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Your search keyword '"Hisashi Sasaki"' showing total 4 results
Start Over Author "Hisashi Sasaki" Journal internal medicine
4 results on '"Hisashi Sasaki"'

1. Successful Control of Dasatinib-related Chylothorax by the Japanese Herbal Medicine 'Goreisan'

Author

Akihiko Kawana, Yohei Maki, Nobuyoshi Hayashi, Jun Miyata, Yuji Fujikura, Yoichi Tagami, Takayuki Yamamoto, Tomoya Sano, Chie Watanabe, Shinichiro Ota, Yosuke Okada, Hisashi Sasaki, Hiraku Ogata, and Yoshifumi Kimizuka

Subjects
Adult, Male, medicine.medical_specialty, Water flow, Dasatinib, Antineoplastic Agents, Case Report, 030204 cardiovascular system & hematology, Chylothorax, 03 medical and health sciences, 0302 clinical medicine, Refractory, chronic myeloid leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Internal Medicine, Humans, Medicine, Effective treatment, Goreisan, Intensive care medicine, Adverse effect, Aged, Aged, 80 and over, Plant Extracts, business.industry, Myeloid leukemia, General Medicine, Middle Aged, medicine.disease, Pleural Effusion, aquaporin, Female, Radiography, Thoracic, 030211 gastroenterology & hepatology, Medicine, Kampo, business, Phytotherapy, medicine.drug
Abstract

Dasatinib-related chylothorax is a rare adverse event, and the mechanism underlying its occurrence is still not fully understood. We herein report the case of a 73-year-old woman with chronic myeloid leukemia (CML) who developed dasatinib-related chylothorax refractory to conventional treatments, except for steroids. To the best of our knowledge, this is the first case of dasatinib-related chylothorax which was successfully controlled by combining diuretics with the Japanese herbal medicine “Goreisan.” “Goreisan” is known to inhibit aquaporin channels and regulate the water flow. Our findings showed that “Goreisan” is an effective treatment option for uncontrollable dasatinib-related chylothorax.

Published
2019

2. Development of Allergic Bronchopulmonary Aspergillosis in a Patient with Crohn's Disease

Author

Akihiko Kawana, Nobuyoshi Hayashi, Yohei Maki, Hisashi Sasaki, Yoshifumi Kimizuka, Jun Miyata, and Yuji Fujikura

Subjects
Male, Case Report, 030204 cardiovascular system & hematology, Inflammatory bowel disease, 03 medical and health sciences, 0302 clinical medicine, Crohn Disease, inflammatory bowel disease, Eosinophilic, Internal Medicine, medicine, Humans, pulmonary disorder, Lung, Antibodies, Fungal, Asthma, Aged, Crohn's disease, Bronchiectasis, biology, anti-tumor necrosis factor-α antibody, business.industry, aspergillus, Aspergillosis, Allergic Bronchopulmonary, General Medicine, asthma, Immunoglobulin E, medicine.disease, Eosinophils, Immunology, biology.protein, 030211 gastroenterology & hepatology, Radiography, Thoracic, Antibody, Allergic bronchopulmonary aspergillosis, Complication, business, Tomography, X-Ray Computed
Abstract

Allergic bronchopulmonary aspergillosis (ABPA) is an eosinophilic inflammatory condition characterized by exaggerated immune responses to the fungal genus Aspergillus. Pulmonary manifestations in patients with Crohn's disease (CD) are frequent comorbidities. A 66-year-old man with CD treated with an anti-tumor necrosis factor-α antibody presented with dyspnea. Laboratory findings of elevated blood eosinophils and total serum IgE and positive aspergillus-specific antibodies as well as imaging findings of central bronchiectasis and mucoid impaction indicated a diagnosis of ABPA. To our knowledge, this is the first report of ABPA arising in a patient with CD. We discuss the pathophysiological mechanism of this rare complication.

Published
2019

3. Empyema with Multiple Bronchopleural Fistulae Improved by Bronchial Occlusion Using an Endobronchial Watanabe Spigot with the Push and Slide Method

Author

Yohei Maki, Yoichi Tagami, Akihiko Kawana, Yusuke Hamakawa, Hisashi Sasaki, Yuji Fujikura, Kazuhisa Misawa, and Nobuyoshi Hayashi

Subjects
Male, medicine.medical_specialty, Case Report, bronchopleural fistula (BPF), 030204 cardiovascular system & hematology, endobronchial Watanabe spigot (EWS), 03 medical and health sciences, 0302 clinical medicine, Bronchoscopy, Occlusion, Internal Medicine, medicine, Humans, Empyema, Pleural, push and slide method, Bronchus, business.industry, Treatment options, General Medicine, Bronchial occlusion, Middle Aged, Pleural Diseases, respiratory system, medicine.disease, Empyema, respiratory tract diseases, Surgery, Pleural Effusion, Treatment Outcome, medicine.anatomical_structure, Balloon occlusion, empyema, 030211 gastroenterology & hepatology, Bronchial Fistula, Respiratory Tract Fistula, Therapeutic Occlusion, business
Abstract

The push and slide method is a method of endoscopic bronchial occlusion using an endobronchial Watanabe spigot that facilitates occlusion of the target bronchus rapidly and accurately using a guidewire. We herein report the case of a man who was diagnosed with empyema forming bronchopulmonary fistulae that was successfully treated by endoscopic bronchial occlusion. Because of the multiple fistulae, balloon occlusion was not a favorable therapeutic approach. Instead, the push and slide method was used in order to detect the fistulae. Endoscopic occlusion, particularly that using the push and slide method, may be a valid treatment option for empyema with multiple bronchopulmonary fistulae.

Published
2019

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