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1. TLR9 Polymorphisms Might Contribute to the Ethnicity Bias for EBV-Infected Nasopharyngeal Carcinoma

Author

Nabanita Roy Chattopadhyay, Koustav Chatterjee, Nikhil Tiwari, Sudipta Chakrabarti, Sushil Kumar Sahu, Sankar Deb Roy, Arijit Ghosh, R. Rajendra Reddy, Piyanki Das, Sudipa Mal, Basab Bijay Karnar, Ashok Kumar Das, Sam Tsering, Komri Riba, Zoreng puii, Eric Zomawia, Y. Indibar Singh, Amol Ratnakar Suryawanshi, Abhishek Kumar, Dipyaman Ganguly, Chandan Goswami, and Tathagata Choudhuri

Subjects
Science
Abstract

Summary: Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world, but is endemic in some ethnic groups. The association of NPC with the Epstein-Barr virus (EBV) is firmly established; however, the mechanism is still unclear. TLR9 is well known for its essential role in viral pathogen recognition and activation of innate immunity. Here, we report a set of TLR9 polymorphisms in the TIR-2 domain of the TLR9 protein collected from the EBV-infected NPC samples from northeast Indian populations sharing the aforesaid ethnicity. The occurrence of mutations is significantly high in these samples as we found a p value of

Published
2020
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2. TLR9 Polymorphisms Might Contribute to the Ethnicity Bias for EBV-Infected Nasopharyngeal Carcinoma

Author

Y. Indibar Singh, Abhishek Kumar, Sudipta Chakrabarti, Komri Riba, Sudipa Mal, Koustav Chatterjee, Piyanki Das, Eric Zomawia, Dipyaman Ganguly, Sankar Deb Roy, Chandan Goswami, Ashok Kumar Das, Sam Tsering, Sushil Kumar Sahu, Basab Bijay Karnar, Amol Suryawanshi, Zoreng puii, Nikhil Tiwari, Nabanita Roy Chattopadhyay, R. Rajendra Reddy, Arijit Ghosh, and Tathagata Choudhuri

Subjects
0301 basic medicine, 02 engineering and technology, Biology, Malignancy, Article, Virus, 03 medical and health sciences, medicine, lcsh:Science, Pathogen, Cancer, Multidisciplinary, Innate immune system, TLR9, Human Genetics, Biological Sciences, 021001 nanoscience & nanotechnology, medicine.disease, Human genetics, stomatognathic diseases, 030104 developmental biology, Nasopharyngeal carcinoma, Immunology, lcsh:Q, 0210 nano-technology
Abstract

Summary Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world, but is endemic in some ethnic groups. The association of NPC with the Epstein-Barr virus (EBV) is firmly established; however, the mechanism is still unclear. TLR9 is well known for its essential role in viral pathogen recognition and activation of innate immunity. Here, we report a set of TLR9 polymorphisms in the TIR-2 domain of the TLR9 protein collected from the EBV-infected NPC samples from northeast Indian populations sharing the aforesaid ethnicity. The occurrence of mutations is significantly high in these samples as we found a p value of, Graphical Abstract, Highlights • EBV-associated nasopharyngeal carcinoma (NPC) is endemic in Mongoloids • TLR9 is essential for virus recognition and immunity against cancers • Polymorphisms are common in TLR9 protein in EBV-infected Mongoloids with NPC • NPC susceptibility prediction by TLR9 mutation screening in people for prevention, Biological Sciences; Human Genetics; Cancer

Published
2020

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