1. The multikinase inhibitor EC-70124 synergistically increased the antitumor activity of doxorubicin in sarcomas
- Author
-
Carlos Alvarez-Fernandez, Paula Costales, Juan Tornin, Lucia Fernandez-Nevado, Francisco Morís, Laura Santos, Patricia Oro, Aida Rodríguez, Maria Ana Hermosilla, Veronica Rey, María Teresa Fernández-García, Jhudit Pérez-Escuredo, Sofía T. Menéndez, Alejandro Braña, Oscar Estupiñan, Aurora Astudillo, Eva Allonca, Rene Rodriguez, and Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
- Subjects
Cancer Research ,Cell cycle checkpoint ,Carbazoles ,Mice, SCID ,Enginyeria dels materials [Àrees temàtiques de la UPC] ,Tumors--Treatment ,03 medical and health sciences ,chemistry.chemical_compound ,Mice ,0302 clinical medicine ,In vivo ,Mice, Inbred NOD ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Tumor Cells, Cultured ,Animals ,Humans ,Doxorubicin ,Midostaurin ,Protein kinase B ,Protein Kinase Inhibitors ,PI3K/AKT/mTOR pathway ,Tumors -- Tractament ,Kinase ,Chemistry ,Cancer--Treatment ,TOR Serine-Threonine Kinases ,Drug Synergism ,Sarcoma ,Staurosporine ,Xenograft Model Antitumor Assays ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,ATP-Binding Cassette Transporters ,Female ,Càncer -- Tractament ,Proto-oncogene tyrosine-protein kinase Src ,medicine.drug ,Signal Transduction - Abstract
This work was supported by the Agencia Estatal de Investigación (AEI)[MICINN/Fondo Europeo de Desarrollo Regional (FEDER) (RTC2016-4603-1 to EntreChem SL and SAF-2016-75286-R toR.R.), ISC III/FEDER [Miguel Servet Program] (CPII16/00049 to R.R.), Sara Borrell Program (CD16/00103 toS-T.M.) and Consorcio CIBERONC (CB16/12/00390)] and the Plan de Ciencia Tecnología e Innovación del Principado de Asturias (GRUPIN14-003). We want to particularly acknowledge for its collaboration, the Principado de Asturias BioBank (PT17/0015/0023),financed jointly by Servicio de Salud del Principado de Asturias, Instituto de Salud Carlos III and Fundación Bancaria Cajastur and integrated in the Spanish National Biobanks Network., Estupiñan, O., Santos, L., Rodriguez, A., Fernandez-Nevado, L., Costales, P., Perez-Escuredo, J., Hermosilla, M.A., Oro, P., Rey, V., Tornin, J., Allonca, E., Fernandez-Garcia, M.T., Alvarez-Fernandez, C., Braña, A., Astudillo, A., Menendez, S.T., Moris, F., Rodriguez, R.
- Published
- 2018