1. DNA damage repair and survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy
- Author
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Ronchetti, Livia, Melucci, Elisa, De Nicola, Francesca, Goeman, Frauke, Casini, Beatrice, Sperati, Francesca, Pallocca, Matteo, Terrenato, Irene, Pizzuti, Laura, Vici, Patrizia, Sergi, Domenico, Di Lauro, Luigi, Amoreo, Carla Azzurra, Gallo, Enzo, Diodoro, Maria Grazia, Pescarmona, Edoardo, Vitale, Ilio, Barba, Maddalena, Buglioni, Simonetta, Mottolese, Marcella, Fanciulli, Maurizio, De Maria Marchiano, Ruggero, and Maugeri-Saccà, Marcello
- Subjects
Male ,Cancer Research ,DNA Repair ,γ-H2AX ,Antineoplastic Agents ,Cell Cycle Proteins ,Ataxia Telangiectasia Mutated Proteins ,Disease-Free Survival ,Histones ,Settore MED/04 - PATOLOGIA GENERALE ,Stomach Neoplasms ,pATM ,Biomarkers, Tumor ,DNA damage repair ,Humans ,TP53 ,Aged ,Tumor ,Settore MED/06 - ONCOLOGIA MEDICA ,gastric cancer ,Stomach ,Middle Aged ,ARID1A ,DNA-Binding Proteins ,Oncology ,Gastric Mucosa ,Female ,Protein Kinases ,Biomarkers ,DNA Damage ,Signal Transduction - Abstract
The DNA damage response (DDR) network is exploited by cancer cells to withstand chemotherapy. Gastric cancer (GC) carries deregulation of the DDR and harbors genetic defects that fuel its activation. The ATM-Chk2 and ATR-Chk1-Wee1 axes are deputed to initiate DNA repair. Overactivation of these pathways in cancer cells may represent an adaptive response for compensating genetic defects deregulating G
- Published
- 2016