1. Wnt5a Suppresses β-catenin Signaling during Hair Follicle Regeneration
- Author
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Fang Deng, Yizhan Xing, Xiaogen Ma, Yuhong Li, Jin Yang, and Haiying Guo
- Subjects
0301 basic medicine ,Beta-catenin ,Wnt-5a Protein ,Cell Line ,Wnt signaling pathway ,regeneration ,03 medical and health sciences ,Wnt3A Protein ,medicine ,Humans ,Regeneration ,beta Catenin ,Cell Proliferation ,hair follicle ,integumentary system ,biology ,Cell growth ,Regeneration (biology) ,Gene Expression Regulation, Developmental ,General Medicine ,β-catenin ,Wnt5a ,Hair follicle ,Molecular biology ,body regions ,Reverse transcription polymerase chain reaction ,030104 developmental biology ,medicine.anatomical_structure ,embryonic structures ,biology.protein ,sense organs ,WNT3A ,Research Paper - Abstract
Hair follicles display periodic growth. Wnt signaling is a critical regulator for hair follicle regeneration. Previously, we reported that Wnt5a inhibits the telogen-to-anagen transition of hair follicles, but the mechanism by which this process occurs has not yet been reported. Here, we determined the expression patterns of Wnt signaling pathway molecules by quantitative reverse transcription polymerase chain reaction, western blot, and immunohistochemistry and found that β-catenin signaling was suppressed by Wnt5a. We then compared the phenotypes and expression patterns following β-catenin knockdown and Wnt5a overexpression during hair follicle regeneration induced by hair depilation and observed similar patterns. In addition, we performed a rescue experiment in the JB6 cell line and found that the inhibitory effect of Wnt5a on cell proliferation could be rescued by the addition of Wnt3a. Our data reveal that Wnt5a suppresses the activation of β-catenin signaling during hair follicle regeneration.
- Published
- 2016