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Effect of prenatal and perinatal antibiotics on maternal health in Malawi, Tanzania, and Zambia
- Source :
-
International Journal of Gynecology & Obstetrics . Dec2009, Vol. 107 Issue 3, p202-207. 6p. - Publication Year :
- 2009
-
Abstract
- <bold>Objective: </bold>We assessed the effect of prenatal and peripartum antibiotics on maternal morbidity and mortality among HIV-infected and uninfected women.<bold>Methods: </bold>A multicenter trial was conducted at clinical sites in 4 Sub-Saharan African cities: Blantyre and Lilongwe, Malawi; Dar es Salaam, Tanzania; and Lusaka, Zambia. A total of 1558 HIV-infected and 271 uninfected pregnant women who were eligible to receive both the prenatal and peripartum antibiotic/placebo regimens were enrolled. Pregnant women were interviewed at 20-24 weeks of gestation and a physical examination was performed. Women were randomized to receive either antibiotics or placebo. At the 26-30 week visit, participants were given antibiotics or placebo to be taken every 4 hours beginning at the onset of labor and continuing after delivery 3 times a day until a 1-week course was completed. Logistic regression and Cox proportional hazards models were used.<bold>Results: </bold>There were no significant differences between the antibiotic and placebo groups for medical conditions, obstetric complications, physical examination findings, puerperal sepsis, and death in either the HIV-infected or the uninfected cohort.<bold>Conclusion: </bold>Administration of study antibiotics during pregnancy had no effect on maternal morbidity and mortality among HIV-infected and uninfected pregnant women. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANTIBIOTICS
*MATERNAL health services
*MATERNAL mortality
*HIV infections
*CLINICAL trials
*PREGNANT women
*INFECTION prevention
*HIV infection epidemiology
*COMPARATIVE studies
*INFECTION
*LABOR complications (Obstetrics)
*RESEARCH methodology
*MEDICAL cooperation
*PRENATAL care
*PUERPERAL disorders
*RESEARCH
*RESEARCH funding
*MOTHERS
*EVALUATION research
*RANDOMIZED controlled trials
*DISEASE incidence
*ANTIBIOTIC prophylaxis
*ODDS ratio
*PREVENTION
*SOCIAL history
Subjects
Details
- Language :
- English
- ISSN :
- 00207292
- Volume :
- 107
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- International Journal of Gynecology & Obstetrics
- Publication Type :
- Academic Journal
- Accession number :
- 45219401
- Full Text :
- https://doi.org/10.1016/j.ijgo.2009.07.037