1. Magnetic biosensors for genetic screening of cystic fibrosis.
- Author
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Lagae, L., Wirix-Speetjens, R., Liu, C. -X., Laureyn, W., Borghs, G., Harvey, S., Galvin, P., Ferreira, H. A., Graham, D. L., Freitas, P. P., Clarke, L. A., and Amaral, M. D.
- Subjects
CYSTIC fibrosis ,BIOSENSORS ,MAGNETORESISTANCE ,NUCLEOTIDE sequence ,GENETIC disorders ,DETECTORS - Abstract
The article focuses on the use of magnetic bio-sensors for the genetic screening of cystic fibrosis. Different groups have worked on demonstrating the proposed magnetic biosensor concepts as a gene sensor, in which specific deoxyribonucleic acid (DNA) sequences are detected by the magneto-resistive sensors. Most groups pursued the static approach or post-hybridization detection approach, where known DNA sequences (probes) are first patterned onto the array of magnetic sensors. An aliquot of unknown DNA, called target or analyte, labeled with a bio-molecule called biotin is passed over the array, enabling hybridization if probe and target DNA sequences are complementary.
- Published
- 2005
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