DNA damage repair and survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy

Authors :: Ronchetti, Livia
Melucci, Elisa
De Nicola, Francesca
Goeman, Frauke
Casini, Beatrice
Sperati, Francesca
Pallocca, Matteo
Terrenato, Irene
Pizzuti, Laura
Vici, Patrizia
Sergi, Domenico
Di Lauro, Luigi
Amoreo, Carla Azzurra
Gallo, Enzo
Diodoro, Maria Grazia
Pescarmona, Edoardo
Vitale, Ilio
Barba, Maddalena
Buglioni, Simonetta
Mottolese, Marcella
Fanciulli, Maurizio
De Maria Marchiano, Ruggero
Maugeri-Saccà, Marcello
Source :: International journal of cancer. 140(11)
Publication Year :: 2016
Abstract: The DNA damage response (DDR) network is exploited by cancer cells to withstand chemotherapy. Gastric cancer (GC) carries deregulation of the DDR and harbors genetic defects that fuel its activation. The ATM-Chk2 and ATR-Chk1-Wee1 axes are deputed to initiate DNA repair. Overactivation of these pathways in cancer cells may represent an adaptive response for compensating genetic defects deregulating G

Tools