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Background: A 66 years old presented with abnormal postmenopausal vaginal bleeding and was diagnosed with an endometrial lymphoma (diffuse large B cell type, DLBCL). A left breast lesion was found on PET CT which was subsequently biopsy-proven as a separate stage IE DLBCL, but she had no lymph node, bone marrow or spleen involvement. Aims: This study aimed to review the available literature and discuss the management and staging of synchronous extra-nodal DLBCL's. Results: Our patient was staged as having synchronous stage IE DLBCL's of the endometrium and breast. Subsequent molecular analysis (IgH gene rearrangement analysis) on both lesions, confirmed the two lesions to be clonally unrelated. Conclusions: Staging of synchronous extra-nodal lymphomas, particularly when they arise in rare sites such as the endometrium and breast, is difficult and previously unreported. We present our rationale for defining our patient's disease as synchronous stage IE DLBCL's. [ABSTRACT FROM AUTHOR]

The results described in this paper confirm that excision of the aganglionic segment is the rational treatment of Hirschsprung's disease. Although the operation may have formidable complications, it is justified; if left untreated the majority of these children die. It is emphasised that early diagnosis is possible, since twelve of the fourteen cases in this series were diagnosed in the first year and five were suspected in the first week. Abnormal bowel habit, in association with a history of delay in passing meconium, should suggest the possibility of Hirschsprung's disease. [ABSTRACT FROM AUTHOR]

The presence of Staph. pyogenes in the nasal and intestinal flora of children under prolonged Achromycin treatment has been investigated. The administration of Achromycin in a dosage of 250 mgm. daily has been found to select strongly for resistant strains; most of the Achromycin-resistant organisms selected were in addition resistant to penicillin or to penicillin and streptomycin. Achromycin treatment also appeared to increase the overall parasitism of the intestinal tract by Staph. pyogenes: no increase in nasal parasitism by Staph. pyogenes was observed. In general our results indicate the importance of the respiratory and intestinal tracts, and particularly the latter, as foci from which, in patients under antibiotic treatment, antibiotic-resistant strains of Staph. pyogenes may be disseminated. [ABSTRACT FROM AUTHOR]