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The multikinase inhibitor EC-70124 synergistically increased the antitumor activity of doxorubicin in sarcomas
- Source :
- Recercat. Dipósit de la Recerca de Catalunya, instname, UPCommons. Portal del coneixement obert de la UPC, Universitat Politècnica de Catalunya (UPC), Scopus, RUO. Repositorio Institucional de la Universidad de Oviedo
- Publication Year :
- 2018
-
Abstract
- This work was supported by the Agencia Estatal de Investigación (AEI)[MICINN/Fondo Europeo de Desarrollo Regional (FEDER) (RTC2016-4603-1 to EntreChem SL and SAF-2016-75286-R toR.R.), ISC III/FEDER [Miguel Servet Program] (CPII16/00049 to R.R.), Sara Borrell Program (CD16/00103 toS-T.M.) and Consorcio CIBERONC (CB16/12/00390)] and the Plan de Ciencia Tecnología e Innovación del Principado de Asturias (GRUPIN14-003). We want to particularly acknowledge for its collaboration, the Principado de Asturias BioBank (PT17/0015/0023),financed jointly by Servicio de Salud del Principado de Asturias, Instituto de Salud Carlos III and Fundación Bancaria Cajastur and integrated in the Spanish National Biobanks Network.<br />Estupiñan, O., Santos, L., Rodriguez, A., Fernandez-Nevado, L., Costales, P., Perez-Escuredo, J., Hermosilla, M.A., Oro, P., Rey, V., Tornin, J., Allonca, E., Fernandez-Garcia, M.T., Alvarez-Fernandez, C., Braña, A., Astudillo, A., Menendez, S.T., Moris, F., Rodriguez, R.
- Subjects :
- Cancer Research
Cell cycle checkpoint
Carbazoles
Mice, SCID
Enginyeria dels materials [Àrees temàtiques de la UPC]
Tumors--Treatment
03 medical and health sciences
chemistry.chemical_compound
Mice
0302 clinical medicine
In vivo
Mice, Inbred NOD
Antineoplastic Combined Chemotherapy Protocols
medicine
Tumor Cells, Cultured
Animals
Humans
Doxorubicin
Midostaurin
Protein kinase B
Protein Kinase Inhibitors
PI3K/AKT/mTOR pathway
Tumors -- Tractament
Kinase
Chemistry
Cancer--Treatment
TOR Serine-Threonine Kinases
Drug Synergism
Sarcoma
Staurosporine
Xenograft Model Antitumor Assays
Oncology
030220 oncology & carcinogenesis
Cancer research
ATP-Binding Cassette Transporters
Female
Càncer -- Tractament
Proto-oncogene tyrosine-protein kinase Src
medicine.drug
Signal Transduction
Subjects
Details
- ISSN :
- 10970215
- Volume :
- 145
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- International journal of cancer
- Accession number :
- edsair.doi.dedup.....459e877b0384337f68ba47f23f7d302f