1. Effect of prenatal and perinatal antibiotics on maternal health in Malawi, Tanzania, and Zambia
- Author
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Aboud, Said, Msamanga, Gernard, Read, Jennifer S., Wang, Lei, Mfalila, Chelu, Sharma, Usha, Martinson, Francis, Taha, Taha E., Goldenberg, Robert L., and Fawzi, Wafaie W.
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ANTIBIOTICS , *MATERNAL health services , *MATERNAL mortality , *HIV infections , *CLINICAL trials , *PREGNANT women , *INFECTION prevention , *HIV infection epidemiology , *COMPARATIVE studies , *INFECTION , *LABOR complications (Obstetrics) , *RESEARCH methodology , *MEDICAL cooperation , *PRENATAL care , *PUERPERAL disorders , *RESEARCH , *RESEARCH funding , *MOTHERS , *EVALUATION research , *RANDOMIZED controlled trials , *DISEASE incidence , *ANTIBIOTIC prophylaxis , *ODDS ratio , *PREVENTION , *SOCIAL history - Abstract
Objective: We assessed the effect of prenatal and peripartum antibiotics on maternal morbidity and mortality among HIV-infected and uninfected women.Methods: A multicenter trial was conducted at clinical sites in 4 Sub-Saharan African cities: Blantyre and Lilongwe, Malawi; Dar es Salaam, Tanzania; and Lusaka, Zambia. A total of 1558 HIV-infected and 271 uninfected pregnant women who were eligible to receive both the prenatal and peripartum antibiotic/placebo regimens were enrolled. Pregnant women were interviewed at 20-24 weeks of gestation and a physical examination was performed. Women were randomized to receive either antibiotics or placebo. At the 26-30 week visit, participants were given antibiotics or placebo to be taken every 4 hours beginning at the onset of labor and continuing after delivery 3 times a day until a 1-week course was completed. Logistic regression and Cox proportional hazards models were used.Results: There were no significant differences between the antibiotic and placebo groups for medical conditions, obstetric complications, physical examination findings, puerperal sepsis, and death in either the HIV-infected or the uninfected cohort.Conclusion: Administration of study antibiotics during pregnancy had no effect on maternal morbidity and mortality among HIV-infected and uninfected pregnant women. [ABSTRACT FROM AUTHOR]- Published
- 2009
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