1. Oxidative stress and anti-oxidant defense system in Iranian women with polycystic ovary syndrome.
- Author
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Moti, Mahtab, Amini, Leila, Mirhoseini Ardakani, Soheila Sadat, Kamalzadeh, Sara, Masoomikarimi, Masoomeh, and jafarisani, Moslem
- Subjects
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POLYCYSTIC ovary syndrome , *INFERTILITY , *C-reactive protein , *OXIDATIVE stress , *ANOVULATION , *HYPERANDROGENISM - Abstract
Background: Polycystic ovary syndrome (PCOS) is a common disorder of infertility which affects more than 100 million women. It is characterized by chronic anovulation, hyper androgenism and obesity. PCOS is also associated with oxidative stress changes. Objective: Here, we aimed to investigate the level of antioxidants and oxidative stress in Iranian women with PCOS as a predictive factor for cardiovascular disease for the first time in Iran. Materials and Methods: In this cross sectional study 30 women with PCOS and 30 healthy women were included. C-reactive protein, serum insulin, advanced oxidation protein products, and level of total antioxidants status were measured from blood samples. Results: The levels of serum insulin, C-reactive protein, advanced oxidation protein productswere significantly increased in women with PCOS compared with healthy women but there was a decrease in level of total antioxidants status in PCOS women. Conclusion: These changes show that oxidative stress contributes to PCOS and the decrease of antioxidants leads to increase of oxidation products contributing to PCOS. [ABSTRACT FROM AUTHOR]
- Published
- 2015