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TLR9 Polymorphisms Might Contribute to the Ethnicity Bias for EBV-Infected Nasopharyngeal Carcinoma

TLR9 Polymorphisms Might Contribute to the Ethnicity Bias for EBV-Infected Nasopharyngeal Carcinoma

Authors :
Nabanita Roy Chattopadhyay
Koustav Chatterjee
Nikhil Tiwari
Sudipta Chakrabarti
Sushil Kumar Sahu
Sankar Deb Roy
Arijit Ghosh
R. Rajendra Reddy
Piyanki Das
Sudipa Mal
Basab Bijay Karnar
Ashok Kumar Das
Sam Tsering
Komri Riba
Zoreng puii
Eric Zomawia
Y. Indibar Singh
Amol Ratnakar Suryawanshi
Abhishek Kumar
Dipyaman Ganguly
Chandan Goswami
Tathagata Choudhuri
Source :
iScience, Vol 23, Iss 3, Pp - (2020)
Publication Year :
2020
Publisher :
Elsevier, 2020.

Abstract

Summary: Nasopharyngeal carcinoma (NPC) is a rare malignancy in most parts of the world, but is endemic in some ethnic groups. The association of NPC with the Epstein-Barr virus (EBV) is firmly established; however, the mechanism is still unclear. TLR9 is well known for its essential role in viral pathogen recognition and activation of innate immunity. Here, we report a set of TLR9 polymorphisms in the TIR-2 domain of the TLR9 protein collected from the EBV-infected NPC samples from northeast Indian populations sharing the aforesaid ethnicity. The occurrence of mutations is significantly high in these samples as we found a p value of

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
25890042
Volume :
23
Issue :
3
Database :
Directory of Open Access Journals
Journal :
iScience
Publication Type :
Academic Journal
Accession number :
edsdoj.6b1e0dd7ccde4062b6dfecbd26ab9dca
Document Type :
article
Full Text :
https://doi.org/10.1016/j.isci.2020.100937