abstract

The article reports on the utilization of mutual information in the measurement of the impact of multiple genetic factors on AIDS. The discovery of the 32-base-pair deletion in the CCR5 chemokine receptor gene and its effect on HIV-1 infection led to the identification of genetic factors affecting AIDS. The influence of causal factors on disease is usually measured by the attributable fraction statistic. It revealed that 13 genetic factors can explain nine percent of slow progression to AIDS.

Published
2006
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2. Host Genetic Influences on Highly Active Antiretroviral Therapy Efficacy and AIDS-Free Survival.

Author

Hendrickson, Sher L., Jacobson, Lisa P., Nelson, George W., Phair, John P., Lautenberger, James, Johnson, Randall C., Kingsley, Lawrence, Margolick, Joseph B., Detels, Roger, Goedert, James J., and O'Brien, Stephen J.

Subjects
*AIDS, *HIV infections, *HIV, *ANTIVIRAL agents, *THERAPEUTICS
Abstract

The article studies the influence of AIDS restriction genes and haplotypes of the CCR5 P1 promoter and RANTES variants among HIV-1 infected patients on highly active antiretroviral therapy in the Multicenter AIDS Cohort Study and the Multicenter Hemophilia Cohort Study. It examines a range of genes that were predicted to influence HAART through various interactions with the HIV life cycle and drug metabolism.

Published
2008
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3. Dominant Effects of CCR2-CCRS Haplotypes in HIV-1 Disease Progression.

Author

Winkler, Cheryl A., Hendel, Houria, Carrington, Mary, Smith, Michael W., Nelson, George W., O'Brien, Stephen J., Phair, John, Vlahov, David, Jacobson, Lisa P., Rappaport, Jay, Vasilescu, Alexandre, Bertin-Maghit, Sebastien, Ping An, Wei Lu, Andrieu, Jean-Marie, Schächter, Fran çois, Therwath, Amu, and Zagury, Jean-François

Subjects
*CHEMOKINES, *INFLAMMATORY mediators, *AIDS, *HIV infections, *PROMOTERS (Genetics), *GENETIC transcription
Abstract

Reports the relative contributions to AIDS progression of three promoter haplotypes of CCR2-CCR5. Comparison of the rapid progression with a seroconverter control group including intermediate progressors to AIDS; Data indicating that factors other than CCR5 or CCR2 genetic variants must be responsible for the long-term maintenance of nonprogression.

Published
2004
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4. Lack of Associations Between HLA Class II Alleles and Resistance to HIV-1 Infection Among White, Non-Hispanic Homosexual Men.

Author

Liu, Chenglong, Carrington, Mary, Kaslow, Richard A., Gao, Xiaojiang, Rinaldo, Charles R., Jacobson, Lisa P., Margolick, Joseph B., Phair, John, O'Brien, Stephen J., and Detels, Roger

Subjects
*HLA class II antigens, *NATURAL immunity, *HIV infections, *GAY men, *WHITE men, *WHITE people, *AIDS
Abstract

Discusses the lack of associations between HLA class II alleles and resistance to HIV-1 infection among white, non-Hispanic, gay men. HLA class II alleles were molecularly typed for 100 high-risk seronegative men; Transporter associated with antigen presentation 2; Linkage disequilibrium with some HLA class II alleles.

Published
2004
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5. Effect of Host Genetics on Incidence of HIV Neuroretinal Disorder in Patients With AIDS.

Author

Sezgin, Efe, Hendrickson, Sher L., Jabs, Douglas A., Van Natta, Mark L., Lewis, Richard A., Troyer, Jennifer L., and O'Brien, Stephen J.

Subjects
*HIV-positive persons, *AIDS, *CONTRAST sensitivity (Vision), *GENES, *ANTIVIRAL agents, *HIV infections, *RETINAL degeneration, *HIV, *PATIENTS
Abstract

The article presents a study on the effect of host genetics on human immunodeficiency virus neuroretinal disorder (HIV-NRD) in patients with AIDS. It notes the loss of contrast sensitivity that is sufficient to impair reading speed. It mentions the validated AIDS restriction gene variants in evaluating the effect of host genes on HIV-NRD which has been implicated to influence HIV-1 infection, AIDS progression, therapy response, and antiviral drug metabolism.

Published
2010
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